sIgA {90000608} Record Keys Parent:[ ] Definition:sIgA Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Veillonella parvula] [#Human breast milk, #Infants] - sIgA content in human milk at 42 days was positively correlated with V. parvula. - sIgA > regulate microbial colonization and the infant immune response [1.2] [#Natural oral microbiomes] [#Streptococcus mutans] - sIgA binds to oral bacteria, such as #Streptococcus mitis, #Streptococcus oralis, and S. mutans, which have epitopes recognized by sIgA, selectively recruiting these specific bacteria to the mucus layer on the mucosal surfaces of the oral cavity. [1.3] [#Tryptophan, #β-defensins] - Trp is responsible for the expression of secretory immunoglobulin A (sIgA) and β-defensins [1.4] [#Low fibre Diet] - IgAs are among the most abundant proteins in mucus. - Their secretion is a key anti-microbial mechanism, and IgA coating has been proposed to identify bacteria that are potentially more colitogenic. - fiber deprivation initiates early disruptions in IgA-microbiota interactions along with a loss of IgA-producing plasma cells.References Notes[ ]
