Microbiome & Chronic Diseases

Evidence Based Medicine

Inflammatory bowel disease {40000180}

Record Keys

Inflammatory bowel disease
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ICD:[  ]
Gastroenterologic, Rheumatologic
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Shared Notes

  • [1.13
    - Seven bacterial species correlated with expression levels of Th17 effector cytokines, IL-17A and IL-17F.
    - The seven associated species include Ruminococcus gnavus, Escherichia coli, Lachnospiraceae bacterium, Clostridium hathewayi, Bacteroides faecis, Bacteroides vulgatus, and Akkermansia muciniphila. All of the species were positively associated with IL-17A/ IL-17F except Akkermansia muciniphila, suggesting these species are proinflammatory, while Akkermansia muciniphila is anti-inflammatory.
  • [1.14
    - Ruminococcus torques and Ruminococcus gnavus, two prominent species in IBD19, were also differentially abundant in dysbiotic CD and UC, respectively as well as showing differences in abundance, including Clostridium hathewayi, Clostridium bolteae, and R. gnavus. All had significantly increased expression during dysbiosis, and thus their roles in IBD may be more pronounced than suggested solely by their differences in genomic abundance.
    - The reduction in butyrate in particular is consistent with the previously observed depletion of butyrate producers such as F. prausnitzii and R. hominis.
  • [1.15
    - Vitamin D receptor (VDR) regulates the biological actions of the active VitD (1α,25-dihydroxyvitamin D3), and is involved in the genetic, environmental, immune, and microbial aspects of IBD.
  • [1.16
    - Patients with inflammatory bowel disease are more likely to develop Parkinson disease.
  • [1.17
    - Translocation of oral bacteria and yeasts to the lower GI tract may trigger inflammation in susceptible hosts, providing a mechanistic link to the development of IBD.
    - Conversely, dysbiosis of the oral microbiome may occur, possibly as a result of inflammatory responses and could represent a useful source of biomarkers of GI health.
  • [1.18
    - Some pro-inflammatory bacterial species are coated with a specific type of immune molecules called immunoglobulins A (IgA) which can be used as a proxy to identify microbes that stimulate immune responses
    - IgA coating of Oscillospira was associated with a delay in time to surgery in IBD
  • [1.19
    - Gut metagenomic profiles of patients with inflammatory bowel disease (IBD) are highly correlated with fecal calprotectin levels, a biomarker for severity of inflammation in IBD.
  • [1.20
    - reduced levels of Christensenellaceae, Odoribacter, and Gemmiger and increased abundance of Peptostreptococcaceae.
    - In IBD, 12 features were identified in all three comparisons, including increased Peptostreptococcaceae, and decreased levels of Mogibacteriaceae and Gemmiger

Common References