Microbiome & Chronic Diseases

Evidence Based Medicine

Escherichia coli ⇒ Escherichia {10000115}

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Escherichia coli


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- AICE (type of E. Coli ) may deteriorate or cause Gut lumen inflammation (Crohn's disease) by using fucose and converting it to propionate.

Shared Notes

  • [1.13
    - AIEC bacteria uses 1,2-propanediol, a byproduct of the breakdown of fucose that is found in the lining of the intestines.
    - AIEC bacteria converts 1,2-propanediol to propionate.
  • [1.43
    - Emulsifiers, widely used in processed food to improve food appearance, texture, and palatability due to their intrinsic properties. Emulsifiers affect the gut microbiota, disrupt the mucosal barrier, and promote inflammation; in mice models, they induce metabolic syndrome, colitis, and translocation of Escherichia coli.
  • [1.44
    - Bacterial chaperone protein Escherichia coli caseinolytic protease B (ClpB) and food-derived antigens were recently described to trigger the production of autoantibodies cross-reacting with appetite-regulating hormones and neurotransmitters.
  • [1.45
    - A high-fat diet impairs mitochondrial uptake of oxygen into host enterocytes and elevates nitrate in the mucus, which in turn weakens healthy anaerobic gut function. Facultative anaerobes such as the pathobiont Escherichia coli become dominant, which leads to an overall increase in the amount of choline catabolized into the precursor for TMAO.
  • [1.42
    - 38 E. coli genes promote neurodegeneration.
    - Two of these genes, csgA and csgB, code for proteins that form curli, one type of bacterial amyloid fibers.
    - Curli cross-seeds and colocalizes with α-syn both in C. elegans neurons and human neuroblastoma cells.
    - Curli-induced α-syn aggregations down-regulate mitochondrial genes, causing energy failure in neurons.
    - Curli may have general effects in promoting neuropathologies induced by different aggregation-prone proteins, such as A-β in Alzheimer’s disease, Huntingtin in Huntington’s disease, and SOD1 in amyotrophic lateral sclerosis.
  • [1.46
    - Flagellins of the probiotic E. coli Nissle 1917 induce beta-defensin via Toll-like receptor 5.
  • [1.47
    - Adherent-invasive E. coli (AIEC), > prevalent in up to half the individuals with Crohn’s Disease (CD)
    - Among the genes related to AIEC pathogenicity, fim has the potential to generate an inflammatory reaction from the intestinal epithelial cells and macrophages, as it interacts with TLR4, inducing the production of inflammatory cytokines independently of LPS.

Common References