Hypertension {40000141}
| Definition: | Hypertension |
|---|---|
| Class: | [ ] |
| Other Terms: | HTN , HT, high blood pressure (HBP) |
|---|---|
| Authoring date: | 2020-09-06 |
| ICD: | [ ] |
|---|---|
| Category: | Cardiovascular |
| MedDra ID: | 10020772 |
| MedDra Level: | pt |
Notes
- Faecalibacterium, Oscillibacter, Roseburia, Bifidobacterium, Coprococcus, and Butyrivibrio, which were enriched in healthy controls, declined in pHTN and HTN patients.
- Prevotella copri thrives in a pro-inflammatory environment.
- The superoxide reductase and phosphoadenosine phosphosulphate reductase encoded by Prevotella copri may favor the development of inflammation.
- Colonization with Prevotella copri enhances body weight loss and exacerbates epithelial inflammation in colitis mouse model.
- The enterotype dominated by Prevotella was enriched with pHTN and HTN populations.
- Prevotella was overrepresented in individuals with pHTN and HTN.
- Stearic acid, an important metabolite in HTN, is positively linked to Prevotella.
- CAGs and species taxonomic annotated to Prevotella were the common microbial characteristics of pHTN and HTN, and contributed a lot to classification of HTN.
- Prevotella may play an essential role in HTN, probably by triggering the inflammatory response.
- Higher levels of the genus Ruminococcus were linked with increased risk of high blood pressure. (3)
Shared Notes
- [1.8]
- Elevated putative succinate-producing bacteria and acetate-producing bacteria were associated with lower and higher mean arterial pressure in mouse, respectively
- Prevotella and Klebsiella were overrepresented in individuals with pHTN or HTN. - [1.9]
- There was a positive association between 9,10-dichloro-octadecanoic acid (stearic acid) and microflora including Klebsiella, Prevotella, and Enterbacter, which were all overrepresented in HTN.
- In HTN microbial richness and diversity are decreased with Prevotella-dominated gut enterotype. - [1.10]
- Bacteroidetes (Odoribacter and Alistipes genera), often contribute to the overall butyrogenic pool. SCFA-producing bacteria may affect blood pressure by direct effects of SCFA on vasodilation or through plasminogen activator inhibitor-1 (PAI-1) - [1.11]
- Nitrate-rich supplements, in turn, stimulate nitrate reduction by the oral microbiota resulting in a lowering of blood pressure. - [1.7]
- Sodium reduction increased all 8 SCFAs, among which the increases in 2-methylbutyrate, butyrate, hexanoate, isobutyrate, and valerate were statistically significant.
- Increased SCFAs were associated with decreased blood pressure and improved arterial compliance. There were significant sex differences of SCFAs in response to sodium reduction.
- When stratified by sex, the increases in butyrate, hexanoate, isobutyrate, isovalerate, and valerate were significant in females only not in males.
- In females, changes in isobutyrate, isovalerate, and 2-methylbutyrate were inversely associated with reduced blood pressures.
- Increased valerate was associated with decreased carotid-femoral pulse wave velocity.
Common References
- [1.1] DUBLICATE_2_Gut microbiota dysbiosis contributes to the development of hypertension [2017] [80000428] [Microbiome]
- [1.2] DUBLICATE_1_Gut microbiota dysbiosis contributes to the development of hypertension [2017] [80001330] [Microbiome]
- [1.3] Hypertension is associated with intestinal microbiota dysbiosis and inflammation in a Brazilian population [2020] [80001373] [Frontiers in Pharmacology]
- [1.4] Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure [2018] [80000785] [Clinical Science (London)]
- [1.5] Alterations of the gut microbiome in hypertension [2017] [80000630] [Frontiers in Cellular and Infection Microbiology]
- [1.6] Molecular characterization of alterations in the intestinal microbiota of patients with grade 3 hypertension [2019] [80001166] [International Journal of Molecular Medicine]
- [1.7] Modest Sodium Reduction Increases Circulating Short-Chain Fatty Acids in Untreated Hypertensives [2020] [Research] [80001481] [Hypertension]
- [1.8] Sleep fragmentation increases blood pressure and is associated with alterations in the gut microbiome and fecal metabolome in rats [2020] [Research] [80000153] [Physiological genomics]
- [1.9] Gut microbiota dysbiosis contributes to the development of hypertension [2017] [Report] [80000033] [Microbiome]
- [1.10] Increased Systolic and Diastolic Blood Pressure Is Associated With Altered Gut Microbiota Composition and Butyrate Production in Early Pregnancy [2016] [Research] [80000090] [Hypertension]
- [1.11] Isolation and Characterization of Nitrate-Reducing Bacteria as Potential Probiotics for Oral and Systemic Health [2020] [Research] [80000216] [Frontiers in Microbiology]