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Asthma {40000140}

Record Keys


Definition:
Asthma
Class:[  ]

Details


Other Terms:[  ]
Initialisation date:
2020-09-06

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Meta Information


ICD:[  ]
Category:
Pulmonary
MedDra ID:
10003553
MedDra Level:
pt

Notes


[  ]

Shared Notes


  • [1.19
    - Differences in the fungal community were more strongly associated with asthma risk than bacterial dysbiosis.
    - Overrepresentation of total fungal sequences and an expansion of the yeast Issatchenkia orientalis in children who later developed symptoms
  • [1.20
    - Increased maternal dietary microbiome-accessible fiber and SCFA exposure during pregnancy > reduced incidence of asthma in offspring which persists into adulthood.
    - Reduced dietary fiber intake > reduced serum acetate levels in pregnant women > increased frequency of coughing/wheezing during the child’s first year of life.
    - During pregnancy > SCFA (such as acetate) > cross the placenta and affect the expression of fetal lung genes, such as NPPA, > encodes ANP (a molecule related to epithelial biology and immune regulation).
  • [1.21
    - Severe respiratory viral infection with respiratory syncytial virus (RSV) and rhinovirus (RV) is associated with increased risk of developing asthma, and as such, these viruses are considered asthmagenic.
    - Mice nasally exposed to two distinct strains of the commensal bacterial species Lactobacillus rhamnosus (LR05 and LR06) were protected against subsequent RSV infection.
    - Protection was associated with increased levels of IFN-β, IFN-γ, IL-6, and TNF-α in both BAL and serum samples, which contributed to viral clearance.


[Coverage other Diseases (Overlap > 0.25)]

DiseaseOverlapCommon increased OrganismCommon decreased Organism
Asthma 1.0000 57 (100%) : Acidaminococcus | Actinomyces | Adlercreutzia | Alistipes | Anaerostipes | Bacteroides | Cellulomonas | Clostridiaceae | Clostridium neonatale | Comamonadaceae | Eisenbergiella | Enterobacteriaceae | Escherichia coli | Eubacterium | Faecalibacterium | Flavonifractor | Frigoribacterium | Gallibacterium | Gammaproteobacteria | Gemella | Georgenia | Glaciecola | Granulicatella | Haemophilus | Helicobacter | Klebsiella | Lactobacillus | Lactobacillus rhamnosus | Leclercia | Leucosporidium | Moraxella | Nitrosomonadaceae | Odoribacter | Oribacterium | Oscillibacter | Oxalobacteraceae | Parabacteroides | Planococcaceae | Pneumocystis | Proteobacteria | Pseudomonadaceae | Pseudomonas | Pyramidobacter | Rhodosporidium | Rhodotorula | Romboutsia | Roseburia | Rothia | Rubellimicrobium | Ruminococcus | Sarcandra | Sphingomonadaceae | Stenotrophomonas | Streptococcus | TM7 | Veillonella | Weeksella 54 (100%) : Acinetobacter | Actinobacillus | Aggregatibacter | Alicyclobacillus | Alloiococcus | Anaerovorax | Bifidobacterium | Brevundimonas | Bulleidia | Butyrivibrio | Capnocytophaga | Catonella | Corynebacterium | Cryptococcus | Davidiella | Deinococcus | Dermabacter | Desulfomicrobium | Dialister | Enterococcus | Faecalibacterium | Filifactor | Fusobacterium | Lachnospira | Lampropedia | Leptotrichia | Leuconostoc | Moraxella | Mycobacterium | Mycoplana | Neisseria | Nevskia | Oribacterium | Paludibacter | Parvimonas | Peptococcus | Phyllobacterium | Porphyromonadaceae | Prevotella | Proteus | Rothia | Sanguibacter | Skermanella | Slackia | Sporosarcina | Staphylococcus | Sterigmatomyces | Streptococcus | Tannerella | Treponema | Veillonella | Virgibacillus | Wolinella | Yaniella
Colorectal cancer 0.2602 17 (30%) : Actinomyces | Bacteroides | Enterobacteriaceae | Escherichia coli | Eubacterium | Gemella | Granulicatella | Helicobacter | Klebsiella | Lactobacillus | Oscillibacter | Pseudomonas | Rhodotorula | Roseburia | Ruminococcus | Stenotrophomonas | Streptococcus 12 (22%) : Acinetobacter | Bifidobacterium | Brevundimonas | Dialister | Faecalibacterium | Lachnospira | Leptotrichia | Neisseria | Parvimonas | Prevotella | Staphylococcus | Streptococcus
Type 2 diabetes 0.2597 18 (32%) : Acidaminococcus | Actinomyces | Alistipes | Bacteroides | Escherichia coli | Eubacterium | Gemella | Haemophilus | Klebsiella | Lactobacillus | Lactobacillus rhamnosus | Parabacteroides | Pseudomonas | Roseburia | Rubellimicrobium | Stenotrophomonas | Streptococcus | Weeksella 11 (20%) : Acinetobacter | Aggregatibacter | Bifidobacterium | Faecalibacterium | Filifactor | Fusobacterium | Lachnospira | Neisseria | Prevotella | Staphylococcus | Streptococcus
Autism 0.2539 11 (19%) : Bacteroides | Enterobacteriaceae | Haemophilus | Lactobacillus | Odoribacter | Parabacteroides | Pseudomonas | Roseburia | Rothia | Ruminococcus | Streptococcus 17 (31%) : Bifidobacterium | Bulleidia | Butyrivibrio | Catonella | Corynebacterium | Dialister | Enterococcus | Fusobacterium | Oribacterium | Parvimonas | Peptococcus | Prevotella | Rothia | Streptococcus | Tannerella | Treponema | Veillonella
Obesity 0.2529 13 (23%) : Adlercreutzia | Alistipes | Bacteroides | Faecalibacterium | Gemella | Haemophilus | Lactobacillus | Parabacteroides | Proteobacteria | Pseudomonas | Romboutsia | Roseburia | Stenotrophomonas 15 (28%) : Acinetobacter | Anaerovorax | Bifidobacterium | Bulleidia | Capnocytophaga | Dialister | Faecalibacterium | Fusobacterium | Lachnospira | Leptotrichia | Paludibacter | Prevotella | Rothia | Streptococcus | Veillonella
Parkinson's Disease 0.2519 15 (26%) : Acidaminococcus | Alistipes | Bacteroides | Eisenbergiella | Enterobacteriaceae | Faecalibacterium | Klebsiella | Lactobacillus | Odoribacter | Parabacteroides | Proteobacteria | Roseburia | Ruminococcus | Streptococcus | Veillonella 13 (24%) : Brevundimonas | Bulleidia | Capnocytophaga | Corynebacterium | Faecalibacterium | Lachnospira | Leptotrichia | Mycoplana | Neisseria | Prevotella | Rothia | Streptococcus | Veillonella
Crohn's disease 0.2510 17 (30%) : Acidaminococcus | Actinomyces | Anaerostipes | Enterobacteriaceae | Escherichia coli | Haemophilus | Klebsiella | Lactobacillus | Odoribacter | Proteobacteria | Pseudomonas | Rothia | Ruminococcus | Stenotrophomonas | Streptococcus | TM7 | Veillonella 11 (20%) : Bifidobacterium | Dialister | Enterococcus | Faecalibacterium | Lachnospira | Mycobacterium | Neisseria | Paludibacter | Peptococcus | Prevotella | Streptococcus

Common References