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Amyotrophic lateral sclerosis {40000171}

Record Keys


Definition:
Amyotrophic lateral sclerosis
Class:[  ]

Details


Other Terms:
ALS
Initialisation date:
2019-08-25

Links


Meta Information


ICD:[  ]
Category:
Neurology
MedDra ID:
10002026
MedDra Level:
pt

Notes


[  ]

Shared Notes


  • [1.7
    - Nicotinamide produced by the Akkermansia muciniphila bacteria slowed disease progression and prolonged survival in an ALS mouse model.
    - Nicotinamide benefits may be linked with improvements in mitochondria function.
    - Nicotinamide and its intermediary molecules significantly reduced in ALS.
    - Nicotinamide levels were decreased in the brains of ALS patients; this reduction was associated with enhanced muscle weakness.
    - Ruminococcus torques and Parabacteroides distasonis worsened ALS symptoms (1)
  • [1.8
    - IL-8, IL-15, MCP-1 and VEGF-A levels were significantly lower in patients than controls, while others did not show a different distribution among groups.
    - IP-10 levels were positively correlated with survival.
  • - The fecal SCFA concentrations (µmol/g) were not significantly different between ALS patients and controls, or between patients with different clinical characteristics.
  • [1.6
    - Greater abundance of Ruminococcus, at genus level > related to higher risk of ALS.
    - Kynurenine > risk factor of ALS.
  • [1.10
    - In spinal motor neurons human induced pluripotent stem cell lines > elevated levels of arachidonic acid.
    - Pharmacological reduction of arachidonic acid levels > reverse ALS-related phenotypes in both human sMNs and in vivo in Drosophila and SOD1G93A mouse models.


[Coverage other Diseases (Overlap > 0.25)]

DiseaseOverlapCommon increased OrganismCommon decreased Organism
Amyotrophic lateral sclerosis 1.0000 19 (100%) : Akkermansia muciniphila | Anaerostipes | Anaerotruncus | Bacteroides vulgatus | Clostridiales | Eisenbergiella | Escherichia coli | Kineothrix | Lachnospiraceae | Mannheimia | Methanobrevibacter | Odoribacter | Oscillibacter | Parabacteroides | Parabacteroides distasonis | Porphyromonadaceae | Ruminococcus | Ruminococcus torques | Sporobacter 6 (100%) : Bacteroides | Clostridium | Dorea | Faecalibacterium | Megamonas | Ruminococcus
Crohn's disease 0.6535 9 (47%) : Anaerostipes | Anaerotruncus | Bacteroides vulgatus | Escherichia coli | Lachnospiraceae | Odoribacter | Parabacteroides distasonis | Ruminococcus | Ruminococcus torques 5 (83%) : Bacteroides | Clostridium | Dorea | Faecalibacterium | Ruminococcus
Chronic kidney disease 0.6053 4 (21%) : Anaerotruncus | Escherichia coli | Parabacteroides | Ruminococcus torques 6 (100%) : Bacteroides | Clostridium | Dorea | Faecalibacterium | Megamonas | Ruminococcus
Colorectal cancer 0.5746 6 (32%) : Akkermansia muciniphila | Anaerotruncus | Clostridiales | Escherichia coli | Oscillibacter | Ruminococcus 5 (83%) : Bacteroides | Dorea | Faecalibacterium | Megamonas | Ruminococcus
Parkinson's Disease 0.5702 9 (47%) : Akkermansia muciniphila | Anaerotruncus | Eisenbergiella | Lachnospiraceae | Odoribacter | Parabacteroides | Porphyromonadaceae | Ruminococcus | Ruminococcus torques 4 (67%) : Clostridium | Dorea | Faecalibacterium | Ruminococcus
HIV infection 0.5219 4 (21%) : Anaerotruncus | Eisenbergiella | Oscillibacter | Ruminococcus 5 (83%) : Bacteroides | Clostridium | Dorea | Faecalibacterium | Ruminococcus
Non-alcoholic fatty liver disease 0.4956 3 (16%) : Lachnospiraceae | Oscillibacter | Ruminococcus 5 (83%) : Bacteroides | Clostridium | Dorea | Faecalibacterium | Ruminococcus
Multiple Sclerosis 0.4912 6 (32%) : Akkermansia muciniphila | Anaerotruncus | Methanobrevibacter | Parabacteroides | Ruminococcus | Sporobacter 4 (67%) : Bacteroides | Clostridium | Dorea | Faecalibacterium
Sjögren syndrome 0.4430 1 (5%) : Bacteroides vulgatus 5 (83%) : Bacteroides | Clostridium | Dorea | Faecalibacterium | Ruminococcus
Obesity 0.4386 4 (21%) : Bacteroides vulgatus | Methanobrevibacter | Parabacteroides | Ruminococcus torques 4 (67%) : Bacteroides | Faecalibacterium | Megamonas | Ruminococcus
Major depressive disorder 0.4123 3 (16%) : Anaerostipes | Oscillibacter | Parabacteroides 4 (67%) : Bacteroides | Clostridium | Faecalibacterium | Ruminococcus
Type 2 diabetes 0.4079 6 (32%) : Akkermansia muciniphila | Escherichia coli | Lachnospiraceae | Methanobrevibacter | Parabacteroides | Parabacteroides distasonis 3 (50%) : Dorea | Faecalibacterium | Megamonas
Cirrhosis 0.3816 5 (26%) : Bacteroides vulgatus | Escherichia coli | Parabacteroides | Porphyromonadaceae | Ruminococcus 3 (50%) : Bacteroides | Dorea | Ruminococcus
Uveitits 0.3333 0 (0%) 4 (67%) : Bacteroides | Dorea | Faecalibacterium | Ruminococcus
Keratitis 0.3333 0 (0%) 4 (67%) : Clostridium | Dorea | Faecalibacterium | Ruminococcus
Irritable bowel syndrome 0.3289 3 (16%) : Escherichia coli | Odoribacter | Sporobacter 3 (50%) : Bacteroides | Dorea | Faecalibacterium
Kidney stone 0.3289 3 (16%) : Lachnospiraceae | Parabacteroides | Parabacteroides distasonis 3 (50%) : Dorea | Faecalibacterium | Ruminococcus
Alcoholism 0.3289 3 (16%) : Lachnospiraceae | Odoribacter | Parabacteroides 3 (50%) : Dorea | Faecalibacterium | Ruminococcus
Schizophrenia 0.3246 6 (32%) : Akkermansia muciniphila | Anaerotruncus | Eisenbergiella | Methanobrevibacter | Oscillibacter | Porphyromonadaceae 2 (33%) : Clostridium | Faecalibacterium
Inflamatory bowel disease 0.3026 2 (11%) : Bacteroides vulgatus | Ruminococcus torques 3 (50%) : Bacteroides | Faecalibacterium | Ruminococcus
Coronary artery disease 0.3026 2 (11%) : Odoribacter | Parabacteroides distasonis 3 (50%) : Bacteroides | Dorea | Faecalibacterium
Ankylosing spondylitis 0.2982 5 (26%) : Escherichia coli | Lachnospiraceae | Oscillibacter | Parabacteroides distasonis | Porphyromonadaceae 2 (33%) : Clostridium | Ruminococcus
Autism 0.2939 8 (42%) : Akkermansia muciniphila | Bacteroides vulgatus | Lachnospiraceae | Odoribacter | Parabacteroides | Parabacteroides distasonis | Ruminococcus | Ruminococcus torques 1 (17%) : Bacteroides
Alzheimer's disease 0.2763 1 (5%) : Bacteroides vulgatus 3 (50%) : Bacteroides | Clostridium | Ruminococcus
Hypertension 0.2763 1 (5%) : Parabacteroides 3 (50%) : Clostridium | Dorea | Faecalibacterium
Pancreatic Cancer 0.2763 1 (5%) : Lachnospiraceae 3 (50%) : Dorea | Faecalibacterium | Megamonas
Acquired Immunodeficiency Syndrome 0.2763 1 (5%) : Ruminococcus 3 (50%) : Faecalibacterium | Megamonas | Ruminococcus
Chronic pancreatitis 0.2763 1 (5%) : Parabacteroides 3 (50%) : Dorea | Faecalibacterium | Megamonas
Type 1 diabetes 0.2719 4 (21%) : Bacteroides vulgatus | Clostridiales | Escherichia coli | Ruminococcus 2 (33%) : Faecalibacterium | Megamonas
Psoriasis 0.2719 4 (21%) : Bacteroides vulgatus | Lachnospiraceae | Parabacteroides | Ruminococcus 2 (33%) : Bacteroides | Faecalibacterium
Clostridium difficile infection 0.2719 4 (21%) : Akkermansia muciniphila | Escherichia coli | Parabacteroides | Ruminococcus 2 (33%) : Bacteroides | Faecalibacterium
Asthma 0.2675 7 (37%) : Anaerostipes | Eisenbergiella | Escherichia coli | Odoribacter | Oscillibacter | Parabacteroides | Ruminococcus 1 (17%) : Faecalibacterium

[Coverage Factors (Overlap > 0.10)]

FactorOverlapCommon increased OrganismCommon decreased Organism
Chemotherapy treatment 0.1667 0 (0%) 2 (33%) : Bacteroides | Clostridium
Oral administration of Metformin 0.1623 3 (16%) : Akkermansia muciniphila | Clostridiales | Ruminococcus 1 (17%) : Dorea
High Socio-economic status 0.1360 2 (11%) : Anaerostipes | Lachnospiraceae 1 (17%) : Bacteroides

Common References