MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Hypertension {40000141}

Record Keys
Definition:
Hypertension
Class:[  ]

Details
Other Terms:
HTN , HT, high blood pressure (HBP)
Initialisation date:
2020-09-06

Links

Meta Information
ICD:[  ]
Category:
Cardiovascular
MedDra ID:
10020772
MedDra Level:
pt

Notes

- Faecalibacterium, Oscillibacter, Roseburia, Bifidobacterium, Coprococcus, and Butyrivibrio, which were enriched in healthy controls, declined in pHTN and HTN patients.
- Prevotella copri thrives in a pro-inflammatory environment.
- The superoxide reductase and phosphoadenosine phosphosulphate reductase encoded by Prevotella copri may favor the development of inflammation.
- Colonization with Prevotella copri enhances body weight loss and exacerbates epithelial inflammation in colitis mouse model.
- The enterotype dominated by Prevotella was enriched with pHTN and HTN populations.
- Prevotella was overrepresented in individuals with pHTN and HTN.
- Stearic acid, an important metabolite in HTN, is positively linked to Prevotella.
- CAGs and species taxonomic annotated to Prevotella were the common microbial characteristics of pHTN and HTN, and contributed a lot to classification of HTN.
- Prevotella may play an essential role in HTN, probably by triggering the inflammatory response.
- Higher levels of the genus Ruminococcus were linked with increased risk of high blood pressure. (3)


Shared Notes

  • [1.7] 
    - Sodium reduction increased all 8 SCFAs, among which the increases in 2-methylbutyrate, butyrate, hexanoate, isobutyrate, and valerate were statistically significant.
    - Increased SCFAs were associated with decreased blood pressure and improved arterial compliance. There were significant sex differences of SCFAs in response to sodium reduction.
    - When stratified by sex, the increases in butyrate, hexanoate, isobutyrate, isovalerate, and valerate were significant in females only not in males.
    - In females, changes in isobutyrate, isovalerate, and 2-methylbutyrate were inversely associated with reduced blood pressures.
    - Increased valerate was associated with decreased carotid-femoral pulse wave velocity.
  • [1.8] 
    - Elevated putative succinate-producing bacteria and acetate-producing bacteria were associated with lower and higher mean arterial pressure in mouse, respectively
    - Prevotella and Klebsiella were overrepresented in individuals with pHTN or HTN.
  • [1.9] 
    - A. muciniphila may influence blood pressure through vitamin B1 production,
  • [1.10] 
    - The last receptor for SCFAs, Olf78, has been observed in the olfactory bulb, enteroendocrine cells, the kidney, blood vessels, skeletal muscle, and heart.
    - Olf78 seems responsive to acetate and propionate, but not butyrate, and induces an increase in blood pressure via renin secretion .
  • [1.11] 
    - A 5-day fast followed by a modified Dietary Approach to Stop Hypertension diet reduces systolic blood pressure, need for antihypertensive medications, body-mass index at three months post intervention compared to a modified Dietary Approach to Stop Hypertension diet alone.
    - Fasting alters the gut microbiome, impacting bacterial taxa and gene modules associated with short-chain fatty acid production.
  • - There is an antihypertensive effect of propionate treatment in mice.
  • [1.12] 
    - There was a positive association between 9,10-dichloro-octadecanoic acid (stearic acid) and microflora including Klebsiella, Prevotella, and Enterbacter, which were all overrepresented in HTN.
    - In HTN microbial richness and diversity are decreased with Prevotella-dominated gut enterotype.
  • [1.13] 
    - Nitrate-rich supplements, in turn, stimulate nitrate reduction by the oral microbiota resulting in a lowering of blood pressure.
  • [1.14] 
    - Bacteroidetes (Odoribacter and Alistipes genera), often contribute to the overall butyrogenic pool. SCFA-producing bacteria may affect blood pressure by direct effects of SCFA on vasodilation or through plasminogen activator inhibitor-1 (PAI-1)

Common References