Asthma {40000140}

Record Keys
Definition:	Asthma
Class:	[ ]

Details
Other Terms:	[ ]
Authoring date:	2020-09-06

Links
Wickipedia Merck Manual

Meta Information
ICD:	[ ]
Category:	Pulmonary
MedDra ID:	10003553
MedDra Level:	pt

Notes

[ ]

Shared Notes

[1.18]
- Severe respiratory viral infection with respiratory syncytial virus (RSV) and rhinovirus (RV) is associated with increased risk of developing asthma, and as such, these viruses are considered asthmagenic.
- Mice nasally exposed to two distinct strains of the commensal bacterial species Lactobacillus rhamnosus (LR05 and LR06) were protected against subsequent RSV infection.
- Protection was associated with increased levels of IFN-β, IFN-γ, IL-6, and TNF-α in both BAL and serum samples, which contributed to viral clearance.

Common References

[1.1] Airway microbiome in different inflammatory phenotypes of asthma: a cross-sectional study in northeast China [2019] [80000997] [International Journal of Medical Sciences]
[1.2] Aerodigestive dysbiosis in children with chronic cough [2018] [80000729] [Pediatric Pulmonology]
[1.3] Lower airway microbiota and mycobiota in children with sever asthma [2018] [80001065] [Journal of Allergy and Clinical Immunology]
[1.4] Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma [2016] [80000731] [Clinical Science]
[1.5] Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma [2011] [80000535] [Journal of Allergy and Clinical Immunology]
[1.6] Sputum microbiota in severe asthma patients: relationship to eosinophilic inflammation [2017] [80000732] [Respiratory Medicine]
[1.7] Fecal microbiota profile in atopic asthmatic adult patients [2018] [80000672] [European Annals of Allergy and Clinical Immunology]
[1.8] Asthma-associated differences in microbial composition of induced sputum [2013] [80000555] [Journal of Allergy and Clinical Immunology]
[1.9] Comparison of oropharyngeal microbiota from children with asthma and cystic fibrosis [2017] [80000734] [Mediators of Inflammation]
[1.10] The infant airway microbiome in health and disease impacts later asthma development [2015] [80000735] [Cell Host Microbe]
[1.11] The airway microbiome in patients with severe asthma: associations with disease features and severity [2015] [80000408] [Journal of Allergy and Clinical Immunology]
[1.12] Microbial communities in the upper respiratory tract of patients with asthma and chronic obstructive pulmonary disease. [2014] [80000380] [PLOS ONE]
[1.13] Bacterial microbiota of the upper respiratory tract and childhood asthma [2017] [80000511] [The Journal of Allergy and Clinical Immunology]
[1.14] Different upper airway microbiome and their functional genes associated with asthma in young adults and elderly individuals [2019] [80001003] [Allergy]
[1.15] Bacterial salivary microbiome associates with asthma among african american children and young adults [2019] [80001130] [Pediatric Pulmonology]
[1.16] A low abundance of Bifidobacterium but not Lactobacillus in the feces of Chinese children with wheezing diseases [2018] [80000872] [Medicine]
[1.17] Early infancy microbial and metabolic alterations affect risk of childhood asthma [2015] [80000526] [Science translational medicine]
[1.18] Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome [2015] [Research] [80000032] [Cell Host & Microbe]

Increased abundance of

‐ Acidaminococcus Sputum ‎Human [1.1]

‐ Actinomyces Bronchoalveolar lavage ‎Human [1.2]

‐ Adlercreutzia Sputum ‎Human [1.1]

‐ Alistipes Bronchoalveolar lavage ‎Human [1.3]

‐ Anaerostipes Bronchoalveolar lavage ‎Human [1.3]

‐ Bacteroides Bronchoalveolar lavage ‎Human [1.3]

‐ Cellulomonas Sputum ‎Human [1.1]

‐ Clostridiaceae Faeces ‎Human [1.4]

‐ Clostridium neonatale Faeces ‎Human [1.4]

‐ Comamonadaceae Bronchial brush ‎Human [1.5]

‐ Eisenbergiella Bronchoalveolar lavage ‎Human [1.3]

‐ Enterobacteriaceae Sputum ‎Human [1.6]

‐ Escherichia coli Faeces ‎Human [1.7]

‐ Eubacterium Bronchoalveolar lavage ‎Human [1.3]

‐ Faecalibacterium Bronchoalveolar lavage ‎Human [1.3]

‐ Flavonifractor Bronchoalveolar lavage ‎Human [1.3]

‐ Frigoribacterium Sputum ‎Human [1.1]

‐ Gallibacterium Bronchoalveolar lavage ‎Human [1.2]

‐ Gammaproteobacteria Sputum ‎Human [1.8]

‐ Gemella Swab throat ‎Human [1.9]

‐ Gemella Bronchoalveolar lavage ‎Human [1.2]

‐ Georgenia Sputum ‎Human [1.1]

‐ Glaciecola Sputum ‎Human [1.1]

‐ Granulicatella Sputum ‎Human [1.1]

‐ Granulicatella Bronchoalveolar lavage ‎Human [1.2]

‐ Haemophilus Nasopharyngeal aspirate ‎Human [1.10]

‐ Haemophilus Swab throat ‎Human [1.9]

‐ Helicobacter Sputum ‎Human [1.1]

‐ Klebsiella Bronchial brush ‎Human [1.11]

‐ Lactobacillus Faeces ‎Human [1.7]

‐ Lactobacillus Oropharynx swab ‎Human [1.12]

‐ Lactobacillus rhamnosus ‎Preventive

‐ Leclercia Bronchial brush ‎Human [1.11]

‐ Leucosporidium Bronchoalveolar lavage ‎Human [1.3]

‐ Moraxella Nasopharyngeal aspirate ‎Human [1.10]

‐ Moraxella Nasal swab ‎Human [1.13]

‐ Nitrosomonadaceae Bronchial brush ‎Human [1.5]

‐ Odoribacter Bronchoalveolar lavage ‎Human [1.3]

‐ Oribacterium Bronchoalveolar lavage ‎Human [1.2]

‐ Oscillibacter Bronchoalveolar lavage ‎Human [1.3]

‐ Oxalobacteraceae Bronchial brush ‎Human [1.5]

‐ Parabacteroides Bronchoalveolar lavage ‎Human [1.3]

‐ Planococcaceae Bronchoalveolar lavage ‎Human [1.2]

‐ Pneumocystis Bronchoalveolar lavage ‎Human [1.3]

‐ Proteobacteria Sputum ‎Human [1.8]

‐ Proteobacteria Nasopharyngeal swab ‎Human [1.14]

‐ Pseudomonadaceae Bronchial brush ‎Human [1.5]

‐ Pseudomonadaceae Sputum ‎Human [1.6]

‐ Pseudomonas Oropharynx swab ‎Human [1.12]

‐ Pyramidobacter Sputum ‎Human [1.1]

‐ Rhodosporidium Bronchoalveolar lavage ‎Human [1.3]

‐ Rhodotorula Bronchoalveolar lavage ‎Human [1.3]

‐ Romboutsia Bronchoalveolar lavage ‎Human [1.3]

‐ Roseburia Bronchoalveolar lavage ‎Human [1.3]

‐ Rothia Bronchoalveolar lavage ‎Human [1.2]

‐ Rothia Faeces ‎Human [1.4]

‐ Rothia Sputum ‎Human [1.1]

‐ Rubellimicrobium Sputum ‎Human [1.1]

‐ Ruminococcus Bronchoalveolar lavage ‎Human [1.3]

‐ Sarcandra Sputum ‎Human [1.1]

‐ Sphingomonadaceae Bronchial brush ‎Human [1.5]

‐ Stenotrophomonas Oropharynx swab ‎Human [1.12]

‐ Streptococcus Nasopharyngeal aspirate ‎Human [1.10]

‐ TM7 Bronchoalveolar lavage ‎Human [1.2]

‐ Veillonella Saliva ‎Human [1.15]

‐ Weeksella Bronchoalveolar lavage ‎Human [1.2]

Decreased abundance of

‐ Acinetobacter Sputum ‎Human [1.1]

‐ Actinobacillus Sputum ‎Human [1.1]

‐ Aggregatibacter Sputum ‎Human [1.1]

‐ Alicyclobacillus Sputum ‎Human [1.1]

‐ Alloiococcus Nasopharyngeal aspirate ‎Human [1.10]

‐ Anaerovorax Sputum ‎Human [1.1]

‐ Bifidobacterium Faeces ‎Human [1.16]

‐ Brevundimonas Sputum ‎Human [1.1]

‐ Bulleidia Sputum ‎Human [1.1]

‐ Butyrivibrio Sputum ‎Human [1.1]

‐ Capnocytophaga Bronchoalveolar lavage ‎Human [1.3]

‐ Catonella Sputum ‎Human [1.1]

‐ Corynebacterium Nasopharyngeal swab ‎Human [1.14]

‐ Corynebacterium Nasopharyngeal aspirate ‎Human [1.10]

‐ Cryptococcus Bronchoalveolar lavage ‎Human [1.3]

‐ Davidiella Bronchoalveolar lavage ‎Human [1.3]

‐ Deinococcus Sputum ‎Human [1.1]

‐ Dermabacter Sputum ‎Human [1.1]

‐ Desulfomicrobium Sputum ‎Human [1.1]

‐ Dialister Sputum ‎Human [1.1]

‐ Enterococcus Sputum ‎Human [1.1]

‐ Faecalibacterium Faeces ‎Human [1.17]

‐ Filifactor Sputum ‎Human [1.1]

‐ Fusobacterium Sputum ‎Human [1.1]

‐ Lachnospira Faeces ‎Human [1.4, 1.17]

‐ Lampropedia Sputum ‎Human [1.1]

‐ Leptotrichia Sputum ‎Human [1.1]

‐ Leuconostoc Sputum ‎Human [1.1]

‐ Moraxella Nasopharyngeal swab ‎Human [1.14]

‐ Moraxella Sputum ‎Human [1.1]

‐ Mycobacterium Sputum ‎Human [1.1]

‐ Mycoplana Sputum ‎Human [1.1]

‐ Neisseria Oropharynx swab ‎Human [1.12]

‐ Nevskia Sputum ‎Human [1.1]

‐ Oribacterium Sputum ‎Human [1.1]

‐ Paludibacter Sputum ‎Human [1.1]

‐ Parvimonas Sputum ‎Human [1.1]

‐ Peptococcus Sputum ‎Human [1.1]

‐ Phyllobacterium Sputum ‎Human [1.1]

‐ Porphyromonadaceae Sputum ‎Human [1.6]

‐ Prevotella Oropharynx swab ‎Human [1.12]

‐ Prevotella Sputum ‎Human [1.1]

‐ Prevotella Swab throat ‎Human [1.9]

‐ Proteus Bronchoalveolar lavage ‎Human [1.3]

‐ Rothia Faeces ‎Human [1.17]

‐ Sanguibacter Sputum ‎Human [1.1]

‐ Skermanella Sputum ‎Human [1.1]

‐ Slackia Sputum ‎Human [1.1]

‐ Sporosarcina Sputum ‎Human [1.1]

‐ Staphylococcus Nasopharyngeal aspirate ‎Human [1.10]

‐ Staphylococcus Sputum ‎Human [1.1]

‐ Sterigmatomyces Bronchoalveolar lavage ‎Human [1.3]

‐ Streptococcus Saliva ‎Human [1.15]

‐ Streptococcus Oropharynx swab ‎Human [1.12]

‐ Tannerella Sputum ‎Human [1.1]

‐ Treponema Sputum ‎Human [1.1]

‐ Veillonella Swab throat ‎Human [1.9]

‐ Veillonella Faeces ‎Human [1.17]

‐ Veillonella Oropharynx swab ‎Human [1.12]

‐ Virgibacillus Sputum ‎Human [1.1]

‐ Wolinella Sputum ‎Human [1.1]

‐ Yaniella Sputum ‎Human [1.1]

Asthma {40000140}

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Notes

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