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Microbiome & Chronic Diseases

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Enterobacteriaceae {10000123}

Record Keys


Organism:
Enterobacteriaceae
Class:[  ]

Details


Initialisation date:
2020-09-06

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Meta Information


Taxonomy:
Family
Domain:
Bacteria
Zone:[  ]
Enzyme:[  ]
Function:[  ]

Notes


[  ]

Shared Notes


  • [1.63
    - Members of the Enterobacteriaceae family have a proinflammatory lipopolysaccharide (LPS) in the outer membrane and can exacerbate inflammation. A high relative abundance of Enterobacteriaceae is reported in inflammatory bowel diseases, in metabolic disorders like type 2 diabetes, and in immune diseases like cancers.
  • [1.64
    - Stress-exposed mice > develop ileal dysbiosis, dominated by the expansion of Enterobacteriaceae.
    - Stress-induced glucocorticoids promote > apoptosis of CD45+CD90+ cells that normally produce IL-22, a cytokine that is essential for the maintenance of ileal mucosal barrier integrity.
    - Blockade of glucocorticoid signaling or administration of recombinant IL-22 > restores mucosal immunity, prevents ileal dysbiosis.

Common References