Disease ⇒ Glioblastoma {40000155}
| Type: | Disease |
|---|---|
| Definition: | Glioblastoma |
| Parent: | [ ] |
| Initialisation date: | 2021-06-16 |
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| Other Terms: | [ ] |
| MedDra ID: | [ ] |
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| MedDra Level: | [ ] |
| ICD: | [ ] |
| Category: | [ ] |
| Zone: | [ ] |
| Mechanism: | [ ] |
Notes:
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References Notes
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Shared Reference Notes
- [1.1]
- This is the first report of confirmed IDH1-mutant GBM treated with KMT and surgical debulking without chemo- or radiotherapy. The long-term survival of this patient, now at 80 months, could be due in part to a therapeutic metabolic synergy between KMT and the IDH1 mutation that simultaneously target the glycolysis and glutaminolysis pathways that are essential for GBM growth.