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Microbiome & Chronic Diseases

Evidence Based Medicine
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Disease ⇒ Dementia {40000512}

Record Keys


Type:
Disease
Definition:
Dementia
Parent:[  ]

Details


Initialisation date:
2020-10-23
Other Terms:
ccyc

Meta Information


MedDra ID:[  ]
MedDra Level:[  ]
ICD:[  ]
Category:
Neurology
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


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Shared Reference Notes


  • [1.6
    - Middle‐aged and old patients with vitiligo are more likely to develop dementia compared with those without vitiligo.
  • [1.5
    - Low B-12 not only causes central nervous system (CNS) damage by decreasing availability of methyl groups, but also allows accumulation of homocysteine, which appears to be toxic to nerve cells and blocks N-methyl-dasparate receptors.
    - It is also important to remember that for B-12 by itself to be functional, it needs to be converted to glutathionyl cobalamin, which requires glutathione for its synthesis. Oxidative stress can tie up glutathione and contribute further to lack of B-12 function.
  • [1.3
    - High equol producers had >50% lower WML% than non-producers.
    - Equol‐producing status (non‐producers, low and high) was significantly inversely associated with WML%. (1)
  • [1.2
    - Dietary fiber intake was inversely associated with risk of dementia.
    - The inverse association was more evident for soluble fiber intake and was confined to dementia without a history of stroke.
  • [1.4
    - Vitamin B12 deficiency at the brain level is associated with affective disorders, behavior changes, psychosis, cognitive impairment or decline, and dementia (including Alzheimer’s disease and vascular dementia protection)

Common References