Alcoholic Hepatitis {40000181}

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Definition:	Alcoholic Hepatitis
Class:	[ ]

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Other Terms:	[ ]
Initialisation date:	2020-09-25

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ICD:	[ ]
Category:	Gastroenterology, DietNutrition, Metabolomics
MedDra ID:	10019717
MedDra Level:	pt

Notes

- Alcoholic hepatitis patients with more severe disease had significantly decreased relative abundances of Akkermansia while the relative abundance of Veillonella was increased. We observed a reduction in the Bacteroides abundance (Padjust = 0.048) and Shannon diversity (Padjust = 0.018) in antibiotic-treated patients and patients receiving steroids had an increase in Veillonella abundance (Padjust = 0.005), which was both independent of potentially confounding factors. (1)

Shared Notes

[1.5]
- CIG could inhibit the activities of AST, ALT and MDA, promote the activities of SOD, CAT and GSH, and reduce oxidative damage to the liver. CIG could significantly alter intestinal microbial diversity, reduce the presence of serum LPS and levels of TNF-α, IL-1β and IL-6 in the liver. In addition,
- CIG supplementation reduced the imbalance of intestinal microbiota caused by alcohol and improved intestinal barrier function.

Common References

[1.1] Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis [2018] [Alimentary Pharmacology & Therapeutics] [Journal] [80000969]
[1.2] Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis [2018] [Scientific Reports] [Journal] [80000689]
[1.3] The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis [2018] [Hepatology] [Journal] [80000726]
[1.4] Intestinal fungal dysbiosis and systemic immune response to fungi in patients with alcoholic hepatitis [2019] [Hepatology] [Journal] [80001181]
[1.5] An iridoid glycoside from Cornus officinalis balances intestinal microbiome disorder and alleviates alcohol-induced liver injury [2021] [Research] [Journal of Functional Foods] [Journal] [80001830]

Increased abundance of

‐ Actinomyces Faeces ‎Human [1.1]
‐ Aggregatibacter Faeces ‎Human [1.2]
‐ Anaerococcus Blood ‎Human [1.3]
‐ Atopobium Faeces ‎Human [1.2]
‐ Bifidobacterium Faeces ‎Human [1.2]
‐ Bradyrhizobiaceae Blood ‎Human [1.3]
‐ Candida Faeces ‎Human [1.4]
‐ Chitinophagaceae Blood ‎Human [1.3]
‐ Clostridium group XI Blood ‎Human [1.3]
‐ Corynebacteriaceae Blood ‎Human [1.3]
‐ Dermabacteraceae Blood ‎Human [1.3]
‐ Dorea Faeces ‎Human [1.1]
‐ Enterobacteriaceae Faeces ‎Human [1.1]
‐ Enterococcus Faeces ‎Human [1.2]
‐ Fusobacteriales Blood ‎Human [1.3]
‐ Haemophilus Faeces ‎Human [1.2]
‐ Lachnospiraceae incertae sedis Blood ‎Human [1.3]
‐ Lactobacillus Faeces ‎Human [1.2]
‐ Lactococcus Faeces ‎Human [1.1]
‐ Leptotrichiaceae Blood ‎Human [1.3]
‐ Microbacterium Blood ‎Human [1.3]
‐ Micromonosporaceae Blood ‎Human [1.3]
‐ Neisseriaceae Blood ‎Human [1.3]
‐ Peptostreptococcaceae Blood ‎Human [1.3]
‐ Rothia Faeces ‎Human [1.2]
‐ Streptococcus Faeces ‎Human [1.2]
‐ Turicella Blood ‎Human [1.3]
‐ Veillonella ‎Gut Lumen ‎Human

Decreased abundance of

‐ Acinetobacter Blood ‎Human [1.3]
‐ Akkermansia ‎Gut Lumen ‎Human
‐ Bacteroides ‎Gut Lumen ‎Human
‐ Bacteroidetes Blood ‎Human [1.3]
‐ Bilophila Faeces ‎Human [1.2]
‐ Christensenellaceae Faeces ‎Human [1.1]
‐ Debaryomyces Faeces ‎Human [1.4]
‐ Desulfovibrio Faeces ‎Human [1.2]
‐ Flavobacterium Blood ‎Human [1.3]
‐ Nocardioides Blood ‎Human [1.3]
‐ Odoribacter Faeces ‎Human [1.2]
‐ Oscillospira Faeces ‎Human [1.2]
‐ Parabacteroides Faeces ‎Human [1.2]
‐ Penicillium Faeces ‎Human [1.4]
‐ Prevotella Blood ‎Human [1.3]
‐ Ruminococcus Faeces ‎Human [1.2]
‐ Saccharomyces Faeces ‎Human [1.4]

Related Factor

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Subclass

[ ]

Related Metabolome

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Shared References

[ ]

References

(1) Changes in the fecal bacterial microbiota associated with disease severity in alcoholic hepatitis patients [Abstract] [2020]

Alcoholic Hepatitis {40000181}

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