Microbiome & Chronic Diseases

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Lactobacillus {10000118}

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Gut Lumen
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- Lactubacillus are reduced in chronic stress conditions, Can Lactobacillus probiotics relieve chronic stress?

Shared Notes

  • [1.136
    - Two species from Lactobacillus genus ( Lactobacillus johnsonii, Lactobacillus gasseri) act upon mitochondria in the liver leading to the improvement of lipid metabolism.
    - Metabolomics analyses revealed that reduced glutathione may mediate these effects.
    - The mice receiving those Lactobacilli also had a lower fat mass index than those fed only a western diet
  • [1.137
    - The glutamate decarboxylase gen in some LAB strains is a potential GABA producer.
    - There are varying levels of inhibition against fungi, with Lactiplantibacillus plantarum and Lentilactobacillusparabuchneri exhibiting the highest suppression against the some strains of Fusarium, Aspergillus, and Penicillium.
    - The antifungal activity is mainly due to the activity of acids produced by LAB.
    - The antibacillus activity reveals a high inhibition potential of the majority of LAB isolated from sourdough against some strains of Bacillus.
  • [1.138
    - Lactobacillus can resist the antimicrobial activity of bile salts.
  • [1.139
    - Smectite clay promotes lactic acid bacteria (LABs) to form biofilms on its surface
    - Smectite with LABs inhibits tumor growth in mice
    - Smectite with LABs enhances anti-cancer chemo/immunotherapy in mice
    - Smectite with LABs activates dendritic cells via TLR2 signaling
  • [1.140
    - Following an extremely stressful period, fewer species of Lactobacillus are present in the stool.
  • - The administration of a probiotic cocktail, composed of Lactobacillus rhamnosus and Lactobacillus helveticus, reduced the symptoms of depression and anxiety
  • - Lactobacillus can produce GABA
  • - Lactobacillus can produce acetylcholine
  • [1.141
    - Lactobacillus given to letrozole-treated (induces PCOS) rats reduced androgen levels, improved estrous cyclicity, normalized ovarian morphology, as well as increased Lactobacillus and Clostridium species and decreased Prevotella.
  • [1.142
    - A diet rich in salt (i.e. high salt diet, or HSD) for instance, can result in depletion of the gut bacteria Lactobacillus spp., which results in T helper cell-mediated immune dysregulation and cognitive dysfunction.
    - A diet rich do not increase the serum concentration of proinflammatory molecules.
    - Adult male offspring from HSD-fed mice show hyperactivity, reduced sociability and increased repetitive behaviors
  • [1.143
    - The excellent biological activities of these functional foods, such as anti-inflammatory and immunomodulatory functions, are widely attributable to their high antioxidant content and lactic acid-producing bacteria
  • [1.135
    - Gamma aminobutyrate (GABA), a major CNS inhibitory neurotransmitter, is produced from Lactobacillus and is the first bacterium that is colonized with most vaginally born infants.
  • - Acetylcholine is produced from Lactobacillus
  • [1.144
    - Lactobacillus > positively correlated with fasting glucose and HbA1c levels > increased insulin resistance.

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