Disease ⇒ Skin scar {40000637} Record Keys Type:Disease Parent:[ ] Definition:Skin scar Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - #Resveratrol treatment in human hypertrophic scar-derived fibroblasts (HSFBs) suppressed cell proliferation, which lead to cell cycle arrest and induced apoptosis in a dose- and time-dependent manner. - Treatment with #Resveratrol for 24 hours achieved an antiproliferative effect through an induction of apoptosis. - The effect was enhanced with longer #Resveratrol treatment duration and higher #Resveratrol concentration. - #Resveratrol downregulated Type I and III procollagen mRNA expression in HSFBs, which resulted in a decreased collagen deposition. - As an agonist to SIRT 1, #Resveratrol downregulated mRNA levels of collagen I, collagen III, and α-smooth muscle actin (α-SMA) due to upregulation of SIRT1 in a dose-dependent manner.References Notes[ ]
