Microbiome & Chronic Diseases

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Small intestinal bacterial overgrowth {40000142}

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Small intestinal bacterial overgrowth
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Shared Notes

  • [1.1
    - The most notable intrinsic factors preventing Small intestinal bacterial overgrowth are gastric acid and bile acid (BA) secretion, peristaltic movement, normal gut defense mechanisms, the production of mucin, gut antibacterial peptides, and prevention of bacterial retrograde translocation from the lower gut to the upper gut via the ileocecal valve.
    - Extrinsic factors preventing Small intestinal bacterial overgrowth include nutrient intake and diet, bacterial and viral infection, medications altering motility (prokinetics), and drugs modulating the gut microbiota, for instance, pre and probiotics, proton pump inhibitors, H2 blockers, and antibiotics.
    - Based on jejunal aspirate cultures, Escherichia coli, Streptococcus species (spp.), Pseudomonas aeruginosa, Staphylococcus spp., Acinetobacter baumannii, Acinetobacter lwoffii, Enterococcus faecium, Klebsiella pneumoniae, and Enterococcus faecalis were predominantly found in patients with SIBO who suffered altered GI motility.

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