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- Middle‐aged and old patients with vitiligo are more likely to develop dementia compared with those without vitiligo.
- Low B-12 not only causes central nervous system (CNS) damage by decreasing availability of methyl groups, but also allows accumulation of homocysteine, which appears to be toxic to nerve cells and blocks N-methyl-dasparate receptors.
- It is also important to remember that for B-12 by itself to be functional, it needs to be converted to glutathionyl cobalamin, which requires glutathione for its synthesis. Oxidative stress can tie up glutathione and contribute further to lack of B-12 function.
- High equol producers had >50% lower WML% than non-producers.
- Equol‐producing status (non‐producers, low and high) was significantly inversely associated with WML%. (1)
- [1.1] Associations of equol‐producing status with white matter lesion and amyloid‐β deposition in cognitively normal elderly Japanese  [Research] [Alzheimer's & Dementia] [Journal] 
- [1.2] Association between vitiligo and subsequent risk of dementia: A population‐based cohort study  [Abstract] [Journal of Dermatology] [Journal] 
- [1.3] Are We Overlooking B-12 Deficiency as a Cause of Dementia?  [Case study]