Microbiome & Chronic Diseases

Evidence Based Medicine
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Ulcerative Colitis {40000109}

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Ulcerative Colitis
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ICD:[  ]
Gastroenterology, Rheumatology
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Shared Notes

  • [1.37
    - A positive association between a “high sugar and soft drinks” pattern and UC risk
    - When considering the foods most associated with the pattern, high consumers of sugar and soft drinks were at higher UC risk only if they had low vegetables intakes.
  • [1.3
    - Functional analysis revealed increased fecal proteolytic and elastase activity before UC onset.
    - Elastase activity inversely correlated with the relative abundance of Adlercreutzia.
    - Elastase activity directly correlated with known proteolytic taxa, such as Bacteroides vulgatus and high elastase activity was confirmed in Bacteroides isolates from fecal samples.
    - Mice colonized with or born from pre-UC colonized dams developed higher fecal proteolytic activity and an inflammatory immune tone compared with HC colonized mice.
  • [1.38
    - Significantly higher abundances of Bifidobacterium in UC.
  • [1.39
    - The safety and tolerability of SER-287 were similar to placebo.
    - SER-287 after vancomycin was significantly more effective than placebo for induction of remission in patients with active mild to moderate UC.
  • [1.36
    - Red meat is metabolized by intestinal bacteria with production of branched-chain amino acids and toxic elements like hydrogen sulfide, nitrous compounds, amines, and ammonia that induce DNA damage of eucaryotic cells and promote colon inflammation in murine models.
    - Large epidemiological data confirmed the association between high consumption of red meat and risk of IBD development, in particular UC , where it was found to affect also the relapse risk.
  • [1.40
    - Intestinal microbiota in UC is associated with abundant small atypical N-glycans.
    - Higher level of microbiota-associated atypical N-glycans in UC than controls.
    - Atypical N-glycans act as promising biomarker candidates for pediatric UC.
  • [1.41
    - in patients suffering from ulcerative colitis (UC), P-gp expression coupled to the reduction of epithelial-derived anti-inflammatory endocannabinoids and luminal content (e.g., microbes or their metabolites) with a reduced capability to induce P-gp expression.
  • [1.43
    - Two commonly used emulsifiers, carboxymethylcellulose and polysorbate-80 > induce inflammation and metabolic changes, mediated by gut microbes.

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