Amyotrophic lateral sclerosis {40000171}
| Definition: | Amyotrophic lateral sclerosis |
|---|---|
| Class: | [ ] |
| Other Terms: | ALS |
|---|---|
| Authoring date: | 2019-08-25 |
| ICD: | [ ] |
|---|---|
| Category: | Neurologic |
| MedDra ID: | 10002026 |
| MedDra Level: | pt |
Notes
[ ]
Shared Notes
- [1.6]
- Nicotinamide produced by the Akkermansia muciniphila bacteria slowed disease progression and prolonged survival in an ALS mouse model.
- Nicotinamide benefits may be linked with improvements in mitochondria function.
- Nicotinamide and its intermediary molecules significantly reduced in ALS.
- Nicotinamide levels were decreased in the brains of ALS patients; this reduction was associated with enhanced muscle weakness.
- Ruminococcus torques and Parabacteroides distasonis worsened ALS symptoms (1)
Common References
- [1.1] Evaluation of the microbial diversity in amyotrophic lateral sclerosis using high-throughput sequencing [2016] [80001142] [Frontiers in Microbiology]
- [1.2] The alteration of gut microbiome and metabolism in amyotrophic lateral sclerosis patients [2020] [80001425] [Scientific Reports]
- [1.3] Gut inflammation and dysbiosis in human motor neuron disease [2017] [80000667] [Pysiological Reports]
- [1.4] Potential role of gut microbiota in ALS pathogenesis and possible novel therapeutic strategies [2018] [80000818] [Journal of Clinical Gastroenterology]
- [1.5] Intestinal microbiota composition in patients with amyotrophic lateral sclerosis: establishment of bacterial and archaeal communities analyses [2019] [80001111] [Chinese Medical Journal]
- [1.6] Potential roles of gut microbiome and metabolites in modulating ALS in mice [2019] [Abstract] [80000103] [Nature]