Microbiome & Chronic Diseases

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Bilophila wadsworthia ⇒ Bilophila {10001322}

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Bilophila wadsworthia


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Shared Notes

  • [1.5
    -Bilophila wadsworthia ultimately produces hydrogen sulfide from DHPS via a metabolic pathway that was also only recently discovered,
  • [1.6
    - Diet rich in high saturated fats promotes chronic inflammation.
    - One explanation is that the amino acid taurine, present in saturated fats, linked to bile acids, seems to increase substrate availability for sulfur-reducing bacteria like Bilophila Wadsworthia, highly prevalent in the dysbiotic microbiota of IBD patients.
  • [1.7
    - Carbohydrate-restricted (ketogenic) diet potentiates CI induced by intermittent hypoxia in mice and alters the gut microbiota.
    - Depleting the microbiome reduces CI, whereas transplantation of the risk-associated microbiome or monocolonization with Bilophila wadsworthia confers CI in mice fed a standard diet.
    - B. wadsworthia and the risk-associated microbiome disrupt hippocampal synaptic plasticity, neurogenesis, and gene expression.
    - The CI is associated with microbiome-dependent increases in intestinal interferon-gamma (IFNg)-producing Th1 cells. - Inhibiting Th1 cell development abrogates the adverse effects of both B. wadsworthia and environmental risk factors on CI.
  • [1.8
    - B. Wadsworthia > large quantities in PD patients > increased sulfite production in the intestine.
    - Sulfite > neurotoxin > mediates the mitochondrial energy balance of the brain