Alcoholic Hepatitis {40000181}

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Definition:	Alcoholic Hepatitis
Class:	[ ]

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Other Terms:	[ ]
Authoring date:	2020-09-25

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ICD:	[ ]
Category:	Gastroenterologic, DietNutrition, Metabolomics
MedDra ID:	10019717
MedDra Level:	pt

Notes

- Alcoholic hepatitis patients with more severe disease had significantly decreased relative abundances of Akkermansia while the relative abundance of Veillonella was increased. We observed a reduction in the Bacteroides abundance (Padjust = 0.048) and Shannon diversity (Padjust = 0.018) in antibiotic-treated patients and patients receiving steroids had an increase in Veillonella abundance (Padjust = 0.005), which was both independent of potentially confounding factors. (1)

Common References

[1.1] Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis [2018] [80000969] [Alimentary Pharmacology & Therapeutics]
[1.2] Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis [2018] [80000689] [Scientific Reports]
[1.3] The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis [2018] [80000726] [Hepatology]
[1.4] Intestinal fungal dysbiosis and systemic immune response to fungi in patients with alcoholic hepatitis [2019] [80001181] [Hepatology]

Increased abundance of

‐ Actinomyces Faeces ‎Human [1.1]
‐ Aggregatibacter Faeces ‎Human [1.2]
‐ Anaerococcus Blood ‎Human [1.3]
‐ Atopobium Faeces ‎Human [1.2]
‐ Bifidobacterium Faeces ‎Human [1.1, 1.2]
‐ Bradyrhizobiaceae Blood ‎Human [1.3]
‐ Candida Faeces ‎Human [1.4]
‐ Chitinophagaceae Blood ‎Human [1.3]
‐ Clostridium group XI Blood ‎Human [1.3]
‐ Corynebacteriaceae Blood ‎Human [1.3]
‐ Dermabacteraceae Blood ‎Human [1.3]
‐ Dorea Faeces ‎Human [1.1]
‐ Enterobacteriaceae Faeces ‎Human [1.1]
‐ Enterococcus Faeces ‎Human [1.2]
‐ Fusobacteriales Blood ‎Human [1.3]
‐ Haemophilus Faeces ‎Human [1.1, 1.2]
‐ Lachnospiraceae incertae sedis Blood ‎Human [1.3]
‐ Lactobacillus Faeces ‎Human [1.1, 1.2]
‐ Lactococcus Faeces ‎Human [1.1]
‐ Leptotrichiaceae Blood ‎Human [1.3]
‐ Microbacterium Blood ‎Human [1.3]
‐ Micromonosporaceae Blood ‎Human [1.3]
‐ Neisseriaceae Blood ‎Human [1.3]
‐ Peptostreptococcaceae Blood ‎Human [1.3]
‐ Rothia Faeces ‎Human [1.1, 1.2]
‐ Streptococcus Faeces ‎Human [1.2]
‐ Turicella Blood ‎Human [1.3]
‐ Veillonella ‎Gut Lumen ‎Human

Decreased abundance of

‐ Acinetobacter Blood ‎Human [1.3]
‐ Akkermansia ‎Gut Lumen ‎Human
‐ Bacteroides ‎Gut Lumen ‎Human
‐ Bacteroidetes Blood ‎Human [1.3]
‐ Bilophila Faeces ‎Human [1.1, 1.2]
‐ Christensenellaceae Faeces ‎Human [1.1]
‐ Debaryomyces Faeces ‎Human [1.4]
‐ Desulfovibrio Faeces ‎Human [1.2]
‐ Flavobacterium Blood ‎Human [1.3]
‐ Nocardioides Blood ‎Human [1.3]
‐ Odoribacter Faeces ‎Human [1.2]
‐ Oscillospira Faeces ‎Human [1.1, 1.2]
‐ Parabacteroides Faeces ‎Human [1.1, 1.2]
‐ Penicillium Faeces ‎Human [1.4]
‐ Prevotella Blood ‎Human [1.3]
‐ Ruminococcus Faeces ‎Human [1.2]
‐ Saccharomyces Faeces ‎Human [1.4]

References

(1) Changes in the fecal bacterial microbiota associated with disease severity in alcoholic hepatitis patients [Abstract] [2020]

Alcoholic Hepatitis {40000181}

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