Enhancing CD4(+) T regulatory
- Mice colonized with Clostridia bacteria had more regulatory T cells, a type of cell that dampens immune responses. The Clostridia mice also produced more of a molecule called IL-22 that strengthens the intestinal lining. (1)
- Clostridiales species are significantly reduced in CRC patients compared with healthy controls.
- Oral application of a mix of four Clostridiales strains (CC4) in mice prevented and even successfully treated CRC as stand-alone therapy. This effect depended on intratumoral infiltration and activation of CD8+ T cells.
- Single application of Roseburia intestinalis or Anaerostipes caccae is even more effective than CC4.
- The CC4 mix supplementation outperformed anti-PD-1 therapy in mouse models of CRC and melanoma.