- Clostridia bacteria gene clusters are able to produce fatty acid amides (FAAs), which are signaling molecules produced by humans.
- FAAs are known to have diverse physiological effects — ranging from immunoregulation to sensing pain to wound healing.
- Bacterial enzymes from Clostridia bacteria used diet-derived substrates to produce FAAs that interact with human receptors.
- Genera within the Clostridia and Bacilli classes are necessary and sufficient for P-gp induction in the intestinal epithelium in mouse models.
- [1.1] Gut-inhabiting Clostridia build human GPCR ligands by conjugating neurotransmitters with diet- and human-derived fatty acids  [Research] [Nature Microbiology] [Journal] 
- [1.2] Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis  [Research] [Microbiome] [Journal]