Esophageal cancer ⇒ Cancer {40000175}
| Definition: | Esophageal cancer |
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| Class: |
| Other Terms: | [ ] |
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| Authoring date: | 2020-09-01 |
| ICD: | [ ] |
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| Category: | Gastroenterologic, Oncologic |
| MedDra ID: | 10030155 |
| MedDra Level: | pt |
Notes
- P. gingivalis was detected immunohistochemically in 61 % of cancerous tissues, 12 % of adjacent tissues and was undetected in normal esophageal mucosa. A similar distribution of lysine-specific gingipain, a catalytic endoprotease uniquely secreted by P. gingivalis, and P. gingivalis 16S rDNA was also observed.
- P. gingivalis infection positively associated with multiple clinicopathologic characteristics, including differentiation status, metastasis, and overall survival rate. (1)
Shared Notes
- [1.3]
- The presence of oral P. gingivalis and T. forsythia associate with an increased risk of esophageal cancer.
- P. gingivalis and T. forsythia are included in signaling pathways responsible for cancer development.
- T. forsythia may induce pro-inflammatory cytokines such as IL-1β and IL-6 by CD4 + T helper cells and TNF-α.
- gingipain K produced by P. gingivalis, affects hosts immune system by degradation of immunoglobulins and complement system.
Common References
- [1.1] Alterations to the esophageal microbiome associated with progression from barrett's esophagus to esophageal adenocarcinoma [2019] [80001087] [Cancer Epidemiology, Biomarkers & Prevention]
- [1.2] Human Microbiome Fusobacterium Nucleatum in Esophageal Cancer Tissue Is Associated with Prognosis [2016] [80000292] [Clinical cancer research]
- [1.3] The role of Tannerella forsythia and Porphyromonas gingivalis in pathogenesis of esophageal cancer [2019] [Research] [80000148] [Infectious Agents and Cancer]