Chronic kidney disease {40000186}

Record Keys
Definition:	Chronic kidney disease
Class:	[ ]

Details
Other Terms:	CKD
Initialisation date:	2020-10-13

Meta Information
ICD:	[ ]
MedDra ID:	10064848
MedDra Level:	pt

Notes

[ ]

Shared Notes

[1.11]
- In chronic kidney disease (CKD), the “healthy” microbiota structure is disrupted, and intestinal microbes produce large quantities of uremic solutes responsible for renal damage; on the other hand, the uremic state, fueled by reduced renal clearance, causes shifts in microbial metabolism and composition, hence creating a vicious cycle in which dysbiosis and renal dysfunction are progressively worsened.
[1.12]
- Saccharibacteria (per 1-SD higher in the log-transformed abundance) could potentially decrease the concentration of serum creatinine and increase the estimated glomerular filtration rate which might help improve renal function.

Common References

[1.1] Blood microbiome profile in CKD: A pilot study [2019] [Clinical Journal of the American Society of Nephrology] [Journal] [80000967]
[1.2] Carious status and supragingival plaque microbiota in hemodialysis patients [2018] [PLOS ONE] [Journal] [80000880]
[1.3] Alterations to the gut microbiota and their correlation with inflammatory factors in chronic kidney disease [2019] [Frontiers in Cellular and Infection Microbiology] [Journal] [80001140]
[1.4] Alteration of the gut microbiota in Chinese population with chronic kidney disease [2017] [Scientific Reports] [Journal] [80000616]
[1.5] Dysbiosis of the gut microbiome is associated with CKD5 and correlated with clinical indices of the disease: a case-controlled study [2019] [Journal of Translational Medicine] [Journal] [80001101]
[1.6] Gut microbiota composition and frailty in elderly patients with Chronic Kidney Disease [2020] [PLOS ONE] [Journal] [80001402]
[1.7] Altered gut microbiota and microbial biomarkers associated with chronic kidney disease [2018] [MicrobiologyOpen] [Journal] [80000867]
[1.8] Isolation and quantification of uremic toxin precursor-generating gut bacteria in chronic kidney disease patients [2020] [International journal of molecular sciences] [Journal] [80001379]
[1.9] Characterizing the gut microbiota in patients with chronic kidney disease [2020] [Abstract] [Postgraduate Medicine] [Journal] [80001316]
[1.10] A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression [2016] [Antonie van Leeuwenhoek (2016)] [Journal] [80000548]
[1.11] Intestinal microbiota and diabetic kidney diseases: role of microbiota and derived metabolites in the modulation of renal inflammation and disease progression [2021] [Review] [ScienceDirect] [Journal] [80001512]
[1.12] The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases [2020] [Review] [Microbiome] [Journal] [80000204]

Increased abundance of

‐ Acinetobacter Buffy coat ‎Human [1.1]
‐ Actinomyces naeslundii Supragingival plaque ‎Human [1.2]
‐ Actinomyces Supragingival plaque ‎Human [1.2]
‐ Alloprevotella Faeces ‎Human [1.3]
‐ Anaerotruncus Faeces ‎Human [1.4]
‐ Bacillus Buffy coat ‎Human [1.1]
‐ Bacteroides Faeces ‎Human [1.4]
‐ Bergeyella Supragingival plaque ‎Human [1.2]
‐ Bifidobacterium Faeces ‎Human [1.5]
‐ Citrobacter Faeces ‎Human [1.6]
‐ Cloacibacillus Faeces ‎Human [1.4]
‐ Clostridium cluster IV Faeces ‎Human [1.3]
‐ Clostridium innocuum Faeces ‎Human [1.7]
‐ Coprobacillus Faeces ‎Human [1.6]
‐ Corynebacterium Supragingival plaque ‎Human [1.2]
‐ Deltaproteobacteria Faeces ‎Human [1.4]
‐ Desulfovibrio Faeces ‎Human [1.3]
‐ Eggerthella Faeces ‎Human [1.7]
‐ Enterobacteriaceae Faeces ‎Human [1.8]
‐ Erysipelatoclostridium Faeces ‎Human [1.7]
‐ Escherichia coli Faeces ‎Human [1.8]
‐ Flavonifractor Faeces ‎Human [1.7]
‐ Hungatella Faeces ‎Human [1.9]
‐ Hyphomicrobium Buffy coat ‎Human [1.1]
‐ Intestinimonas Faeces ‎Human [1.9]
‐ Lachnoclostridium Faeces ‎Human [1.5]
‐ Lactobacillus fermentum Supragingival plaque ‎Human [1.2]
‐ Lactobacillus salivarius Supragingival plaque ‎Human [1.2]
‐ Lactobacillus vaginalis Supragingival plaque ‎Human [1.2]
‐ Lactobacillus Faeces ‎Human [1.6]
‐ Lysobacter Buffy coat ‎Human [1.1]
‐ Marvinbryantia Faeces ‎Human [1.4]
‐ Neisseria Faeces ‎Human [1.5]
‐ Parabacteroides Faeces ‎Human [1.4]
‐ Paraprevotella Faeces ‎Human [1.4]
‐ Parasporobacterium Faeces ‎Human [1.4]
‐ Pseudarcicella Buffy coat ‎Human [1.1]
‐ Pseudomonas Buffy coat ‎Human [1.1]
‐ Pseudomonas Faeces ‎Human [1.9]
‐ Rothia Supragingival plaque ‎Human [1.2]
‐ Ruminiclostridium Faeces ‎Human [1.7]
‐ Ruminococcus gnavus Faeces ‎Human [1.7]
‐ Ruminococcus torques Faeces ‎Human [1.6]
‐ Saccharibacteria ‎Ameliorative ‎Gut Lumen ‎Human
‐ Scardovia wiggsiae Supragingival plaque ‎Human [1.2]
‐ Sediminibacterium Buffy coat ‎Human [1.1]
‐ Sellimonas Faeces ‎Human [1.7]
‐ Serratia Buffy coat ‎Human [1.1]
‐ Shigella Faeces ‎Human [1.9]
‐ Streptococcus mitis Supragingival plaque ‎Human [1.2]
‐ Streptococcus mutans Supragingival plaque ‎Human [1.2]
‐ Streptococcus Faeces ‎Human [1.5]
‐ Subdoligranulum Faeces ‎Human [1.5]
‐ Weissella Faeces ‎Human [1.7]
‐ Yersinia Buffy coat ‎Human [1.1]

Decreased abundance of

‐ Akkermansia Faeces ‎Human [1.3]
‐ Alcaligenaceae Faeces ‎Human [1.4]
‐ anaerobacter Faeces ‎Human [1.4]
‐ Bacteroides fragilis Faeces ‎Human [1.4]
‐ Bacteroides Faeces ‎Human [1.5]
‐ Barnesiella Faeces ‎Human [1.4]
‐ Bifidobacterium Faeces ‎Human [1.4]
‐ Butyricicoccus Faeces ‎Human [1.4]
‐ Candidatus Buffy coat ‎Human [1.1]
‐ Carnobacterium Faeces ‎Human [1.7]
‐ Catenibacterium Faeces ‎Human [1.4]
‐ Clostridium coccoides group Faeces ‎Human [1.4]
‐ Clostridium Faeces ‎Human [1.4]
‐ Collinsella Faeces ‎Human [1.7]
‐ Coprococcus Faeces ‎Human [1.4]
‐ Corynebacterium Buffy coat ‎Human [1.1]
‐ Dialister Faeces ‎Human [1.4]
‐ Dorea Faeces ‎Human [1.4]
‐ Enterobacter Faeces ‎Human [1.5]
‐ Enterococcus Faeces ‎Human [1.4]
‐ Escherichia coli Faeces ‎Human [1.4]
‐ Eubacterium coprostanoligenes Faeces ‎Human [1.7]
‐ Eubacterium hallii Faeces ‎Human [1.7]
‐ Eubacterium rectale Faeces ‎Human [1.7]
‐ Faecalibacterium prausnitzii Faeces ‎Human [1.6]
‐ Faecalibacterium Faeces ‎Human [1.4]
‐ Hallella Faeces ‎Human [1.4]
‐ Lachnospira Faeces ‎Human [1.7]
‐ Megamonas Faeces ‎Human [1.9]
‐ Oribacterium Faeces ‎Human [1.4]
‐ Paracoccus Buffy coat ‎Human [1.1]
‐ Parasutterella Faeces ‎Human [1.4]
‐ Pasteurellaceae Faeces ‎Human [1.4]
‐ Prevotellaceae Faeces ‎Human [1.9]
‐ Prevotella Faeces ‎Human [1.4]
‐ Pseudomonadales Faeces ‎Human [1.4]
‐ Pseudomonas Faeces ‎Human [1.4]
‐ Pyramidobacter Faeces ‎Human [1.9]
‐ Rikenellaceae Faeces ‎Human [1.9]
‐ Romboutsia Faeces ‎Human [1.7]
‐ Roseburia Faeces ‎Human [1.10]
‐ Ruminococcaceae Faeces ‎Human [1.9]
‐ Ruminococcus Faeces ‎Human [1.7]
‐ Shigella Faeces ‎Human [1.5]
‐ Slackia Faeces ‎Human [1.4]
‐ Sphingomonas Buffy coat ‎Human [1.1]
‐ Stenotrophomonas Buffy coat ‎Human [1.1]
‐ Streptococcus Faeces ‎Human [1.8]
‐ Subdoligranulum Faeces ‎Human [1.7]
‐ Tyzzerella Buffy coat ‎Human [1.1]
‐ Tyzzerella Faeces ‎Human [1.7]

Related Factor

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Subclass

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Related Metabolome

‐ Creatinin

Shared References

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References

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Chronic kidney disease {40000186}

Record Keys

Details

Meta Information

Notes

Shared Notes

Common References