Microbiome & Chronic Diseases

Evidence Based Medicine
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Immunotherapy-induced colitis {40000144}

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Immunotherapy-induced colitis
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Shared Notes

  • [1.1
    - Dietary prebiotics, which can be metabolized by bacteria to produce butyrate, can be an intriguing new investigational approach to prevent immunotherapy-induced colitis and lead to improved patient outcomes.
    - Butyrate is a gut-microbiome-derived, anti-inflammatory metabolite that could be protective against ICI colitis, based on data from other forms of colitis.
    - Dietary prebiotic starches that can increase butyrate production are a promising method of microbial manipulation that could be used to mitigate ICI colitis.

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