Non-alcoholic fatty liver disease ⇒ Steatohepatitis {40000151}

Record Keys
Definition:	Non-alcoholic fatty liver disease
Class:	Steatohepatitis

Details
Other Terms:	NAFLD, NAFLD, Nonalcoholic Steatohepatitis, NASH
Authoring date:	2020-09-06

Links
Wickipedia Merck Manual

Meta Information
ICD:	[ ]
Category:	Gastroenterologic
MedDra ID:	10082249
MedDra Level:	pt

Notes

- Low levels of Parabacteroides distasonis lead to the development of NASH and increase cardiovascular risk. (1)
- Decreased levels of Prevotella might be detrimental for adults with NAFLD. (2)

Shared Notes

[1.17]
- Metagenome-based gut microbiome panel can accurately diagnose advanced fibrosis

Common References

[1.1] Bile acids associate with specific gut microbiota, low-level alcohol consumption and liver fibrosis in patients with non-alcoholic fatty liver disease [2020] [80001417] [Liver International]
[1.2] Microbiome signatures associated with steatohepatitis and moderate to severe fibrosis in children with nonalcoholic fatty liver disease [2019] [80001063] [Gastroenterology]
[1.3] Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease [2015] [80000572] [Scientific Reports]
[1.4] Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach [2017] [80000626] [Hepatology]
[1.5] The severity of Nonalcoholic Fatty Liver Disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota [2016] [80000625] [Hepatology]
[1.6] Fecal and blood microbiota profiles and presences of nonalcoholic fatty liver disease in obese versus lean subjects [2019] [80001021] [PLOS ONE]
[1.7] Changes of intestinal bacterial microbiota in coronary hearth disease complicated with nonalcoholic fatty liver disease [2019] [80001292] [BMC Genomics]
[1.8] Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease [2013] [80001027] [Clinical Gastroenterology and Hepatology]
[1.9] A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease [2019] [80000948] [Nature communications]
[1.10] Metagenome of gut microbiota of children with nonalcoholic fatty liver disease [2019] [80001279] [Frontiers in Pediatrics]
[1.11] Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance [2018] [80000685] [Scientific Reports]
[1.12] Bifidobacteria and lactobacilli in the gut microbiome of children with non-alcoholic fatty liver disease: which strains act as healthy players? [2018] [80000695] [Archives of Medical Science: AMS]
[1.13] An altered fecal microbiota profile in patients with non-alcoholic fatty liver disease (NAFLD) associated with obesity [2019] [80000904] [Revista espanola de enfermedades digestivas]
[1.14] Altered fecal microbiota correlates with liver biochemistry in nonobese patients with non-alcoholic fatty liver disease. [2016] [80000569] [Scientific Reports]
[1.15] Significant decrease in Faecalibacterium among gut microbiota in nonalcoholic fatty liver disease: a large BMI- and sex-matched population study [2019] [80001164] [Hepatology International]
[1.16] A microbial signature identifies advanced fibrosis in patients with chronic liver disease mainly due to NAFLD [2020] [80001341] [Scientific Reports]
[1.17] Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease [2017] [Research] [80001561] [Cell Metabolism]

Increased abundance of

‐ Actinomycetaceae Faeces ‎Human [1.1]
‐ Akkermansia Faeces ‎Human [1.2]
‐ anaerobacter Faeces ‎Human [1.3]
‐ Anaerococcus Faeces ‎Human [1.4]
‐ Bacteroides Faeces ‎Human [1.5]
‐ Bradyrhizobium Faeces ‎Human [1.4]
‐ Caldithrix Blood ‎Human [1.6]
‐ Clostridium group XI Faeces ‎Human [1.3]
‐ Coprococcus Faeces ‎Human [1.7]
‐ Deferribacteriales incertae cedis Blood ‎Human [1.6]
‐ Dorea Faeces ‎Human [1.4, 1.8]
‐ Enterobacteriaceae Faeces ‎Human [1.9]
‐ Enterococcus Faeces ‎Human [1.2]
‐ Escherichia Faeces ‎Human [1.3]
‐ Gallibacterium Faeces ‎Human [1.9]
‐ Klebsiella pneumoniae Faeces ‎Human [1.10]
‐ Kluyvera ascorbata Faeces ‎Human [1.10]
‐ Lachnospiraceae Faeces ‎Human [1.1]
‐ Lactobacillus Faeces ‎Human [1.3, 1.8, 1.11]
‐ Lactobacillus mucosae Faeces ‎Human [1.12]
‐ Lactobacillus ruminis Faeces ‎Human [1.12]
‐ Lactonifactor Faeces ‎Human [1.2]
‐ Oscillibacter Faeces ‎Human [1.2]
‐ Peptoniphilus Faeces ‎Human [1.4]
‐ Phascolarctobacterium succinatutens Faeces ‎Human [1.10]
‐ Propionibacterium acnes Faeces ‎Human [1.4]
‐ Robinsoniella Faeces ‎Human [1.8]
‐ Roseburia Faeces ‎Human [1.8]
‐ Ruminococcus Faeces ‎Human [1.4, 1.5]
‐ Streptococcus Faeces ‎Human [1.3, 1.9, 1.13]
‐ Veillonella Faeces ‎Human [1.7]

Decreased abundance of

‐ Acidaminococcus Faeces ‎Human [1.6]
‐ Alistipes Faeces ‎Human [1.3, 1.11]
‐ Anaerosporobacter Faeces ‎Human [1.14]
‐ Anaerostipes Faeces ‎Human [1.11]
‐ Anaerotruncus Faeces ‎Human [1.14]
‐ Bacillus Faeces ‎Human [1.9]
‐ Bacteroidaceae Faeces ‎Human [1.1]
‐ Bacteroides Faeces ‎Human [1.11]
‐ Bacteroides dorei Faeces ‎Human [1.7]
‐ Bacteroides fragilis Faeces ‎Human [1.7]
‐ Beijerinckiaceae Blood ‎Human [1.6]
‐ Bifidobacterium adolescentis Faeces ‎Human [1.12]
‐ Bifidobacterium bifidum Faeces ‎Human [1.12]
‐ Bifidobacterium longum Faeces ‎Human [1.7, 1.12]
‐ Bilophila Faeces ‎Human [1.6]
‐ Blautia Faeces ‎Human [1.11]
‐ Catenibacterium Faeces ‎Human [1.9]
‐ Citrobacter Faeces ‎Human [1.6]
‐ Clostridium Blood ‎Human [1.6]
‐ Coprococcus Faeces ‎Human [1.11, 1.11, 1.14]
‐ Deinococcus Blood ‎Human [1.6]
‐ Desulfobacteraceae Blood ‎Human [1.6]
‐ Desulfovibrionaceae Faeces ‎Human [1.6]
‐ Dorea Faeces ‎Human [1.11]
‐ Enterobacteriaceae Faeces ‎Human [1.6]
‐ Erysipelothrix Faeces ‎Human [1.6]
‐ Erysipelotrichaceae Faeces ‎Human [1.5]
‐ Faecalibacterium Faeces ‎Human [1.6, 1.11, 1.15]
‐ Faecalibacterium prausnitzii Faeces ‎Human [1.9, 1.11]
‐ Fastidiospila Faeces ‎Human [1.6]
‐ Flavonifractor Faeces ‎Human [1.3]
‐ Lactobacillus Faeces ‎Human [1.10, 1.14]
‐ Lactococcus Faeces ‎Human [1.9]
‐ Leuconostoc Blood ‎Human [1.6]
‐ Mogibacterium Faeces ‎Human [1.9]
‐ Moryella Faeces ‎Human [1.14]
‐ Nocardioides Blood ‎Human [1.6]
‐ Odoribacter Faeces ‎Human [1.3]
‐ Oscillibacter Faeces ‎Human [1.3, 1.8, 1.10, 1.14]
‐ Oscillospira Faeces ‎Human [1.4]
‐ Parabacteroides Faeces ‎Human [1.11]
‐ Parabacteroides distasonis ‎Causal ‎Gut Lumen ‎Human
‐ Parabacteroides johnsonii Faeces ‎Human [1.10]
‐ Parabacteroides merdae Faeces ‎Human [1.7]
‐ Parasutterella Faeces ‎Human [1.6]
‐ Peptostreptococcaceae Faeces ‎Human [1.9]
‐ Prevotella Faeces ‎Human [1.5]
‐ Prevotella copri Faeces ‎Human [1.16]
‐ Prevotella copri ‎Causal ‎Gut Lumen ‎Human
‐ Pseudobutyrivibrio Faeces ‎Human [1.14]
‐ Pseudomonas Faeces ‎Human [1.9]
‐ Rikenellaceae Faeces ‎Human [1.4, 1.9, 1.16]
‐ Roseburia Faeces ‎Human [1.11, 1.14]
‐ Ruminiclostridium Faeces ‎Human [1.10]
‐ Ruminococcaceae Faeces ‎Human [1.16]
‐ Ruminococcus Faeces ‎Human [1.11, 1.11, 1.14]
‐ Ruminococcus gnavus Faeces ‎Human [1.7]
‐ Turicibacter Faeces ‎Human [1.6]

Shared References

Lactobacillus lactis CKDB001 ameliorate progression of nonalcoholic fatty liver disease through of gut microbiome: addendum [Research] [2020] 80001432

References

(1) Effects of Exercise Training on Gut Microbiome in patients with NASH [Report] [2020]
(2) Gut microbiota dysbiosis in patients with non-alcoholic fatty liver disease [Report] [2019]
(3) Microbiome Signatures Associated with Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease [Report] [2019]

Non-alcoholic fatty liver disease ⇒ Steatohepatitis {40000151}

Record Keys

Details

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Notes

Shared Notes

Common References