Disease ⇒ Asthma {40000140}

Record Keys
Type:	Disease
Definition:	Asthma
Parent:	[ ]

Details
Initialisation date:	2020-09-06
Other Terms:	[ ]

Links
Wickipedia Merck Manual

Meta Information
MedDra ID:	10003553
MedDra Level:	pt
ICD:	[ ]
Category:	Pulmonary
Zone:	[ ]
Mechanism:	[ ]

Notes:

[ ]

References Notes

[ ]

Shared Reference Notes

[1.19]
- Differences in the fungal community were more strongly associated with asthma risk than bacterial dysbiosis.
- Overrepresentation of total fungal sequences and an expansion of the yeast Issatchenkia orientalis in children who later developed symptoms
[1.20]
- Increased maternal dietary microbiome-accessible fiber and SCFA exposure during pregnancy > reduced incidence of asthma in offspring which persists into adulthood.
- Reduced dietary fiber intake > reduced serum acetate levels in pregnant women > increased frequency of coughing/wheezing during the child’s first year of life.
- During pregnancy > SCFA (such as acetate) > cross the placenta and affect the expression of fetal lung genes, such as NPPA, > encodes ANP (a molecule related to epithelial biology and immune regulation).
[1.21]
- Severe respiratory viral infection with respiratory syncytial virus (RSV) and rhinovirus (RV) is associated with increased risk of developing asthma, and as such, these viruses are considered asthmagenic.
- Mice nasally exposed to two distinct strains of the commensal bacterial species Lactobacillus rhamnosus (LR05 and LR06) were protected against subsequent RSV infection.
- Protection was associated with increased levels of IFN-β, IFN-γ, IL-6, and TNF-α in both BAL and serum samples, which contributed to viral clearance.
[1.24]
- siblings in the home to be one of the most important determinants of the developing microbiota in both the airway and gut, with significant differences in alpha diversity, beta diversity, and relative abundances of the most abundant taxa, with the specific associations being particularly apparent during the first year of life.
- The age gap to the closest older sibling was more important than the number of older siblings. The signature of having siblings in the gut microbiota at 1 year was associated with protection against asthma at 6 years of age, while no associations were found for allergy.

↥ Abundance

‐ Acidaminococcus ‎Sputum ‎Human [1.1]
‐ Actinomyces ‎Bronchoalveolar lavage ‎Human [1.2]
‐ Adlercreutzia ‎Sputum ‎Human [1.1]
‐ Alistipes ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Anaerostipes ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Bacteroides ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Cellulomonas ‎Sputum ‎Human [1.1]
‐ Clostridiaceae ‎Stool ‎Human [1.4]
‐ Clostridium neonatale ‎Stool ‎Human [1.4]
‐ Comamonadaceae ‎Bronchial brush ‎Human [1.5]
‐ Eisenbergiella ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Enterobacteriaceae ‎Sputum ‎Human [1.6]
‐ Escherichia coli ‎Stool ‎Human [1.7]
‐ Eubacterium ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Faecalibacterium ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Flavonifractor ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Frigoribacterium ‎Sputum ‎Human [1.1]
‐ Gallibacterium ‎Bronchoalveolar lavage ‎Human [1.2]
‐ Gammaproteobacteria ‎Sputum ‎Human [1.8]
‐ Gemella ‎Bronchoalveolar lavage ‎Human [1.2]
‐ Gemella ‎Swab throat ‎Human [1.9]
‐ Georgenia ‎Sputum ‎Human [1.1]
‐ Glaciecola ‎Sputum ‎Human [1.1]
‐ Granulicatella ‎Bronchoalveolar lavage ‎Human [1.2]
‐ Granulicatella ‎Sputum ‎Human [1.1]
‐ Haemophilus ‎Nasopharyngeal aspirate ‎Human [1.10]
‐ Haemophilus ‎Swab throat ‎Human [1.9]
‐ Helicobacter ‎Sputum ‎Human [1.1]
‐ Klebsiella ‎Bronchial brush ‎Human [1.11]
‐ Lactobacillus rhamnosus ‎Preventive ‎Gut Lumen ‎Human
‐ Lactobacillus ‎Oropharynx swab ‎Human [1.12]
‐ Lactobacillus ‎Stool ‎Human [1.7]
‐ Leclercia ‎Bronchial brush ‎Human [1.11]
‐ Leucosporidium ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Moraxella ‎Nasal swab ‎Human [1.13]
‐ Moraxella ‎Nasopharyngeal aspirate ‎Human [1.10]
‐ Nitrosomonadaceae ‎Bronchial brush ‎Human [1.5]
‐ Odoribacter ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Oribacterium ‎Bronchoalveolar lavage ‎Human [1.2]
‐ Oscillibacter ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Oxalobacteraceae ‎Bronchial brush ‎Human [1.5]
‐ Parabacteroides ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Planococcaceae ‎Bronchoalveolar lavage ‎Human [1.2]
‐ Pneumocystis ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Proteobacteria ‎Nasopharyngeal swab ‎Human [1.14]
‐ Proteobacteria ‎Sputum ‎Human [1.8]
‐ Pseudomonadaceae ‎Bronchial brush ‎Human [1.5]
‐ Pseudomonadaceae ‎Sputum ‎Human [1.6]
‐ Pseudomonas ‎Oropharynx swab ‎Human [1.12]
‐ Pyramidobacter ‎Sputum ‎Human [1.1]
‐ Rhodosporidium ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Rhodotorula ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Romboutsia ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Roseburia ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Rothia ‎Bronchoalveolar lavage ‎Human [1.2]
‐ Rothia ‎Sputum ‎Human [1.1]
‐ Rothia ‎Stool ‎Human [1.4]
‐ Rubellimicrobium ‎Sputum ‎Human [1.1]
‐ Ruminococcus ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Sarcandra ‎Sputum ‎Human [1.1]
‐ Sphingomonadaceae ‎Bronchial brush ‎Human [1.5]
‐ Stenotrophomonas ‎Oropharynx swab ‎Human [1.12]
‐ Streptococcus ‎Nasopharyngeal aspirate ‎Human [1.10]
‐ TM7 ‎Bronchoalveolar lavage ‎Human [1.2]
‐ Veillonella ‎Saliva ‎Human [1.15]
‐ Weeksella ‎Bronchoalveolar lavage ‎Human [1.2]

↧ Abundance

‐ Acinetobacter ‎Sputum ‎Human [1.1]
‐ Actinobacillus ‎Sputum ‎Human [1.1]
‐ Aggregatibacter ‎Sputum ‎Human [1.1]
‐ Alicyclobacillus ‎Sputum ‎Human [1.1]
‐ Alloiococcus ‎Nasopharyngeal aspirate ‎Human [1.10]
‐ Anaerovorax ‎Sputum ‎Human [1.1]
‐ Bifidobacterium ‎Stool ‎Human [1.16]
‐ Brevundimonas ‎Sputum ‎Human [1.1]
‐ Bulleidia ‎Sputum ‎Human [1.1]
‐ Butyrivibrio ‎Sputum ‎Human [1.1]
‐ Capnocytophaga ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Catonella ‎Sputum ‎Human [1.1]
‐ Corynebacterium ‎Nasopharyngeal aspirate ‎Human [1.10]
‐ Corynebacterium ‎Nasopharyngeal swab ‎Human [1.14]
‐ Cryptococcus ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Davidiella ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Deinococcus ‎Sputum ‎Human [1.1]
‐ Dermabacter ‎Sputum ‎Human [1.1]
‐ Desulfomicrobium ‎Sputum ‎Human [1.1]
‐ Dialister ‎Sputum ‎Human [1.1]
‐ Enterococcus ‎Sputum ‎Human [1.1]
‐ Faecalibacterium ‎Stool ‎Human [1.17]
‐ Filifactor ‎Sputum ‎Human [1.1]
‐ Fusobacterium ‎Sputum ‎Human [1.1]
‐ Lachnospira ‎Stool ‎Human [1.17]
‐ Lampropedia ‎Sputum ‎Human [1.1]
‐ Leptotrichia ‎Sputum ‎Human [1.1]
‐ Leuconostoc ‎Sputum ‎Human [1.1]
‐ Moraxella ‎Nasopharyngeal swab ‎Human [1.14]
‐ Moraxella ‎Sputum ‎Human [1.1]
‐ Mycobacterium ‎Sputum ‎Human [1.1]
‐ Mycoplana ‎Sputum ‎Human [1.1]
‐ Neisseria ‎Oropharynx swab ‎Human [1.12]
‐ Nevskia ‎Sputum ‎Human [1.1]
‐ Oribacterium ‎Sputum ‎Human [1.1]
‐ Paludibacter ‎Sputum ‎Human [1.1]
‐ Parvimonas ‎Sputum ‎Human [1.1]
‐ Peptococcus ‎Sputum ‎Human [1.1]
‐ Phyllobacterium ‎Sputum ‎Human [1.1]
‐ Porphyromonadaceae ‎Sputum ‎Human [1.6]
‐ Prevotella ‎Oropharynx swab ‎Human [1.12]
‐ Prevotella ‎Sputum ‎Human [1.1]
‐ Prevotella ‎Swab throat ‎Human [1.9]
‐ Proteus ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Rothia ‎Stool ‎Human [1.17]
‐ Sanguibacter ‎Sputum ‎Human [1.1]
‐ Skermanella ‎Sputum ‎Human [1.1]
‐ Slackia ‎Sputum ‎Human [1.1]
‐ Sporosarcina ‎Sputum ‎Human [1.1]
‐ Staphylococcus ‎Nasopharyngeal aspirate ‎Human [1.10]
‐ Staphylococcus ‎Sputum ‎Human [1.1]
‐ Sterigmatomyces ‎Bronchoalveolar lavage ‎Human [1.3]
‐ Streptococcus ‎Oropharynx swab ‎Human [1.12]
‐ Streptococcus ‎Saliva ‎Human [1.15]
‐ Tannerella ‎Sputum ‎Human [1.1]
‐ Treponema ‎Sputum ‎Human [1.1]
‐ Veillonella ‎Oropharynx swab ‎Human [1.12]
‐ Veillonella ‎Stool ‎Human [1.17]
‐ Veillonella ‎Swab throat ‎Human [1.9]
‐ Virgibacillus ‎Sputum ‎Human [1.1]
‐ Wolinella ‎Sputum ‎Human [1.1]
‐ Yaniella ‎Sputum ‎Human [1.1]

Related Factor

‐ High-fiber diet [1.18]

Subclass

[ ]

Related Metabolome

[ ]

References

[ ]

Common References

[1.1] Airway microbiome in different inflammatory phenotypes of asthma: a cross-sectional study in northeast China [2019] [International Journal of Medical Sciences] [Journal] [80000997]
[1.2] Aerodigestive dysbiosis in children with chronic cough [2018] [Pediatric Pulmonology] [Journal] [80000729]
[1.3] Lower airway microbiota and mycobiota in children with sever asthma [2018] [Journal of Allergy and Clinical Immunology] [Journal] [80001065]
[1.4] Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma [2016] [Clinical Science] [Journal] [80000731]
[1.5] Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma [2011] [Journal of Allergy and Clinical Immunology] [Journal] [80000535]
[1.6] Sputum microbiota in severe asthma patients: relationship to eosinophilic inflammation [2017] [Respiratory Medicine] [Journal] [80000732]
[1.7] Fecal microbiota profile in atopic asthmatic adult patients [2018] [European Annals of Allergy and Clinical Immunology] [Journal] [80000672]
[1.8] Asthma-associated differences in microbial composition of induced sputum [2013] [Journal of Allergy and Clinical Immunology] [Journal] [80000555]
[1.9] Comparison of oropharyngeal microbiota from children with asthma and cystic fibrosis [2017] [Mediators of Inflammation] [Journal] [80000734]
[1.10] The infant airway microbiome in health and disease impacts later asthma development [2015] [Cell Host Microbe] [Journal] [80000735]
[1.11] The airway microbiome in patients with severe asthma: associations with disease features and severity [2015] [Journal of Allergy and Clinical Immunology] [Journal] [80000408]
[1.12] Microbial communities in the upper respiratory tract of patients with asthma and chronic obstructive pulmonary disease. [2014] [PLOS ONE] [Journal] [80000380]
[1.13] Bacterial microbiota of the upper respiratory tract and childhood asthma [2017] [The Journal of Allergy and Clinical Immunology] [Journal] [80000511]
[1.14] Different upper airway microbiome and their functional genes associated with asthma in young adults and elderly individuals [2019] [Allergy] [Journal] [80001003]
[1.15] Bacterial salivary microbiome associates with asthma among african american children and young adults [2019] [Pediatric Pulmonology] [Journal] [80001130]
[1.16] A low abundance of Bifidobacterium but not Lactobacillus in the feces of Chinese children with wheezing diseases [2018] [Medicine] [Journal] [80000872]
[1.17] Early infancy microbial and metabolic alterations affect risk of childhood asthma [2015] [Science translational medicine] [Journal] [80000526]
[1.18] Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms [2014] [Review] [Bioessays] [Journal] [80001843]
[1.19] Intestinal fungi are causally implicated in microbiome assembly and immune development in mice [2020] [Review] [Nature communications] [Journal] [80001855]
[1.20] Maternal Vegetable and Fruit Consumption during Pregnancy and Its Effects on Infant Gut Microbiome [2021] [Clinical study] [Nutrients] [Journal] [80001899]
[1.21] Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome [2015] [Research] [Cell Host & Microbe] [Journal] [80000032]
[1.22] Relationships Between Oral Microecosystem and Respiratory Diseases [2021] [Review] [Frontiers in Molecular Biosciences] [Journal] [80002192]
[1.23] The “Hygiene Hypothesis” and the Lessons Learnt From Farm Studies [2021] [Letter] [Frontiers in Immunology] [Journal] [80002440]
[1.24] The developing airway and gut microbiota in early life is influenced by age of older siblings [2022] [Cohort study] [Microbiome] [Journal] [80002514]

Disease ⇒ Asthma {40000140}

Record Keys

Details

Links

Meta Information

Notes:

References Notes

Shared Reference Notes

Common References