Microbiome & Chronic Diseases

Evidence Based Medicine

Asthma {40000140}

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Shared Notes

  • [1.18
    - Differences in the fungal community were more strongly associated with asthma risk than bacterial dysbiosis.
    - Overrepresentation of total fungal sequences and an expansion of the yeast Issatchenkia orientalis in children who later developed symptoms
  • [1.19
    - Increased maternal dietary microbiome-accessible fiber and SCFA exposure during pregnancy, may result in a reduced incidence of asthma in offspring which persists into adulthood.
    - An association exists between there is an areduced dietary fiber intake and reduced serum acetate levels in pregnant women.
    - The serum acetate levels that were lower than the median, is related to increased frequency of coughing/wheezing during the child’s first year of life.
    - During pregnancy, SCFA (such as acetate) can cross the placenta and affect the expression of fetal lung genes, such as NPPA, which encodes ANP (a molecule related to epithelial biology and immune regulation).
  • [1.20
    - Severe respiratory viral infection with respiratory syncytial virus (RSV) and rhinovirus (RV) is associated with increased risk of developing asthma, and as such, these viruses are considered asthmagenic.
    - Mice nasally exposed to two distinct strains of the commensal bacterial species Lactobacillus rhamnosus (LR05 and LR06) were protected against subsequent RSV infection.
    - Protection was associated with increased levels of IFN-β, IFN-γ, IL-6, and TNF-α in both BAL and serum samples, which contributed to viral clearance.

Common References