Disease ⇒ Glioblastoma {40000155}

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Shared Reference Notes

  • [1.1] [#Keto diet
    - This is the first report of confirmed IDH1-mutant GBM treated with KMT and surgical debulking without chemo- or radiotherapy. The long-term survival of this patient, now at 80 months, could be due in part to a therapeutic metabolic synergy between KMT and the IDH1 mutation that simultaneously target the glycolysis and glutaminolysis pathways that are essential for GBM growth.
  • [1.2] [#Brain Tumor
    - enriched (Verrucomicrobia and Akkermansia) and depleted taxa (Firmicutes and subsequent Firmicutes/Bacteroides ratio) in both mouse glioma models and glioma patients
  • [1.3
    - QUIN was also shown to enhance glioblastoma cell survival when in excess. - The enhanced cell survival may be due to the excess QUIN increasing the availability of NAD+ when catabolised. This NAD+ is then utilised in DNA repair, essentially reducing the apoptosis that was triggered by chemotherapeutic drugs-

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