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Microbiome & Chronic Diseases

Evidence Based Medicine
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Clostridiales {10000119}

Record Keys


Organism:
Clostridiales
Class:[  ]

Details


Initialisation date:
2020-09-06

Links


Meta Information


Taxonomy:
Order
Domain:
Bacteria
Zone:
Gut Lumen
Enzyme:[  ]
Function:
Enhancing CD4(+) T regulatory

Notes


- Mice colonized with Clostridia bacteria had more regulatory T cells, a type of cell that dampens immune responses. The Clostridia mice also produced more of a molecule called IL-22 that strengthens the intestinal lining. (1)

Shared Notes


  • [1.3
    - Clostridiales species are significantly reduced in CRC patients compared with healthy controls.
    - Oral application of a mix of four Clostridiales strains (CC4) in mice prevented and even successfully treated CRC as stand-alone therapy. This effect depended on intratumoral infiltration and activation of CD8+ T cells.
    - Single application of Roseburia intestinalis or Anaerostipes caccae is even more effective than CC4.
    - The CC4 mix supplementation outperformed anti-PD-1 therapy in mouse models of CRC and melanoma.

Common References