Asthma {40000140}

Record Keys
Definition:	Asthma
Class:	[ ]

Details
Other Terms:	[ ]
Initialisation date:	2020-09-06

Links
Wickipedia Merck Manual

Meta Information
ICD:	[ ]
Category:	Pulmonary
MedDra ID:	10003553
MedDra Level:	pt

Notes

[ ]

Shared Notes

[1.18]
- Differences in the fungal community were more strongly associated with asthma risk than bacterial dysbiosis.
- Overrepresentation of total fungal sequences and an expansion of the yeast Issatchenkia orientalis in children who later developed symptoms
[1.19]
- Increased maternal dietary microbiome-accessible fiber and SCFA exposure during pregnancy, may result in a reduced incidence of asthma in offspring which persists into adulthood.
- An association exists between there is an areduced dietary fiber intake and reduced serum acetate levels in pregnant women.
- The serum acetate levels that were lower than the median, is related to increased frequency of coughing/wheezing during the child’s first year of life.
- During pregnancy, SCFA (such as acetate) can cross the placenta and affect the expression of fetal lung genes, such as NPPA, which encodes ANP (a molecule related to epithelial biology and immune regulation).
[1.20]
- Severe respiratory viral infection with respiratory syncytial virus (RSV) and rhinovirus (RV) is associated with increased risk of developing asthma, and as such, these viruses are considered asthmagenic.
- Mice nasally exposed to two distinct strains of the commensal bacterial species Lactobacillus rhamnosus (LR05 and LR06) were protected against subsequent RSV infection.
- Protection was associated with increased levels of IFN-β, IFN-γ, IL-6, and TNF-α in both BAL and serum samples, which contributed to viral clearance.

Common References

[1.1] Airway microbiome in different inflammatory phenotypes of asthma: a cross-sectional study in northeast China [2019] [International Journal of Medical Sciences] [Journal] [80000997]
[1.2] Aerodigestive dysbiosis in children with chronic cough [2018] [Pediatric Pulmonology] [Journal] [80000729]
[1.3] Lower airway microbiota and mycobiota in children with sever asthma [2018] [Journal of Allergy and Clinical Immunology] [Journal] [80001065]
[1.4] Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma [2016] [Clinical Science] [Journal] [80000731]
[1.5] Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma [2011] [Journal of Allergy and Clinical Immunology] [Journal] [80000535]
[1.6] Sputum microbiota in severe asthma patients: relationship to eosinophilic inflammation [2017] [Respiratory Medicine] [Journal] [80000732]
[1.7] Fecal microbiota profile in atopic asthmatic adult patients [2018] [European Annals of Allergy and Clinical Immunology] [Journal] [80000672]
[1.8] Asthma-associated differences in microbial composition of induced sputum [2013] [Journal of Allergy and Clinical Immunology] [Journal] [80000555]
[1.9] Comparison of oropharyngeal microbiota from children with asthma and cystic fibrosis [2017] [Mediators of Inflammation] [Journal] [80000734]
[1.10] The infant airway microbiome in health and disease impacts later asthma development [2015] [Cell Host Microbe] [Journal] [80000735]
[1.11] The airway microbiome in patients with severe asthma: associations with disease features and severity [2015] [Journal of Allergy and Clinical Immunology] [Journal] [80000408]
[1.12] Microbial communities in the upper respiratory tract of patients with asthma and chronic obstructive pulmonary disease. [2014] [PLOS ONE] [Journal] [80000380]
[1.13] Bacterial microbiota of the upper respiratory tract and childhood asthma [2017] [The Journal of Allergy and Clinical Immunology] [Journal] [80000511]
[1.14] Different upper airway microbiome and their functional genes associated with asthma in young adults and elderly individuals [2019] [Allergy] [Journal] [80001003]
[1.15] Bacterial salivary microbiome associates with asthma among african american children and young adults [2019] [Pediatric Pulmonology] [Journal] [80001130]
[1.16] A low abundance of Bifidobacterium but not Lactobacillus in the feces of Chinese children with wheezing diseases [2018] [Medicine] [Journal] [80000872]
[1.17] Early infancy microbial and metabolic alterations affect risk of childhood asthma [2015] [Science translational medicine] [Journal] [80000526]
[1.18] Intestinal fungi are causally implicated in microbiome assembly and immune development in mice [2020] [Review] [Nature communications] [Journal] [80001855]
[1.19] Maternal Vegetable and Fruit Consumption during Pregnancy and Its Effects on Infant Gut Microbiome [2021] [Clinical study] [Nutrients] [Journal] [80001899]
[1.20] Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome [2015] [Research] [Cell Host & Microbe] [Journal] [80000032]

Increased abundance of

‐ Acidaminococcus Sputum ‎Human [1.1]

‐ Actinomyces Bronchoalveolar lavage ‎Human [1.2]

‐ Adlercreutzia Sputum ‎Human [1.1]

‐ Alistipes Bronchoalveolar lavage ‎Human [1.3]

‐ Anaerostipes Bronchoalveolar lavage ‎Human [1.3]

‐ Bacteroides Bronchoalveolar lavage ‎Human [1.3]

‐ Cellulomonas Sputum ‎Human [1.1]

‐ Clostridiaceae Faeces ‎Human [1.4]

‐ Clostridium neonatale Faeces ‎Human [1.4]

‐ Comamonadaceae Bronchial brush ‎Human [1.5]

‐ Eisenbergiella Bronchoalveolar lavage ‎Human [1.3]

‐ Enterobacteriaceae Sputum ‎Human [1.6]

‐ Escherichia coli Faeces ‎Human [1.7]

‐ Eubacterium Bronchoalveolar lavage ‎Human [1.3]

‐ Faecalibacterium Bronchoalveolar lavage ‎Human [1.3]

‐ Flavonifractor Bronchoalveolar lavage ‎Human [1.3]

‐ Frigoribacterium Sputum ‎Human [1.1]

‐ Gallibacterium Bronchoalveolar lavage ‎Human [1.2]

‐ Gammaproteobacteria Sputum ‎Human [1.8]

‐ Gemella Bronchoalveolar lavage ‎Human [1.2]

‐ Gemella Swab throat ‎Human [1.9]

‐ Georgenia Sputum ‎Human [1.1]

‐ Glaciecola Sputum ‎Human [1.1]

‐ Granulicatella Bronchoalveolar lavage ‎Human [1.2]

‐ Granulicatella Sputum ‎Human [1.1]

‐ Haemophilus Nasopharyngeal aspirate ‎Human [1.10]

‐ Haemophilus Swab throat ‎Human [1.9]

‐ Helicobacter Sputum ‎Human [1.1]

‐ Klebsiella Bronchial brush ‎Human [1.11]

‐ Lactobacillus rhamnosus ‎Preventive

‐ Lactobacillus Faeces ‎Human [1.7]

‐ Lactobacillus Oropharynx swab ‎Human [1.12]

‐ Leclercia Bronchial brush ‎Human [1.11]

‐ Leucosporidium Bronchoalveolar lavage ‎Human [1.3]

‐ Moraxella Nasal swab ‎Human [1.13]

‐ Moraxella Nasopharyngeal aspirate ‎Human [1.10]

‐ Nitrosomonadaceae Bronchial brush ‎Human [1.5]

‐ Odoribacter Bronchoalveolar lavage ‎Human [1.3]

‐ Oribacterium Bronchoalveolar lavage ‎Human [1.2]

‐ Oscillibacter Bronchoalveolar lavage ‎Human [1.3]

‐ Oxalobacteraceae Bronchial brush ‎Human [1.5]

‐ Parabacteroides Bronchoalveolar lavage ‎Human [1.3]

‐ Planococcaceae Bronchoalveolar lavage ‎Human [1.2]

‐ Pneumocystis Bronchoalveolar lavage ‎Human [1.3]

‐ Proteobacteria Nasopharyngeal swab ‎Human [1.14]

‐ Proteobacteria Sputum ‎Human [1.8]

‐ Pseudomonadaceae Bronchial brush ‎Human [1.5]

‐ Pseudomonadaceae Sputum ‎Human [1.6]

‐ Pseudomonas Oropharynx swab ‎Human [1.12]

‐ Pyramidobacter Sputum ‎Human [1.1]

‐ Rhodosporidium Bronchoalveolar lavage ‎Human [1.3]

‐ Rhodotorula Bronchoalveolar lavage ‎Human [1.3]

‐ Romboutsia Bronchoalveolar lavage ‎Human [1.3]

‐ Roseburia Bronchoalveolar lavage ‎Human [1.3]

‐ Rothia Bronchoalveolar lavage ‎Human [1.2]

‐ Rothia Faeces ‎Human [1.4]

‐ Rothia Sputum ‎Human [1.1]

‐ Rubellimicrobium Sputum ‎Human [1.1]

‐ Ruminococcus Bronchoalveolar lavage ‎Human [1.3]

‐ Sarcandra Sputum ‎Human [1.1]

‐ Sphingomonadaceae Bronchial brush ‎Human [1.5]

‐ Stenotrophomonas Oropharynx swab ‎Human [1.12]

‐ Streptococcus Nasopharyngeal aspirate ‎Human [1.10]

‐ TM7 Bronchoalveolar lavage ‎Human [1.2]

‐ Veillonella Saliva ‎Human [1.15]

‐ Weeksella Bronchoalveolar lavage ‎Human [1.2]

Decreased abundance of

‐ Acinetobacter Sputum ‎Human [1.1]

‐ Actinobacillus Sputum ‎Human [1.1]

‐ Aggregatibacter Sputum ‎Human [1.1]

‐ Alicyclobacillus Sputum ‎Human [1.1]

‐ Alloiococcus Nasopharyngeal aspirate ‎Human [1.10]

‐ Anaerovorax Sputum ‎Human [1.1]

‐ Bifidobacterium Faeces ‎Human [1.16]

‐ Brevundimonas Sputum ‎Human [1.1]

‐ Bulleidia Sputum ‎Human [1.1]

‐ Butyrivibrio Sputum ‎Human [1.1]

‐ Capnocytophaga Bronchoalveolar lavage ‎Human [1.3]

‐ Catonella Sputum ‎Human [1.1]

‐ Corynebacterium Nasopharyngeal aspirate ‎Human [1.10]

‐ Corynebacterium Nasopharyngeal swab ‎Human [1.14]

‐ Cryptococcus Bronchoalveolar lavage ‎Human [1.3]

‐ Davidiella Bronchoalveolar lavage ‎Human [1.3]

‐ Deinococcus Sputum ‎Human [1.1]

‐ Dermabacter Sputum ‎Human [1.1]

‐ Desulfomicrobium Sputum ‎Human [1.1]

‐ Dialister Sputum ‎Human [1.1]

‐ Enterococcus Sputum ‎Human [1.1]

‐ Faecalibacterium Faeces ‎Human [1.17]

‐ Filifactor Sputum ‎Human [1.1]

‐ Fusobacterium Sputum ‎Human [1.1]

‐ Lachnospira Faeces ‎Human [1.17]

‐ Lampropedia Sputum ‎Human [1.1]

‐ Leptotrichia Sputum ‎Human [1.1]

‐ Leuconostoc Sputum ‎Human [1.1]

‐ Moraxella Nasopharyngeal swab ‎Human [1.14]

‐ Moraxella Sputum ‎Human [1.1]

‐ Mycobacterium Sputum ‎Human [1.1]

‐ Mycoplana Sputum ‎Human [1.1]

‐ Neisseria Oropharynx swab ‎Human [1.12]

‐ Nevskia Sputum ‎Human [1.1]

‐ Oribacterium Sputum ‎Human [1.1]

‐ Paludibacter Sputum ‎Human [1.1]

‐ Parvimonas Sputum ‎Human [1.1]

‐ Peptococcus Sputum ‎Human [1.1]

‐ Phyllobacterium Sputum ‎Human [1.1]

‐ Porphyromonadaceae Sputum ‎Human [1.6]

‐ Prevotella Oropharynx swab ‎Human [1.12]

‐ Prevotella Sputum ‎Human [1.1]

‐ Prevotella Swab throat ‎Human [1.9]

‐ Proteus Bronchoalveolar lavage ‎Human [1.3]

‐ Rothia Faeces ‎Human [1.17]

‐ Sanguibacter Sputum ‎Human [1.1]

‐ Skermanella Sputum ‎Human [1.1]

‐ Slackia Sputum ‎Human [1.1]

‐ Sporosarcina Sputum ‎Human [1.1]

‐ Staphylococcus Nasopharyngeal aspirate ‎Human [1.10]

‐ Staphylococcus Sputum ‎Human [1.1]

‐ Sterigmatomyces Bronchoalveolar lavage ‎Human [1.3]

‐ Streptococcus Oropharynx swab ‎Human [1.12]

‐ Streptococcus Saliva ‎Human [1.15]

‐ Tannerella Sputum ‎Human [1.1]

‐ Treponema Sputum ‎Human [1.1]

‐ Veillonella Faeces ‎Human [1.17]

‐ Veillonella Oropharynx swab ‎Human [1.12]

‐ Veillonella Swab throat ‎Human [1.9]

‐ Virgibacillus Sputum ‎Human [1.1]

‐ Wolinella Sputum ‎Human [1.1]

‐ Yaniella Sputum ‎Human [1.1]

Asthma {40000140}

Record Keys

Details

Links

Meta Information

Notes

Shared Notes

Common References