MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Polycystic ovary syndrome {40000170}

Record Keys
Definition:
Polycystic ovary syndrome
Class:[  ]

Details
Other Terms:
PCOS
Authoring date:
2019-08-18

Links

Meta Information
ICD:[  ]
Category:
Endocrinologic, Gyneocologic
MedDra ID:
10036049
MedDra Level:
pt

Notes

- Women with PCOS has a homogenous gut microbiome and an enrichment in Bacteroides vulgatus, along with an increase in genes that encode bile salt hydrolases.
- Stool transplantation from women with PCOS or the administration of B. vulgatus by oral gavage induced insulin resistance, a disrupted estrous cycle and ovarian morphology, altered bile acid metabolism, reduced interleukin-22 secretion and infertility and changes in testosterone and luteinizing hormone levels in recipient mice.
- Decrease in glycodeoxycholic acid and subsequent decreased IL-22 also documented in women with PCOS. glycodeoxycholic acid induced intestinal group 3 innate lymphoid cell IL-22 secretion through GATA binding protein 3, and IL-22 in turn improved the PCOS phenotype. This finding is consistent with the reduced levels of IL-22 in individuals with PCOS. (1)

Shared Notes

  • [1.7] 
    - A dysbiotic gut microbiome from women with PCOS or Bacteroides vulgatus (positively associated with PCOS in antibiotic-treated mice) transplanted into mice induced a PCOS-like phenotype (HA, disrupted estrous cycle, decreased ovulation, ovarian cysts, and a decrease in fertility.)
    - Higher testosterone levels are linked with changes in the overall composition of the gut microbial community. It is unclear whether testosterone exerts an effect on gut microbes directly and/or indirectly through actions in androgen target tissues.
  • - Resistant dextrin when given to women with PCOS and women without the disorder for three months lowered levels of free testosterone, hirsutism, the interval between menstrual cycles, fasting blood glucose, and lipid profile in group with PCOS
  • - Inulin improve gut dysbiosis, lower testosterone, and increase estradiol levels while improving ovarian morphology and weight gain in mice fed a high-fat diet
  • - A strain of Bifidobacterium lactis given as a 10-week treatment for PCOS in 14 women with the disorder decreased luteinizing hormone and increased intestinal short-chain fatty acids in a new study
  • - Lactobacillus given to letrozole-treated (induces PCOS) rats reduced androgen levels, improved estrous cyclicity, normalized ovarian morphology, as well as increased Lactobacillus and Clostridium species and decreased Prevotella.

Common References