Ulcerative Colitis {40000109}

Record Keys
Definition:	Ulcerative Colitis
Class:	[ ]

Details
Other Terms:	[ ]
Authoring date:	2020-09-06

Links
Wickipedia Merck Manual

Meta Information
ICD:	[ ]
Category:	Gastroenterologic, Rheumatologic
MedDra ID:	10009900
MedDra Level:	pt

Notes

[ ]

Shared Notes

[1.37]
- Significantly higher abundances of Bifidobacterium in UC.
[1.38]
- A positive association between a “high sugar and soft drinks” pattern and UC risk
- When considering the foods most associated with the pattern, high consumers of sugar and soft drinks were at higher UC risk only if they had low vegetables intakes.
[1.3]
- Functional analysis revealed increased fecal proteolytic and elastase activity before UC onset.
- Elastase activity inversely correlated with the relative abundance of Adlercreutzia.
- Elastase activity directly correlated with known proteolytic taxa, such as Bacteroides vulgatus and high elastase activity was confirmed in Bacteroides isolates from fecal samples.
- Mice colonized with or born from pre-UC colonized dams developed higher fecal proteolytic activity and an inflammatory immune tone compared with HC colonized mice.
[1.39]
- The safety and tolerability of SER-287 were similar to placebo.
- SER-287 after vancomycin was significantly more effective than placebo for induction of remission in patients with active mild to moderate UC.

Common References

[1.1] A comparative study of the gut microbiota in immune-mediated inflammatory diseases - does a common dysbiosis exist? [2018] [80000942] [Microbiome]
[1.2] Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers [2015] [80000658] [Gut]
[1.3] Novel fecal biomarkers that precede clinical diagnosis of ulcerative colitis. [2021] [Research] [80001572] [Gastroenterology]
[1.4] Combined signature of the fecal microbiome and plasma metabolome in patients with ulcerative colitis [2019] [80001189] [Medical Science Monitor]
[1.5] Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease [2018] [80000679] [Journal of Gastroenterology]
[1.6] Disease-specific alterations in the enteric virome in inflammatory Bowel disease [2015] [Research] [80001194] [Cell]
[1.7] Characteristics of fecal and mucosa-associated microbiota in Chinese patients with inflammatory bowel disease [2014] [80000665] [Medicine]
[1.8] Alterations of mucosal microbiota in the colon of patients with inflammatory bowel disease revealed by real time polymerase chain reaction amplification of 16S ribosomal ribonucleic acid. [2015] [80000597] [Indian J Med Res]
[1.9] Gut microbiota dysbiosis in children with relapsing idiopathic nephrotic syndrome [2018] [80000692] [American Journal of Nephrology]
[1.10] Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease [2005] [80000610] [Journal of Clinical Microbiology]
[1.11] Alterations in diversity of the oral microbiome in pediatric inflammatory bowel disease [2012] [80000404] [Inflammatory Bowel Diseases]
[1.12] A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis [2014] [80000592] [Gut]
[1.13] Comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis [2018] [80000716] [Journal of Gastroenterology and Hepatology]
[1.14] Fecal microbiota in pediatric inflammatory bowel disease and its relation to inflammation [2015] [80000523] [The American Journal of Gastroenterology]
[1.15] Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment [2012] [80000991] [Genome Biology]
[1.16] Gut microbiota differs between children with inflammatory bowel disease and healthy siblings in taxonomic and functional composition: a metagenomic analysis [2017] [80000660] [American journal of physiology. Gastrointestinal and liver physiology]
[1.17] Desulfovibrio bacterial species are increased in ulcerative colitis [2010] [80000288] [Diseases of the Colon & Rectum]
[1.18] Characterization of fungal dysbiosis in Japanese patients with inflammatory bowel disease [2019] [80000995] [Journal of Gastroenterology]
[1.19] The microbiome reflects diagnosis and predicts disease severity in paediatric onset inflammatory bowel disease [2019] [80001185] [Scandinavian Journal of Gastroenterology]
[1.20] Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody. [2002] [80000287] [Journal of Gastroenterology and Hepatology]
[1.21] Increased Gardnerella vaginalis urogenital biofilm in inflammatory bowel disease [2014] [80000633] [Journal of Crohn's and Colitis]
[1.22] Metagenomic analysis of intestinal mucosa revealed a specific eukaryotic gut virome signature in early-diagnosed inflammatory bowel disease [2018] [80000803] [Gut microbes]
[1.23] Terminal Restriction Fragment length Polymorphism Analysis of the Gut Microbiota Profiles of Pediatric Patients with Inflammatory Bowel Disease [2012] [80000619] [Digestion]
[1.24] Gut mucosal virome alterations in ulcerative colitis [2019] [80000989] [Gut]
[1.25] Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers [2014] [80000489] [DNA Research]
[1.26] Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria [2010] [80000253] [The American Journal of Gastroenterology]
[1.27] Subgingival microflora in inflammatory bowel disease patients with untreated periodontitis. [2013] [80000235] [European Journal of Periodontology & Hepatology]
[1.28] Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis [2017] [80000752] [World journal of gastroenterology]
[1.29] Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease [2020] [80001325] [Nature communications]
[1.30] A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes [2010] [80000284] [Gastroenterology]
[1.31] A single species of Clostridium subcluster XIVa decreased in ulcerative colitits patients [2016] [80000620] [Inflammatory Bowel Diseases]
[1.32] Low counts of faecalibacterium prausnitzii in Colitis microbiota [2009] [80000286] [Inflammatory Bowel Diseases]
[1.33] Altered fecal microbiota in paediatric inflammatory bowel disease [2015] [80000564] [Journal of Crohn's and Colitis]
[1.34] Specificities of the fecal microbiota in inflammatory bowel disease [2006] [80000283] [Inflammatory Bowel Diseases]
[1.35] Clostridium leptum group bacteria abundance and diversity in the fecal microbiota of patients with inflammatory bowel disease: a case-control study in India [2013] [80000611] [BMC Gastroenterology]
[1.36] Dysbiosis of the salivary microbiota in pediatric-onset primary sclerosing cholangitis and its potential as a biomarker [2018] [80000746] [Scientific Reports]
[1.37] A comparative study of the gut microbiota in immune-mediated inflammatory diseases—does a common dysbiosis exist? [2018] [Research] [80000038] [Microbiome]
[1.38] Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe: Results from the EPIC Study [2015] [Research] [80001533] [Inflammatory Bowel Diseases]
[1.39] A Phase 1b Safety Study of SER-287, a Spore-Based Microbiome Therapeutic, for Active Mild to Moderate Ulcerative Colitis [2021] [Research] [80001603] [Gastroenterology]

Increased abundance of

‐ Actinomyces Faeces ‎Human [1.1]

‐ Actinomycetaceae Tissue biopsie ‎Human [1.2]

‐ Adlercreutzia ‎Ameliorative Faeces ‎Human [1.3]

‐ Aggregatibacter Faeces ‎Human [1.4]

‐ Akkermansia Faeces ‎Human [1.4]

‐ Anaerofustis Faeces ‎Human [1.1]

‐ Anaerostipes Brush sample ‎Human [1.5]

‐ Anelloviridae Faeces ‎Human [1.6]

‐ Bacteroides Faeces ‎Human [1.7]

‐ Bacteroides Tissue biopsie ‎Human [1.8]

‐ Bacteroides fragilis Faeces ‎Human [1.9]

‐ Bacteroides fragilis Tissue biopsie ‎Human [1.10]

‐ Bacteroides vulgatus ‎Causal Faeces ‎Human [1.3]

‐ Bacteroidetes Tongue scrape sample ‎Human [1.11]

‐ Bifidobacteriaceae Tissue biopsie ‎Human [1.2]

‐ Bifidobacterium

‐ Bifidobacterium Faeces ‎Human [1.1]

‐ Bifidobacterium Brush sample ‎Human [1.5, 1.5]

‐ Bifidobacterium longum Faeces ‎Human [1.12]

‐ Blautia Brush sample ‎Human [1.5, 1.5]

‐ Blautia Faeces ‎Human [1.4, 1.7]

‐ Burkholderia Faeces ‎Human [1.4]

‐ Butyricicoccus Brush sample ‎Human [1.5]

‐ Citrobacter Brush sample ‎Human [1.5, 1.5]

‐ Cloacibacterium Tissue biopsie ‎Human [1.13]

‐ Clostridiaceae Tissue biopsie ‎Human [1.2]

‐ Clostridioides difficile Faeces ‎Human [1.14]

‐ Clostridium Faeces ‎Human [1.15]

‐ Clostridium ramosum Faeces ‎Human [1.16]

‐ Coprobacillus Brush sample ‎Human [1.5]

‐ Desulfovibrio Tissue biopsie ‎Human [1.17, 1.17]

‐ Dipodascus Faeces ‎Human [1.18]

‐ Dorea Faeces ‎Human [1.4]

‐ Eggerthella Brush sample ‎Human [1.5]

‐ Eggerthella Faeces ‎Human [1.1]

‐ Enterobacteriaceae Tissue biopsie ‎Human [1.2]

‐ Enterococcus Faeces ‎Human [1.7]

‐ Entyloma Faeces ‎Human [1.18]

‐ Erysipelatoclostridium Faeces ‎Human [1.4]

‐ Erysipelotrichaceae Brush sample ‎Human [1.5]

‐ Escherichia coli Tissue biopsie ‎Human [1.8]

‐ Escherichia coli Faeces ‎Human [1.16]

‐ Eubacterium ruminantium Faeces ‎Human [1.4]

‐ Faecalibacterium Brush sample ‎Human [1.5]

‐ Faecalicoccus Faeces ‎Human [1.1]

‐ Flavonifractor plautii Faeces ‎Human [1.19]

‐ Fusobacterium nucleatum Faeces ‎Human [1.16]

‐ Fusobacterium varium Tissue biopsie ‎Human [1.20]

‐ Gardnerella vaginalis Urine ‎Human [1.21]

‐ Gemella Faeces ‎Human [1.1, 1.4]

‐ Gemmiger Brush sample ‎Human [1.5]

‐ Haemophilus Faeces ‎Human [1.4]

‐ Hepadnaviridae Tissue biopsie ‎Human [1.22]

‐ Lachnospira Brush sample ‎Human [1.5]

‐ Lactobacillales Faeces ‎Human [1.23]

‐ Lactobacillus Tissue biopsie ‎Human [1.8]

‐ Lactobacillus Brush sample ‎Human [1.5]

‐ Microviridae Tissue biopsie ‎Human [1.24]

‐ Mitsuokella Faeces ‎Human [1.4]

‐ Myoviridae Tissue biopsie ‎Human [1.24]

‐ Orthopneumovirus Tissue biopsie ‎Human [1.24]

‐ Paracoccus Brush sample ‎Human [1.5, 1.5]

‐ Parvimonas Faeces ‎Human [1.4]

‐ Peptostreptococcaceae Tissue biopsie ‎Human [1.2]

‐ Pneumoviridae Tissue biopsie ‎Human [1.24]

‐ Podoviridae Tissue biopsie ‎Human [1.24]

‐ Prevotella Tissue biopsie ‎Human [1.10]

‐ Prevotella Saliva ‎Human [1.25]

‐ Roseburia Brush sample ‎Human [1.5]

‐ Rothia Faeces ‎Human [1.4]

‐ Ruminococcaceae Tissue biopsie ‎Human [1.2]

‐ Ruminococcus Brush sample ‎Human [1.5]

‐ Ruminococcus gnavus Faeces ‎Human [1.4, 1.16]

‐ Ruminococcus gnavus Tissue biopsie ‎Human [1.26]

‐ Ruminococcus gnavus Brush sample ‎Human [1.5]

‐ Ruminococcus torques Tissue biopsie ‎Human [1.26]

‐ Shigella Faeces ‎Human [1.4, 1.7]

‐ Spirochaetes Tongue scrape sample ‎Human [1.11]

‐ Staphylococcus aureus Subgingival plaque ‎Human [1.27]

‐ Streptococcus Faeces ‎Human [1.1]

‐ Sutterella Faeces ‎Human [1.4]

‐ Sutterella wadsworthensis Faeces ‎Human [1.14]

‐ Synergistetes Tongue scrape sample ‎Human [1.11]

‐ Tissierellaceae Tissue biopsie ‎Human [1.13]

‐ Turicibacter Faeces ‎Human [1.4]

‐ Tyzzerella Faeces ‎Human [1.4]

‐ Veillonella Brush sample ‎Human [1.5]

‐ Veillonella Saliva ‎Human [1.25]

‐ Wallemia Faeces ‎Human [1.18]

Decreased abundance of

‐ Adlercreutzia equolifaciens Faeces ‎Human [1.19]

‐ Akkermansia muciniphila Faeces ‎Human [1.19, 1.28]

‐ Akkermansia muciniphila Tissue biopsie ‎Human [1.26]

‐ Akkermansiaceae Tissue biopsie ‎Human [1.2]

‐ Alistipes Brush sample ‎Human [1.5]

‐ Alistipes shahii Faeces ‎Human [1.19]

‐ Anaerostipes hadrus Tissue biopsie ‎Human [1.29]

‐ Anelloviridae Tissue biopsie ‎Human [1.24]

‐ Asteroleplasma Brush sample ‎Human [1.5]

‐ Asteroleplasma Faeces ‎Human [1.30]

‐ Bacteroidaceae Tissue biopsie ‎Human [1.2]

‐ Bacteroides Faeces ‎Human [1.23]

‐ Bacteroides fragilis Faeces ‎Human [1.31]

‐ Bacteroides massiliensis Faeces ‎Human [1.19]

‐ Bifidobacterium Faeces ‎Human [1.32, 1.33, 1.33]

‐ Bilophila Brush sample ‎Human [1.5]

‐ Bilophila Tissue biopsie ‎Human [1.13]

‐ Bilophila wadsworthia Faeces ‎Human [1.16]

‐ Blautia Faeces ‎Human [1.31]

‐ Blautia coccoides Faeces ‎Human [1.32, 1.34]

‐ Brachyspira Brush sample ‎Human [1.5]

‐ Butyricicoccus pullicaecorum Faeces ‎Human [1.28]

‐ Butyricimonas Brush sample ‎Human [1.5]

‐ Butyricimonas Tissue biopsie ‎Human [1.13]

‐ Catenibacterium Faeces ‎Human [1.30]

‐ Christensenella Brush sample ‎Human [1.5]

‐ Christensenellaceae Faeces ‎Human [1.4]

‐ Cloacibacillus Brush sample ‎Human [1.5]

‐ Clostridioides difficile Faeces ‎Human [1.9]

‐ Clostridium cellulovorans Faeces ‎Human [1.19]

‐ Clostridium cluster IV Faeces ‎Human [1.23]

‐ Clostridium cluster XIVa Faeces ‎Human [1.31]

‐ Clostridium coccoides group Tissue biopsie ‎Human [1.10]

‐ Clostridium colinum Faeces ‎Human [1.28]

‐ Clostridium hathewayi Faeces ‎Human [1.31]

‐ Clostridium leptum Faeces ‎Human [1.31, 1.32, 1.35]

‐ Clostridium oroticum Faeces ‎Human [1.31]

‐ Coccolithovirus Tissue biopsie ‎Human [1.24]

‐ Collinsella aerofaciens Faeces ‎Human [1.19]

‐ Coprobacter fastidiosus Faeces ‎Human [1.19]

‐ Coprococcus Brush sample ‎Human [1.5]

‐ Coprococcus Faeces ‎Human [1.7]

‐ Coprococcus catus Faeces ‎Human [1.28]

‐ Coriobacteriaceae Faeces ‎Human [1.33]

‐ Defluviitalea Brush sample ‎Human [1.5]

‐ Desulfovibrio Brush sample ‎Human [1.5]

‐ Desulfovibrio Tissue biopsie ‎Human [1.13]

‐ Dialister Faeces ‎Human [1.9]

‐ Dorea formicigenerans Faeces ‎Human [1.31]

‐ Enterococcus Brush sample ‎Human [1.5]

‐ Eubacterium Tissue biopsie ‎Human [1.13]

‐ Eubacterium rectale Tissue biopsie ‎Human [1.10]

‐ Eubacterium rectale Faeces ‎Human [1.16]

‐ Faecalibacterium prausnitzii Faeces ‎Human [1.12, 1.16, 1.28, 1.32, 1.35]

‐ Fusicatenibacter saccharivorans Faeces ‎Human [1.31]

‐ Fusobacteria Tongue scrape sample ‎Human [1.11]

‐ Gemmiger Faeces ‎Human [1.1]

‐ Gemmiger Brush sample ‎Human [1.5]

‐ Gemmiger Tissue biopsie ‎Human [1.29]

‐ Gemmiger formicilis Faeces ‎Human [1.19]

‐ Haemophilus Saliva ‎Human [1.25]

‐ Hanseniaspora Faeces ‎Human [1.18]

‐ Helicobacter Brush sample ‎Human [1.5]

‐ Hypsizygus Faeces ‎Human [1.18]

‐ Issatchenkia Faeces ‎Human [1.18]

‐ Lachnobacterium Brush sample ‎Human [1.5]

‐ Lachnospira Faeces ‎Human [1.1]

‐ Lachnospiraceae Tissue biopsie ‎Human [1.29]

‐ Lachnospiraceae Faeces ‎Human [1.33]

‐ Lactobacillus Faeces ‎Human [1.33]

‐ Leptotrichia Tissue biopsie ‎Human [1.13]

‐ Leuconostocaceae Faeces ‎Human [1.15]

‐ Leucosporidium Faeces ‎Human [1.18]

‐ Methanobrevibacter Brush sample ‎Human [1.5]

‐ Mimivirus Tissue biopsie ‎Human [1.24]

‐ Mogibacterium Brush sample ‎Human [1.5]

‐ Naganishia Faeces ‎Human [1.18]

‐ Neisseria Tissue biopsie ‎Human [1.13, 1.13]

‐ Odoribacter Brush sample ‎Human [1.5]

‐ Odoribacter splanchnicus Faeces ‎Human [1.19]

‐ Orthopoxvirus Tissue biopsie ‎Human [1.24]

‐ Oscillospira Brush sample ‎Human [1.5]

‐ Oxalobacter Brush sample ‎Human [1.5]

‐ Parvimonas micra Subgingival plaque ‎Human [1.27]

‐ Peptococcus Brush sample ‎Human [1.5]

‐ Peptostreptococcus anaerobius Subgingival plaque ‎Human [1.27]

‐ Phascolarctobacterium Faeces ‎Human [1.15, 1.28]

‐ Phascolarctobacterium Brush sample ‎Human [1.5]

‐ Polydnaviridae Tissue biopsie ‎Human [1.22]

‐ Prevotella Tissue biopsie ‎Human [1.13]

‐ Prevotella Faeces ‎Human [1.30]

‐ Prevotella Brush sample ‎Human [1.5]

‐ Pseudomonas Brush sample ‎Human [1.5]

‐ Pseudoxanthomonas Brush sample ‎Human [1.5]

‐ Rikenellaceae Brush sample ‎Human [1.5]

‐ Roseburia Faeces ‎Human [1.9, 1.15, 1.28]

‐ Roseburia hominis Faeces ‎Human [1.12]

‐ Ruminococcus bromii Faeces ‎Human [1.19]

‐ Ruminococcus bromii Brush sample ‎Human [1.5]

‐ Ruminococcus gnavus Faeces ‎Human [1.28, 1.31]

‐ Sporobacter Faeces ‎Human [1.1]

‐ Streptococcus Faeces ‎Human [1.30]

‐ Streptococcus Saliva ‎Human [1.36]

‐ Streptococcus anginosus Subgingival plaque ‎Human [1.27]

‐ Streptococcus mitis Subgingival plaque ‎Human [1.27]

‐ Synergistes Brush sample ‎Human [1.5]

‐ Thermicanus Brush sample ‎Human [1.5]

‐ Turicibacter sanguinis Faeces ‎Human [1.19]

‐ Tymoviridae Tissue biopsie ‎Human [1.22]

‐ Vivictivallis Brush sample ‎Human [1.5]

Ulcerative Colitis {40000109}

Record Keys

Details

Links

Meta Information

Notes

Shared Notes

Common References