MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Ulcerative Colitis {40000109}

Record Keys
Definition:
Ulcerative Colitis
Class:[  ]

Details
Other Terms:[  ]
Initialisation date:
2020-09-06

Links

Meta Information
ICD:[  ]
Category:
Gastroenterology, Rheumatology
MedDra ID:
10009900
MedDra Level:
pt

Notes

[  ]

Shared Notes

  • [1.37] 
    - A positive association between a “high sugar and soft drinks” pattern and UC risk
    - When considering the foods most associated with the pattern, high consumers of sugar and soft drinks were at higher UC risk only if they had low vegetables intakes.
  • [1.3] 
    - Functional analysis revealed increased fecal proteolytic and elastase activity before UC onset.
    - Elastase activity inversely correlated with the relative abundance of Adlercreutzia.
    - Elastase activity directly correlated with known proteolytic taxa, such as Bacteroides vulgatus and high elastase activity was confirmed in Bacteroides isolates from fecal samples.
    - Mice colonized with or born from pre-UC colonized dams developed higher fecal proteolytic activity and an inflammatory immune tone compared with HC colonized mice.
  • [1.38] 
    - Significantly higher abundances of Bifidobacterium in UC.
  • [1.39] 
    - The safety and tolerability of SER-287 were similar to placebo.
    - SER-287 after vancomycin was significantly more effective than placebo for induction of remission in patients with active mild to moderate UC.
  • [1.36] 
    - Red meat is metabolized by intestinal bacteria with production of branched-chain amino acids and toxic elements like hydrogen sulfide, nitrous compounds, amines, and ammonia that induce DNA damage of eucaryotic cells and promote colon inflammation in murine models.
    - Large epidemiological data confirmed the association between high consumption of red meat and risk of IBD development, in particular UC , where it was found to affect also the relapse risk.
  • [1.40] 
    - Intestinal microbiota in UC is associated with abundant small atypical N-glycans.
    - Higher level of microbiota-associated atypical N-glycans in UC than controls.
    - Atypical N-glycans act as promising biomarker candidates for pediatric UC.
  • [1.41] 
    - in patients suffering from ulcerative colitis (UC), P-gp expression coupled to the reduction of epithelial-derived anti-inflammatory endocannabinoids and luminal content (e.g., microbes or their metabolites) with a reduced capability to induce P-gp expression.

Common References