MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Obesity {40000167}

Record Keys


Definition:
Obesity
Class:[  ]

Details


Other Terms:[  ]
Initialisation date:
2019-06-23

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Meta Information


ICD:[  ]
Category:
Gastroenterology, Endocrinology, Metabolomics
MedDra ID:
10029883
MedDra Level:
pt

Notes


[  ]

Shared Notes


  • [1.40
    - Early antibiotic exposure in animal models has shown that reductions in the population size of specific microbiota, such as Lactobacillus, Allobaculum, Rikenellaceae, and Candidatus Arthromitus, are related to subsequent adiposity.
  • [1.19
    - The probiotic strain Hafnia alvei HA4597® (HA), which produces the satietogenic peptide ClpB mimicking the effect of alpha-MSH, reduced weight gain and adiposity in rodent models of obesity.
  • [1.41
    - Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas, a biomarker of the overweight/obese group.
  • - Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers.
  • [1.44
    - Bacteroidetes > prevalence is lower in obese people > low-calorie diet > proportion increasealong with weight loss based on a low-calorie diet .
  • - SCFAs > activation of their receptors GPR43 and GPR41 > inhibits lipolysis > adipocyte differentiation.
  • - The presence of a dysbiotic microbiome > subsequent increases in gut permeability to bacteria-derived pathogens, including LPS and ethanol.
    - LPS, gut peptides, SCFAs and lactate > Microbiota-brain-gut axis > Gut afferent neuron > key signaling molecules involved in gut-brain communication and host metabolism.

Common References