MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Prevotella {10000253}

Record Keys


Organism:
Prevotella
Class:[  ]

Details


Initialisation date:
2020-09-29

Meta Information


Taxonomy:
Genus
Domain:
Bacteria
Zone:[  ]
Enzyme:[  ]
Function:
Mucin-degrading

Notes


- Prevotella contains enzymes that are important in mucin degradation, which may disrupt the colonic mucus barrier and increase intestinal permeability

Shared Notes


  • [1.180
    - There is a correlation between higher gut microbiota diversity and higher vegetable intake, but only in participants who harbored an overrepresentation of Prevotella in their gut microbiota
  • [1.181
    - Recent exposure to antibiotics is the best predictor of decreased Prevotella.
  • - There is a clear association between decreased normalised abundance of Prevotella in faecal samples collected at 12 months of age and increased behavioural problems at 2 years.
  • [1.182
    - Carbohydrate (fiber) consumption > increased Prevotella
  • - Prevotella are more common in non-Westernized populations consuming a plant-rich diet or in Western populations with high adherence to a Mediterranean or vegetarian diet
  • [1.183
    - Prevotella grows best on carbohydrates.
  • [1.184
    - Prevotella in saliva is at higher relative abundance compared to healthy controls.
  • [1.42
    - 9,10-dichloro-octadecanoic acid (stearic acid) > positive association > microflora including Klebsiella, Prevotella, and Enterbacter > all overrepresented in HTN.
    - In HTN > microbial richness and diversity > decreased with Prevotella-dominated gut enterotype.
    - Faecalibacterium, Oscillibacter, Roseburia, Bifidobacterium, Coprococcus, and Butyrivibrio > declined in pHTN and HTN patients.
    - The enterotype dominated by Prevotella > increased in pHTN and HTN populations.
    - Stearic acid, an important metabolite in HTN, is positively linked to Prevotella.
    - Prevotella > triggering the inflammatory response > HTN.
  • [1.185
    - Decreased Prevotella > faster PD progression

Common References