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Microbiome & Chronic Diseases

Evidence Based Medicine
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Chronic kidney disease {40000186}

Record Keys


Definition:
Chronic kidney disease
Class:[  ]

Details


Other Terms:
CKD
Initialisation date:
2020-10-13

Meta Information


ICD:[  ]
MedDra ID:
10064848
MedDra Level:
pt

Notes


[  ]

Shared Notes


  • [1.12
    - In chronic kidney disease (CKD), the “healthy” microbiota structure is disrupted, and intestinal microbes produce large quantities of uremic solutes responsible for renal damage; on the other hand, the uremic state, fueled by reduced renal clearance, causes shifts in microbial metabolism and composition, hence creating a vicious cycle in which dysbiosis and renal dysfunction are progressively worsened.
  • [1.13
    - Saccharibacteria (per 1-SD higher in the log-transformed abundance) could potentially decrease the concentration of serum creatinine and increase the estimated glomerular filtration rate which might help improve renal function.
  • [1.11
    - Curcumin > significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-γ, and IL-4) and lipid peroxidation.
    - After 6 months of curcumin supplementation > significantly lower Escherichia-Shigella and significantly higher Lachnoclostridium .
    - In the last 3 months of supplementation > significantly higher Lactobacillaceae spp..


[Coverage other Diseases (Overlap > 0.25)]

DiseaseOverlapCommon increased OrganismCommon decreased Organism
Chronic kidney disease 1.0000 54 (100%) : Acinetobacter | Actinomyces | Actinomyces naeslundii | Alloprevotella | Anaerotruncus | Bacillus | Bacteroides | Bergeyella | Bifidobacterium | Citrobacter | Cloacibacillus | Clostridium cluster IV | Clostridium innocuum | Coprobacillus | Corynebacterium | Deltaproteobacteria | Desulfovibrio | Eggerthella | Enterobacteriaceae | Erysipelatoclostridium | Escherichia coli | Flavonifractor | Hungatella | Hyphomicrobium | Intestinimonas | Lachnoclostridium | Lactobacillus | Lactobacillus fermentum | Lactobacillus salivarius | Lactobacillus vaginalis | Lysobacter | Marvinbryantia | Neisseria | Parabacteroides | Paraprevotella | Parasporobacterium | Pseudarcicella | Pseudomonas | Rothia | Ruminiclostridium | Ruminococcus gnavus | Ruminococcus torques | Saccharibacteria | Scardovia wiggsiae | Sediminibacterium | Sellimonas | Serratia | Shigella | Streptococcus | Streptococcus mitis | Streptococcus mutans | Subdoligranulum | Weissella | Yersinia 50 (100%) : Akkermansia | Alcaligenaceae | anaerobacter | Bacteroides | Bacteroides fragilis | Barnesiella | Bifidobacterium | Butyricicoccus | Candidatus | Carnobacterium | Catenibacterium | Clostridium | Clostridium coccoides group | Collinsella | Coprococcus | Corynebacterium | Dialister | Dorea | Enterobacter | Enterococcus | Escherichia coli | Eubacterium coprostanoligenes | Eubacterium hallii | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Hallella | Lachnospira | Megamonas | Oribacterium | Paracoccus | Parasutterella | Pasteurellaceae | Prevotella | Prevotellaceae | Pseudomonadales | Pseudomonas | Pyramidobacter | Rikenellaceae | Romboutsia | Roseburia | Ruminococcaceae | Ruminococcus | Shigella | Slackia | Sphingomonas | Stenotrophomonas | Streptococcus | Subdoligranulum | Tyzzerella
Crohn's disease 0.4374 17 (31%) : Acinetobacter | Actinomyces | Anaerotruncus | Bifidobacterium | Citrobacter | Eggerthella | Enterobacteriaceae | Escherichia coli | Lactobacillus | Lactobacillus fermentum | Pseudomonas | Rothia | Ruminococcus gnavus | Ruminococcus torques | Shigella | Streptococcus | Streptococcus mutans 28 (56%) : Akkermansia | Bacteroides | Bacteroides fragilis | Bifidobacterium | Clostridium | Clostridium coccoides group | Collinsella | Coprococcus | Dialister | Dorea | Enterobacter | Enterococcus | Eubacterium hallii | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Hallella | Lachnospira | Pasteurellaceae | Prevotella | Pseudomonas | Rikenellaceae | Roseburia | Ruminococcaceae | Ruminococcus | Stenotrophomonas | Streptococcus | Subdoligranulum
Autism 0.3889 15 (28%) : Bacillus | Bacteroides | Bifidobacterium | Clostridium innocuum | Corynebacterium | Desulfovibrio | Enterobacteriaceae | Lactobacillus | Parabacteroides | Pseudomonas | Rothia | Ruminococcus gnavus | Ruminococcus torques | Shigella | Streptococcus 25 (50%) : Akkermansia | Bacteroides | Bacteroides fragilis | Barnesiella | Bifidobacterium | Butyricicoccus | Collinsella | Coprococcus | Corynebacterium | Dialister | Enterococcus | Escherichia coli | Eubacterium coprostanoligenes | Eubacterium rectale | Faecalibacterium prausnitzii | Oribacterium | Prevotella | Prevotellaceae | Romboutsia | Roseburia | Ruminococcaceae | Shigella | Streptococcus | Subdoligranulum | Tyzzerella
Colorectal cancer 0.3596 14 (26%) : Acinetobacter | Actinomyces | Anaerotruncus | Bacteroides | Bifidobacterium | Coprobacillus | Desulfovibrio | Enterobacteriaceae | Escherichia coli | Lactobacillus | Marvinbryantia | Paraprevotella | Pseudomonas | Streptococcus 23 (46%) : Akkermansia | Bacteroides | Bacteroides fragilis | Bifidobacterium | Collinsella | Coprococcus | Dialister | Dorea | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Lachnospira | Megamonas | Parasutterella | Prevotella | Pseudomonas | Rikenellaceae | Roseburia | Ruminococcaceae | Ruminococcus | Sphingomonas | Stenotrophomonas | Streptococcus
Parkinson's Disease 0.3567 18 (33%) : Acinetobacter | Anaerotruncus | Bacteroides | Bifidobacterium | Citrobacter | Clostridium cluster IV | Desulfovibrio | Enterobacteriaceae | Lactobacillus | Lactobacillus fermentum | Lactobacillus salivarius | Parabacteroides | Paraprevotella | Ruminococcus torques | Shigella | Streptococcus | Streptococcus mutans | Subdoligranulum 19 (38%) : Bacteroides fragilis | Clostridium | Collinsella | Coprococcus | Corynebacterium | Dorea | Eubacterium hallii | Faecalibacterium | Faecalibacterium prausnitzii | Lachnospira | Pasteurellaceae | Prevotella | Prevotellaceae | Roseburia | Ruminococcaceae | Ruminococcus | Stenotrophomonas | Streptococcus | Tyzzerella
HIV infection 0.3126 10 (19%) : Acinetobacter | Anaerotruncus | Citrobacter | Corynebacterium | Enterobacteriaceae | Lactobacillus | Paraprevotella | Serratia | Shigella | Streptococcus 22 (44%) : Akkermansia | Bacteroides | Barnesiella | Bifidobacterium | Clostridium | Collinsella | Coprococcus | Dialister | Dorea | Faecalibacterium | Lachnospira | Parasutterella | Prevotella | Pseudomonas | Pyramidobacter | Rikenellaceae | Romboutsia | Roseburia | Ruminococcaceae | Ruminococcus | Shigella | Streptococcus
Ulcerative Colitis 0.3081 16 (30%) : Actinomyces | Bacteroides | Bifidobacterium | Citrobacter | Coprobacillus | Desulfovibrio | Eggerthella | Enterobacteriaceae | Erysipelatoclostridium | Escherichia coli | Lactobacillus | Rothia | Ruminococcus gnavus | Ruminococcus torques | Shigella | Streptococcus 16 (32%) : Bacteroides | Bacteroides fragilis | Bifidobacterium | Catenibacterium | Clostridium coccoides group | Coprococcus | Dialister | Enterococcus | Eubacterium rectale | Faecalibacterium prausnitzii | Lachnospira | Prevotella | Pseudomonas | Rikenellaceae | Roseburia | Streptococcus
Type 2 diabetes 0.3059 19 (35%) : Acinetobacter | Actinomyces | Actinomyces naeslundii | Bacteroides | Bifidobacterium | Corynebacterium | Eggerthella | Escherichia coli | Lactobacillus | Lactobacillus salivarius | Neisseria | Parabacteroides | Pseudomonas | Ruminococcus gnavus | Sediminibacterium | Shigella | Streptococcus | Streptococcus mutans | Subdoligranulum 13 (26%) : Akkermansia | Bifidobacterium | Collinsella | Coprococcus | Dorea | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Lachnospira | Megamonas | Prevotella | Pseudomonas | Streptococcus
Irritable bowel syndrome 0.2596 14 (26%) : Acinetobacter | Actinomyces | Bacteroides | Bifidobacterium | Citrobacter | Enterobacteriaceae | Escherichia coli | Lachnoclostridium | Lactobacillus | Marvinbryantia | Paraprevotella | Parasporobacterium | Ruminococcus gnavus | Streptococcus 13 (26%) : Bacteroides | Bacteroides fragilis | Bifidobacterium | Butyricicoccus | Coprococcus | Dorea | Faecalibacterium | Lachnospira | Oribacterium | Prevotellaceae | Roseburia | Ruminococcaceae | Streptococcus
Obesity 0.2526 10 (19%) : Bacillus | Bacteroides | Bifidobacterium | Corynebacterium | Lactobacillus | Parabacteroides | Pseudomonas | Ruminococcus torques | Streptococcus mitis | Streptococcus mutans 16 (32%) : Akkermansia | Bacteroides | Barnesiella | Bifidobacterium | Coprococcus | Dialister | Eubacterium hallii | Faecalibacterium | Faecalibacterium prausnitzii | Lachnospira | Megamonas | Prevotella | Roseburia | Ruminococcaceae | Ruminococcus | Streptococcus
Multiple Sclerosis 0.2511 12 (22%) : Actinomyces | Anaerotruncus | Bacteroides | Bifidobacterium | Clostridium cluster IV | Coprobacillus | Desulfovibrio | Eggerthella | Lactobacillus | Parabacteroides | Shigella | Streptococcus 14 (28%) : Bacteroides | Butyricicoccus | Clostridium | Dialister | Dorea | Eubacterium rectale | Faecalibacterium | Faecalibacterium prausnitzii | Lachnospira | Prevotella | Pseudomonas | Roseburia | Ruminococcaceae | Slackia

Common References