MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Citrobacter rodentium ⇒ Citrobacter {10000222}

Record Keys


Organism:
Citrobacter rodentium
Class:

Details


Initialisation date:
2019-08-10

Links


Meta Information


Taxonomy:
Species
Domain:
Bacteria
Zone:[  ]
Enzyme:[  ]
Function:[  ]

Notes


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Shared Notes


  • [1.3
    - Switching mice from a standard grain-based rodent chow to a high-fat, low-fiber Western-style diet resulted in a rapid reduction in the number of gut bacteria.
    - Mice fed the Western-style diet were frequently unable to clear the pathogen Citrobacter rodentium from the colon. They were also prone to developing chronic infection when re-challenged by this pathogen.
  • [1.2
    - Pectins > anti-inflammatory properties on intestinal immunity > direct interactions on Toll-like receptors (TLRs) in the small intestine or via stimulating microbiota-dependent effects in the large intestine.
    - Pectins> prevent C. rodentium induced colonic inflammation > lowering the C. rodentium load in the caecum independently of the DB.

Common References