MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Cognitive impairment {40000159}

Record Keys


Definition:
Cognitive impairment
Class:[  ]

Details


Other Terms:[  ]
Initialisation date:
2021-09-09

Meta Information


ICD:[  ]
Category:
Neurology
MedDra ID:[  ]
MedDra Level:[  ]

Notes


[  ]

Shared Notes


  • [1.1
    - Carbohydrate-restricted (ketogenic) diet potentiates CI induced by intermittent hypoxia in mice and alters the gut microbiota.
    - Depleting the microbiome reduces CI, whereas transplantation of the risk-associated microbiome or monocolonization with Bilophila wadsworthia confers CI in mice fed a standard diet.
    - B. wadsworthia and the risk-associated microbiome disrupt hippocampal synaptic plasticity, neurogenesis, and gene expression.
    - The CI is associated with microbiome-dependent increases in intestinal interferon-gamma (IFNg)-producing Th1 cells. - Inhibiting Th1 cell development abrogates the adverse effects of both B. wadsworthia and environmental risk factors on CI.

Common References