Polycystic ovary syndrome {40000170}
| Definition: | Polycystic ovary syndrome |
|---|---|
| Class: | [ ] |
| Other Terms: | PCOS |
|---|---|
| Authoring date: | 2019-08-18 |
| ICD: | [ ] |
|---|---|
| Category: | Endocrinologic, Gyneocologic |
| MedDra ID: | 10036049 |
| MedDra Level: | pt |
Notes
- Women with PCOS has a homogenous gut microbiome and an enrichment in Bacteroides vulgatus, along with an increase in genes that encode bile salt hydrolases.
- Stool transplantation from women with PCOS or the administration of B. vulgatus by oral gavage induced insulin resistance, a disrupted estrous cycle and ovarian morphology, altered bile acid metabolism, reduced interleukin-22 secretion and infertility and changes in testosterone and luteinizing hormone levels in recipient mice.
- Decrease in glycodeoxycholic acid and subsequent decreased IL-22 also documented in women with PCOS. glycodeoxycholic acid induced intestinal group 3 innate lymphoid cell IL-22 secretion through GATA binding protein 3, and IL-22 in turn improved the PCOS phenotype. This finding is consistent with the reduced levels of IL-22 in individuals with PCOS. (1)
Common References
- [1.1] Structural and functional profiles of the gut microbial community in polycystic ovary syndrome with insulin resistance (IR-PCOS): a pilot study [2019] [80000919] [Research in Microbiology]
- [1.2] Obese adolescents with PCOS have altered biodiversity and relative abundance in Gastrointestinal microbiota [2020] [80001360] [The Journal of Clinical Endocrinology and Metabolism]
- [1.3] Characteristic gut microbiota and predicted metabolic functions in women with PCOS [2020] [80001274] [Endocrine Connections]
- [1.4] The Salivary Microbiome in Polycystic Ovary Syndrome (PCOS) and Its Association with Disease-Related Parameters: A Pilot Study [2016] [80000403] [Frontiers in Microbiology]
- [1.5] Dysbiosis of gut microbiota associated with clinical parameters in polycistic ovary syndrome [2017] [80000443] [Frontiers in Microbiology]
- [1.6] Alterations in gut microbiome composition and barrier function are associated with reproductive and metabolic defects in women with polycystic ovary syndrome (PCOS): a pilot study. [2017] [80000450] [PLOS ONE]