MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Amyotrophic lateral sclerosis {40000171}

Record Keys
Definition:
Amyotrophic lateral sclerosis
Class:[  ]

Details
Other Terms:
ALS
Initialisation date:
2019-08-25

Links

Meta Information
ICD:[  ]
Category:
Neurology
MedDra ID:
10002026
MedDra Level:
pt

Notes

[  ]

Shared Notes

  • [1.7] 
    - Nicotinamide produced by the Akkermansia muciniphila bacteria slowed disease progression and prolonged survival in an ALS mouse model.
    - Nicotinamide benefits may be linked with improvements in mitochondria function.
    - Nicotinamide and its intermediary molecules significantly reduced in ALS.
    - Nicotinamide levels were decreased in the brains of ALS patients; this reduction was associated with enhanced muscle weakness.
    - Ruminococcus torques and Parabacteroides distasonis worsened ALS symptoms (1)
  • [1.8] 
    - IL-8, IL-15, MCP-1 and VEGF-A levels were significantly lower in patients than controls, while others did not show a different distribution among groups.
    - IP-10 levels were positively correlated with survival.
  • - The fecal SCFA concentrations (µmol/g) were not significantly different between ALS patients and controls, or between patients with different clinical characteristics.
  • [1.6] 
    - Greater abundance of Ruminococcus, at genus level > related to higher risk of ALS.
    - Kynurenine > risk factor of ALS.

Common References