MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Alcoholic Hepatitis {40000181}

Record Keys


Definition:
Alcoholic Hepatitis
Class:[  ]

Details


Other Terms:[  ]
Initialisation date:
2020-09-25

Meta Information


ICD:[  ]
Category:
Gastroenterology, DietNutrition, Metabolomics
MedDra ID:
10019717
MedDra Level:
pt

Notes


- Alcoholic hepatitis patients with more severe disease had significantly decreased relative abundances of Akkermansia while the relative abundance of Veillonella was increased. We observed a reduction in the Bacteroides abundance (Padjust = 0.048) and Shannon diversity (Padjust = 0.018) in antibiotic-treated patients and patients receiving steroids had an increase in Veillonella abundance (Padjust = 0.005), which was both independent of potentially confounding factors. (1)

Shared Notes


  • [1.5
    - CIG could inhibit the activities of AST, ALT and MDA, promote the activities of SOD, CAT and GSH, and reduce oxidative damage to the liver. CIG could significantly alter intestinal microbial diversity, reduce the presence of serum LPS and levels of TNF-α, IL-1β and IL-6 in the liver. In addition,
    - CIG supplementation reduced the imbalance of intestinal microbiota caused by alcohol and improved intestinal barrier function.

Common References