Disease ⇒ Glaucoma {40000528}

Shared Reference Notes

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  - CD4+ T cells express integrin β7 in the gut—this is a protein encoded by the ITGB7 gene. - CD4+ T cells were reprogrammed in the gut in a way that allowed them to use integrin β7 to access the retina and attack retinal ganglion cells when transported through the blood. - test mice antibodies prevented the cells from interacting with a protein known as MAdCAM-1, which led to a reduction in inflammation in the eye and damage to the retina.

References Notes