MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine
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Major depressive disorder ⇒ Depression {40000197}

Record Keys


Definition:
Major depressive disorder
Class:

Details


Other Terms:
MDD
Initialisation date:
2020-12-03

Meta Information


ICD:[  ]
Category:
Psychiatry
MedDra ID:
10012378
MedDra Level:
pt

Notes


[  ]

Shared Notes


  • [1.4
    -The levels of fecal GABA and its relevant metabolites (N-acetylornithine, proline, oxoproline, and glutathione) were consistently decreased in MDD relative to HCs, suggesting a decrease in GABA content in the intestine.
    - A microbial enzyme–related gene (BetB) that participated in arginine metabolism to GABA was down-regulated in MDD.
    - Three microbial genes involved in the metabolism of glutamine to GABA was up-regulated in MDD.
    - Fecal GABA level in the patients with MDD may be modulated by a panel of gut microbes, which may be implicated in the development of MDD.
    - Majority of genes involved in the phenylalanine catabolic pathways were decreased in MDD, suggesting an inhibition of fecal phenylalanine degradation.
    - A downstream catabolic product of homovanillate was also decreased in MDD. These findings were consistent with disturbances of phenylalanine metabolism in MDD.
    - A gene (kynu) involved in kynurenic acid to quinolinic acid was enriched in MDD subjects relative to HCs, yielding an increased synthesis of the neurotoxic metabolite quinolinic acid.
    - A lower fecal quinolinic acid level in MDD.
    - These preliminary findings may account for the higher blood level of quinolinic acid observed in MDD.
    - Microbial GABA, phenylalanine, and quinolinic acid metabolisms were linked with MDD onset
  • [1.8
    - Major depression and anxiety states, are common in patients presenting with irritable bowel syndrome (IBS)
  • [1.9
    - Patients with major depressive disorder showed a statistically significant overrepresentation of Bacteroides enterotype 2 compared to controls.
  • [1.10
    - γ-aminobutyric acid (GABA) production by human-derived Bacteroides is widespread, and there is a correlation between brain signatures of depression and fecal Bacteroides levels in patients with major depressive disorder.
  • [1.11
    - MDD is associated with higher relative abundance of Clostridiales , OTU16802 Bacteroides and Prevotellaceae.
    - Similar association directions of for Blautia with MDD and SCZ.
    - Increased Bacilli is potentially associated with a higher risk of MDD, possibly involving dopamine metabolism which might play a role in the major symptoms of MDD.
    - Animal models found increased levels of Gammaproteobacteria were also associated with higher MDD risk and fluoxetine treatment was effective, implying strong correlations between gut microbiota and anxiety- and depression-like behaviors. (6)


[Coverage other Diseases (Overlap > 0.25)]

DiseaseOverlapCommon increased OrganismCommon decreased Organism
Major depressive disorder 1.0000 21 (100%) : Actinomyces | Alistipes | Anaerostipes | Bacteroidaceae | Bacteroidales | Bacteroides | Bacteroidetes | Bifidobacteriaceae | Blautia | Clostridium cluster XVIII | Eggerthella | Eubacterium | Lachnospiraceae incertae sedis | Megamonas | Oscillibacter | Parabacteroides | Parasutterella | Phascolarctobacterium | Roseburia | Streptococcus | Veillonella 19 (100%) : Anaerovorax | Bacteroides | Bifidobacterium | Blautia | Clostridium | Clostridium cluster XVIII | Clostridium group XI | Coprococcus | Dialister | Enterobacteriaceae | Eubacterium | Faecalibacterium | Lachnospiraceae | Lactobacillus | Oscillibacter | Phascolarctobacterium | Prevotella | Ruminococcus | Sutterella
Colorectal cancer 0.5614 7 (33%) : Actinomyces | Bacteroides | Eubacterium | Oscillibacter | Phascolarctobacterium | Roseburia | Streptococcus 15 (79%) : Bacteroides | Bifidobacterium | Blautia | Coprococcus | Dialister | Enterobacteriaceae | Eubacterium | Faecalibacterium | Lachnospiraceae | Lactobacillus | Oscillibacter | Phascolarctobacterium | Prevotella | Ruminococcus | Sutterella
Obesity 0.5589 8 (38%) : Alistipes | Bacteroides | Blautia | Megamonas | Parabacteroides | Parasutterella | Phascolarctobacterium | Roseburia 14 (74%) : Anaerovorax | Bacteroides | Bifidobacterium | Blautia | Coprococcus | Dialister | Eubacterium | Faecalibacterium | Lachnospiraceae | Lactobacillus | Oscillibacter | Phascolarctobacterium | Prevotella | Ruminococcus
Crohn's disease 0.5113 6 (29%) : Actinomyces | Anaerostipes | Blautia | Eggerthella | Streptococcus | Veillonella 14 (74%) : Bacteroides | Bifidobacterium | Blautia | Clostridium | Coprococcus | Dialister | Eubacterium | Faecalibacterium | Lachnospiraceae | Lactobacillus | Oscillibacter | Phascolarctobacterium | Prevotella | Ruminococcus
Ulcerative Colitis 0.5013 10 (48%) : Actinomyces | Anaerostipes | Bacteroides | Bacteroidetes | Bifidobacteriaceae | Blautia | Eggerthella | Roseburia | Streptococcus | Veillonella 10 (53%) : Bacteroides | Bifidobacterium | Blautia | Coprococcus | Dialister | Eubacterium | Lachnospiraceae | Lactobacillus | Phascolarctobacterium | Prevotella
Parkinson's Disease 0.4962 12 (57%) : Alistipes | Bacteroides | Bifidobacteriaceae | Blautia | Clostridium cluster XVIII | Lachnospiraceae incertae sedis | Parabacteroides | Parasutterella | Phascolarctobacterium | Roseburia | Streptococcus | Veillonella 8 (42%) : Blautia | Clostridium | Coprococcus | Faecalibacterium | Lachnospiraceae | Lactobacillus | Prevotella | Ruminococcus
Irritable bowel syndrome 0.4298 7 (33%) : Actinomyces | Alistipes | Bacteroides | Blautia | Roseburia | Streptococcus | Veillonella 10 (53%) : Anaerovorax | Bacteroides | Bifidobacterium | Blautia | Coprococcus | Eubacterium | Faecalibacterium | Lachnospiraceae | Lactobacillus | Oscillibacter
Type 2 diabetes 0.4248 9 (43%) : Actinomyces | Alistipes | Bacteroides | Bifidobacteriaceae | Eggerthella | Eubacterium | Parabacteroides | Roseburia | Streptococcus 8 (42%) : Bifidobacterium | Coprococcus | Eubacterium | Faecalibacterium | Lachnospiraceae | Phascolarctobacterium | Prevotella | Sutterella
Non-alcoholic fatty liver disease 0.3822 5 (24%) : Bacteroides | Oscillibacter | Roseburia | Streptococcus | Veillonella 10 (53%) : Bacteroides | Blautia | Clostridium | Coprococcus | Enterobacteriaceae | Faecalibacterium | Lactobacillus | Oscillibacter | Prevotella | Ruminococcus
Infantile eczema 0.3772 7 (33%) : Anaerostipes | Bacteroidaceae | Lachnospiraceae incertae sedis | Parabacteroides | Phascolarctobacterium | Roseburia | Veillonella 8 (42%) : Bifidobacterium | Clostridium group XI | Dialister | Lactobacillus | Oscillibacter | Prevotella | Ruminococcus | Sutterella
Alcoholism 0.3747 8 (38%) : Actinomyces | Bacteroides | Eubacterium | Megamonas | Parabacteroides | Phascolarctobacterium | Streptococcus | Veillonella 7 (37%) : Bifidobacterium | Blautia | Coprococcus | Faecalibacterium | Lachnospiraceae | Prevotella | Ruminococcus
Asthma 0.3697 10 (48%) : Actinomyces | Alistipes | Anaerostipes | Bacteroides | Eubacterium | Oscillibacter | Parabacteroides | Roseburia | Streptococcus | Veillonella 5 (26%) : Anaerovorax | Bifidobacterium | Dialister | Faecalibacterium | Prevotella
Hepatocellular cancer 0.3672 11 (52%) : Actinomyces | Alistipes | Anaerostipes | Bacteroides | Eggerthella | Eubacterium | Oscillibacter | Parabacteroides | Phascolarctobacterium | Streptococcus | Veillonella 4 (21%) : Bifidobacterium | Dialister | Lactobacillus | Phascolarctobacterium
HIV infection 0.3609 3 (14%) : Oscillibacter | Streptococcus | Veillonella 11 (58%) : Bacteroides | Bifidobacterium | Blautia | Clostridium | Coprococcus | Dialister | Eubacterium | Faecalibacterium | Lachnospiraceae | Prevotella | Ruminococcus
Autism 0.3559 5 (24%) : Bacteroides | Megamonas | Parabacteroides | Roseburia | Streptococcus 9 (47%) : Bacteroides | Bifidobacterium | Blautia | Coprococcus | Dialister | Lachnospiraceae | Lactobacillus | Phascolarctobacterium | Prevotella
Alzheimer's disease 0.3534 6 (29%) : Alistipes | Bacteroides | Bacteroidetes | Blautia | Phascolarctobacterium | Streptococcus 8 (42%) : Bacteroides | Bifidobacterium | Blautia | Clostridium | Dialister | Lachnospiraceae | Ruminococcus | Sutterella
Multiple Sclerosis 0.3509 7 (33%) : Actinomyces | Alistipes | Bacteroides | Blautia | Eggerthella | Parabacteroides | Streptococcus 7 (37%) : Bacteroides | Blautia | Clostridium | Dialister | Faecalibacterium | Lachnospiraceae | Prevotella
Chronic kidney disease 0.3296 5 (24%) : Actinomyces | Bacteroides | Eggerthella | Parabacteroides | Streptococcus 8 (42%) : Bacteroides | Bifidobacterium | Clostridium | Coprococcus | Dialister | Faecalibacterium | Prevotella | Ruminococcus
Schizophrenia 0.3246 7 (33%) : Actinomyces | Bacteroidaceae | Blautia | Eggerthella | Oscillibacter | Parasutterella | Veillonella 6 (32%) : Clostridium | Coprococcus | Enterobacteriaceae | Faecalibacterium | Lachnospiraceae | Sutterella
Cirrhosis 0.3246 7 (33%) : Bacteroidaceae | Bacteroides | Eubacterium | Parabacteroides | Phascolarctobacterium | Streptococcus | Veillonella 6 (32%) : Bacteroides | Bifidobacterium | Blautia | Lachnospiraceae | Prevotella | Ruminococcus
Hepatitis B 0.2982 7 (33%) : Actinomyces | Alistipes | Bacteroides | Eubacterium | Megamonas | Streptococcus | Veillonella 5 (26%) : Bacteroides | Bifidobacterium | Phascolarctobacterium | Prevotella | Ruminococcus
Cystic fibrosis 0.2794 4 (19%) : Bacteroides | Blautia | Streptococcus | Veillonella 7 (37%) : Bacteroides | Bifidobacterium | Blautia | Dialister | Faecalibacterium | Lachnospiraceae | Prevotella
Type 1 diabetes 0.2769 5 (24%) : Alistipes | Bacteroides | Blautia | Streptococcus | Veillonella 6 (32%) : Bifidobacterium | Dialister | Faecalibacterium | Lachnospiraceae | Lactobacillus | Prevotella
Psoriasis 0.2769 5 (24%) : Actinomyces | Bacteroides | Blautia | Parabacteroides | Streptococcus 6 (32%) : Bacteroides | Coprococcus | Faecalibacterium | Lachnospiraceae | Lactobacillus | Sutterella
Hypertension 0.2769 5 (24%) : Actinomyces | Eggerthella | Parabacteroides | Parasutterella | Streptococcus 6 (32%) : Bifidobacterium | Blautia | Clostridium | Coprococcus | Faecalibacterium | Oscillibacter
Ankylosing spondylitis 0.2694 8 (38%) : Actinomyces | Bacteroidaceae | Blautia | Eggerthella | Megamonas | Oscillibacter | Parasutterella | Streptococcus 3 (16%) : Clostridium | Eubacterium | Ruminococcus
Sjögren syndrome 0.2556 3 (14%) : Blautia | Streptococcus | Veillonella 7 (37%) : Bacteroides | Bifidobacterium | Blautia | Clostridium | Faecalibacterium | Prevotella | Ruminococcus
Clostridium difficile infection 0.2556 3 (14%) : Eggerthella | Parabacteroides | Veillonella 7 (37%) : Bacteroides | Bifidobacterium | Coprococcus | Dialister | Faecalibacterium | Phascolarctobacterium | Prevotella
Primary sclerosing cholangitis 0.2531 4 (19%) : Bacteroides | Parabacteroides | Streptococcus | Veillonella 6 (32%) : Blautia | Coprococcus | Faecalibacterium | Lachnospiraceae | Phascolarctobacterium | Ruminococcus
Kidney stone 0.2506 5 (24%) : Alistipes | Bacteroides | Megamonas | Parabacteroides | Phascolarctobacterium 5 (26%) : Dialister | Faecalibacterium | Lactobacillus | Prevotella | Ruminococcus
Thyroid carcinoma 0.2506 5 (24%) : Alistipes | Anaerostipes | Blautia | Roseburia | Streptococcus 5 (26%) : Bacteroides | Enterobacteriaceae | Phascolarctobacterium | Prevotella | Sutterella

[Coverage Factors (Overlap > 0.10)]

FactorOverlapCommon increased OrganismCommon decreased Organism
Chemotherapy treatment 0.1053 0 (0%) 4 (21%) : Bacteroides | Bifidobacterium | Clostridium | Coprococcus
Protein powder consumption 0.1028 1 (5%) : Bacteroidetes 3 (16%) : Blautia | Coprococcus | Lachnospiraceae

Common References