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- Middle‐aged and old patients with vitiligo are more likely to develop dementia compared with those without vitiligo.
- Low B-12 not only causes central nervous system (CNS) damage by decreasing availability of methyl groups, but also allows accumulation of homocysteine, which appears to be toxic to nerve cells and blocks N-methyl-dasparate receptors.
- It is also important to remember that for B-12 by itself to be functional, it needs to be converted to glutathionyl cobalamin, which requires glutathione for its synthesis. Oxidative stress can tie up glutathione and contribute further to lack of B-12 function.
- High equol producers had >50% lower WML% than non-producers.
- Equol‐producing status (non‐producers, low and high) was significantly inversely associated with WML%. (1)