DHPPA {90000302} Record Keys Parent:[ ] Definition:DHPPA Queue:[ ] Details Initialisation date:[ ] Specification: 3-(3,4-dihydroxyphenyl) propionic acidSource: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Parkinson’s Disease] - Tyrosine decarboxylase (TyrDC), present in gut microbes, converts #L-Dopa into #Dopamine, which does not cross the blood-brain barrier and accumulates in the gut, causing many side effects such as cardiac arrhythmias and nausea. - levodopa can be metabolized by Clostridium sporogenes to 3-(3,4-dihydroxyphenyl) propionic acid (DHPPA), a metabolite that inhibits muscle contraction in the ileum, reduces intestinal movement, and impairs absorption in the small intestine.References Notes[ ]
