Ulcerative Colitis {40000109}
Definition: | Ulcerative Colitis |
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Class: | [ ] |
Other Terms: | [ ] |
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Authoring date: | 2020-09-06 |
ICD: | [ ] |
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Category: | Gastroenterologic, Rheumatologic |
MedDra ID: | 10009900 |
MedDra Level: | pt |
Notes
[ ]
Shared Notes
- [1.37]
- Significantly higher abundances of Bifidobacterium in UC. - [1.38]
- A positive association between a “high sugar and soft drinks” pattern and UC risk
- When considering the foods most associated with the pattern, high consumers of sugar and soft drinks were at higher UC risk only if they had low vegetables intakes. - [1.3]
- Functional analysis revealed increased fecal proteolytic and elastase activity before UC onset.
- Elastase activity inversely correlated with the relative abundance of Adlercreutzia.
- Elastase activity directly correlated with known proteolytic taxa, such as Bacteroides vulgatus and high elastase activity was confirmed in Bacteroides isolates from fecal samples.
- Mice colonized with or born from pre-UC colonized dams developed higher fecal proteolytic activity and an inflammatory immune tone compared with HC colonized mice. - [1.39]
- The safety and tolerability of SER-287 were similar to placebo.
- SER-287 after vancomycin was significantly more effective than placebo for induction of remission in patients with active mild to moderate UC.
Common References
- [1.1] A comparative study of the gut microbiota in immune-mediated inflammatory diseases - does a common dysbiosis exist? [2018] [80000942] [Microbiome]
- [1.2] Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers [2015] [80000658] [Gut]
- [1.3] Novel fecal biomarkers that precede clinical diagnosis of ulcerative colitis. [2021] [Research] [80001572] [Gastroenterology]
- [1.4] Combined signature of the fecal microbiome and plasma metabolome in patients with ulcerative colitis [2019] [80001189] [Medical Science Monitor]
- [1.5] Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease [2018] [80000679] [Journal of Gastroenterology]
- [1.6] Disease-specific alterations in the enteric virome in inflammatory Bowel disease [2015] [Research] [80001194] [Cell]
- [1.7] Characteristics of fecal and mucosa-associated microbiota in Chinese patients with inflammatory bowel disease [2014] [80000665] [Medicine]
- [1.8] Alterations of mucosal microbiota in the colon of patients with inflammatory bowel disease revealed by real time polymerase chain reaction amplification of 16S ribosomal ribonucleic acid. [2015] [80000597] [Indian J Med Res]
- [1.9] Gut microbiota dysbiosis in children with relapsing idiopathic nephrotic syndrome [2018] [80000692] [American Journal of Nephrology]
- [1.10] Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease [2005] [80000610] [Journal of Clinical Microbiology]
- [1.11] Alterations in diversity of the oral microbiome in pediatric inflammatory bowel disease [2012] [80000404] [Inflammatory Bowel Diseases]
- [1.12] A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis [2014] [80000592] [Gut]
- [1.13] Comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis [2018] [80000716] [Journal of Gastroenterology and Hepatology]
- [1.14] Fecal microbiota in pediatric inflammatory bowel disease and its relation to inflammation [2015] [80000523] [The American Journal of Gastroenterology]
- [1.15] Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment [2012] [80000991] [Genome Biology]
- [1.16] Gut microbiota differs between children with inflammatory bowel disease and healthy siblings in taxonomic and functional composition: a metagenomic analysis [2017] [80000660] [American journal of physiology. Gastrointestinal and liver physiology]
- [1.17] Desulfovibrio bacterial species are increased in ulcerative colitis [2010] [80000288] [Diseases of the Colon & Rectum]
- [1.18] Characterization of fungal dysbiosis in Japanese patients with inflammatory bowel disease [2019] [80000995] [Journal of Gastroenterology]
- [1.19] The microbiome reflects diagnosis and predicts disease severity in paediatric onset inflammatory bowel disease [2019] [80001185] [Scandinavian Journal of Gastroenterology]
- [1.20] Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody. [2002] [80000287] [Journal of Gastroenterology and Hepatology]
- [1.21] Increased Gardnerella vaginalis urogenital biofilm in inflammatory bowel disease [2014] [80000633] [Journal of Crohn's and Colitis]
- [1.22] Metagenomic analysis of intestinal mucosa revealed a specific eukaryotic gut virome signature in early-diagnosed inflammatory bowel disease [2018] [80000803] [Gut microbes]
- [1.23] Terminal Restriction Fragment length Polymorphism Analysis of the Gut Microbiota Profiles of Pediatric Patients with Inflammatory Bowel Disease [2012] [80000619] [Digestion]
- [1.24] Gut mucosal virome alterations in ulcerative colitis [2019] [80000989] [Gut]
- [1.25] Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers [2014] [80000489] [DNA Research]
- [1.26] Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria [2010] [80000253] [The American Journal of Gastroenterology]
- [1.27] Subgingival microflora in inflammatory bowel disease patients with untreated periodontitis. [2013] [80000235] [European Journal of Periodontology & Hepatology]
- [1.28] Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis [2017] [80000752] [World journal of gastroenterology]
- [1.29] Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease [2020] [80001325] [Nature communications]
- [1.30] A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes [2010] [80000284] [Gastroenterology]
- [1.31] A single species of Clostridium subcluster XIVa decreased in ulcerative colitits patients [2016] [80000620] [Inflammatory Bowel Diseases]
- [1.32] Low counts of faecalibacterium prausnitzii in Colitis microbiota [2009] [80000286] [Inflammatory Bowel Diseases]
- [1.33] Altered fecal microbiota in paediatric inflammatory bowel disease [2015] [80000564] [Journal of Crohn's and Colitis]
- [1.34] Specificities of the fecal microbiota in inflammatory bowel disease [2006] [80000283] [Inflammatory Bowel Diseases]
- [1.35] Clostridium leptum group bacteria abundance and diversity in the fecal microbiota of patients with inflammatory bowel disease: a case-control study in India [2013] [80000611] [BMC Gastroenterology]
- [1.36] Dysbiosis of the salivary microbiota in pediatric-onset primary sclerosing cholangitis and its potential as a biomarker [2018] [80000746] [Scientific Reports]
- [1.37] A comparative study of the gut microbiota in immune-mediated inflammatory diseases—does a common dysbiosis exist? [2018] [Research] [80000038] [Microbiome]
- [1.38] Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe: Results from the EPIC Study [2015] [Research] [80001533] [Inflammatory Bowel Diseases]
- [1.39] A Phase 1b Safety Study of SER-287, a Spore-Based Microbiome Therapeutic, for Active Mild to Moderate Ulcerative Colitis [2021] [Research] [80001603] [Gastroenterology]