Disease ⇒ Urinary stone disease {40000161}

References Notes

Shared Reference Notes

• [1.1] 
  - Lactobacillus may inhibit stone growth. However, our multi-omics integration strongly points to three unknown metabolites.
  - The bacterium Oxalobacter formigenes uses oxalate as a carbon and energy source for growth, is negatively associated with both USD and urinary oxalate, is sensitive to common antibiotics, and can reduce urinary oxalate when administered orally as a probiotic, all of which implicates loss of function dysbiosis associated with this species and calcium oxalate stone formation.
• [1.2] 
  - antibiotics cause a rapid loss of gut microbial oxalate metabolism, and while disturbed bacteria can partially recover over time, the ability to metabolize oxalate does not.
  - This results in the accumulation of oxalates in the body and increases the risk of kidney stones.