Type 2 diabetes {40000105}
Definition: | Type 2 diabetes |
---|---|
Class: | [ ] |
Other Terms: | T2D, adult-onset diabetes |
---|---|
Authoring date: | 2020-09-06 |
ICD: | [ ] |
---|---|
Category: | [ ] |
MedDra ID: | 10067585 |
MedDra Level: | pt |
Notes
- Enterobacter cloacae B29 induced obesity and insulin resistance in germ-free mice. (3)
- PPI use is associated with reduced diversity of gut microbiome and consistent changes in the microbiota phenotype. (5)
- GIPR postbiotic agonist/antagonist may caus/prevent DM
Shared Notes
- [1.35]
- Akkermansia muciniphila is a mucin degraders, an important role in the preservation of the integrity of the gut mucus layer, thus
limiting the risk of systemic inflammation.
- Dietary polyphenols such as anthocyanins (ACNs) and proanthocyanidins (PACs) protect against metabolic syndrome.
- Supplementation of high-fat diets with ACNs or PACs has been shown to suppress the expression of genes involved in fatty acid and triacylglycerol synthesis, the regulation of lipogenesis and cholesterol biosynthesis, and the assembly of very low density
lipoproteins.
- ACNs and PACs have also been argued to stem the development of insulin resistance by increasing insulin signaling, glycogen accumulation and adiponectin secretion in the presence of free fatty acids.
A. muciniphila abundance has been linked to reduced weight gain, adiposity, insulin resistance, and/or inflammatory markers in many contexts, including during pregnancy. - [1.36]
- Faecalibacterium prausnitzii, an indicator of inflammation, shows a decreased abundance in diabetes and obese persons. - [1.37]
- Diabetes taking metformin had higher relative abundance of Akkermansia muciniphila, a microbiota known for mucin degradation, and several gut microbiota known for production of SCFAs, including Butyrivibrio, Bifidobacterium bifidum, Megasphaera, and an operational taxonomic unit of Prevotella. - [1.38]
- Duodenal hypercontractility observed during T2D leads to the genesis of aberrant signalling from the afferent nerves to the hypothalamus, contributing to systemic insulin resistance
- Enteric NO has the capacity to decrease duodenal contractions and restore the gut-brain axis, subsequently improving insulin sensitivity
- Prebiotic treatment (oligofructose) decreases duodenal hypercontractility by modulating ENS activity and an increase in the levels of an intestinal lipid, 12-hydroxyeicosatetraenoic acid (12-HETE).
- The mechanism of prebiotic action implies the presence of an enkephalin/mu-opioid receptor and proliferator-activated receptor γ signalling and a bioactive lipid, 12S-hydroxyeicosatetraenoic acid. - [1.33]
- Synbiotic yogurt-fed mice demonstrated lower fasting blood glucose (FBG) levels.
- The blood glucose rise during the meal tolerance test (MTT) is lower in the synbiotic yogurt-fed mice
- Insulin sensitivit in not impacted by Synbiotic yogurt-fed in mice.
- the abundances of fecal Proteobacteria and Enterobacteriacae correlate positively with FBG levels which increase the progression of diabetes in mice. - [1.39]
- Agonism of GIP receptor (GIPR) have glycemic effect. - [1.40]
- There is a significant correlation between gut microbiota dysbiosis and an elevated level of interleukin 6 (IL-6) in plasma samples of patients with type 2 diabetes (T2D) - [1.41]
- The feeding of the synbiotic yogurt significantly reduced the development of hyperglycemia (diabetes) in response to high-fat diet feeding and streptozotocin compared to milk-fed controls. - [1.42]
- The commonly used diabetes treatment Metformin increase Akkermansia spp. abundance, and to significantly improve glucose metabolism in high-fat diet fed mice while also increasing the number of mucin-producing goblet cells.
Common References
- [1.1] The gut microbial diversity of newly diagnosed diabetics but not prediabetics is significantly different from that of healthy nondiabetics [2020] [80001396] [mSystems] [Journal]
- [1.2] Dysbiosis of urinary microbiota is positively correlated with type 2 diabetes mellitus [2017] [80000429] [Oncotarget] [Journal]
- [1.3] Distribution and diversity of ocular microbial communities in diabetic patients compared with healthy subjects [2018] [80001161] [Current Eye Research] [Journal]
- [1.4] Understanding the gut-kidney axis among biopsy-proven diabetic nephropathy, type 2 diabetes mellitus and healthy controls: an analysis of the gut microbiota composition [2019] [80001227] [Acta Diabetologica] [Journal]
- [1.5] Oral microbiome signatures in diabetes mellitus and periodontal disease [2020] [80001350] [Journal of Dental Research] [Journal]
- [1.6] Subgingival microbiota of Mexicans with Type 2 diabetes with different periodontal and metabolic conditions [2019] [80001165] [International Journal of Environmental Research and Public Health] [Journal]
- [1.7] Association between blood microbiome and type 2 diabetes mellitus: a nested case-control study [2019] [80000931] [Journal of Clinical Laboratory Analysis] [Journal]
- [1.8] A metagenome-wide association study of gut microbiota in type 2 diabetes. [2012] [80000240] [Nature] [Journal]
- [1.9] Relationship between alterations of urinary microbiota and cultured negative lower urinary tract symptoms in female type 2 diabetes patients [2019] [80001099] [BMC Urology] [Journal]
- [1.10] How ocular surface microbiota debuts in type 2 diabetes mellitus [2019] [80001133] [Frontiers in Cellular and Infection Microbiology] [Journal]
- [1.11] Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics [2019] [80001084] [EBioMedicine] [Journal]
- [1.12] The oral microflora in obesity and type-2 diabetes [2012] [80000448] [Journal of Oral Microbiology] [Journal]
- [1.13] Quantitation and Composition of Cutaneous Microbiota in Diabetic and Nondiabetic Men [2013] [80000458] [Journal of Infectious Diseases] [Journal]
- [1.14] Gut metagenome in european women with normal, impaired and diabetic glucose control. [2013] [80000308] [Nature] [Journal]
- [1.15] Gut microbiome profiles are associated with type 2 diabetes in urban africans [2020] [80001362] [Frontiers in Cellular and Infection Microbiology] [Journal]
- [1.16] Whole metagenomic shotgun sequencing of the subgingival microbiome of diabetics and non-diabetics with different periodontal conditions [2019] [80001055] [Archives of Oral Biology] [Journal]
- [1.17] Implication of the gut microbiome composition of type 2 diabetic patients from northern China [2020] [80001348] [Scientific Reports] [Journal]
- [1.18] Prevalence of Epstein-Barr virus, human papillomavirus, cytomegalovirus and herpse simplex virus type 1 in patients with diabetes mellitus type 2 in south-eastern Poland [2019] [80001088] [PLOS ONE] [Journal]
- [1.19] Metagenomic analysis of duodenal microbiota reveals a potential biomarker of dysbiosis in the course of obesity and type 2 diabetes: a pilot study [2020] [80001381] [Journal of Clinical Medicine] [Journal]
- [1.20] The oral microbiome profile and biomarker in Chinese type 2 diabetes mellitus patients [2020] [80001313] [Endocrine] [Journal]
- [1.21] Gut dysbiosis and detection of "live gut bacteria" in blood of Japanese patients with type 2 diabetes [2014] [80000309] [Diabetes Care] [Journal]
- [1.22] The alteration of gut microbiota in newly diagnosed type 2 diabetic patients [2019] [80000922] [Nutrition] [Journal]
- [1.23] Comparison of gut microbiota in adult patients with type 2 diabetes and healthy controls [2017] [80001069] [Microbial Pathogenesis] [Journal]
- [1.24] Alterations in fecal Lactobacillus and Bifidobacterium species in type 2 diabetic patients in Southern China population [2013] [80000585] [Frontiers in Physiology] [Journal]
- [1.25] Gut microbial diversity assessment of Indian Type -2-diabetics reveals alterations in eubacteria, archaea, and eukaryotes. [2017] [80000442] [Frontiers in Microbiology] [Journal]
- [1.26] Investigation of the effect of Type 2 diabetes mellitus on subgingival plaque microbiota by high-throughput 16S rDNA pyrosequencing [2013] [80000790] [PLOS ONE] [Journal]
- [1.27] Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. [2010] [80000239] [PLOS ONE] [Journal]
- [1.28] Obese individuals with and without Type 2 diabetes show different gut microbial functional capacity and composition [2019] [80001082] [Cell Host & Microbe] [Journal]
- [1.29] Community analysis of chronic wound bacteria using 16S rRNA gene-based pyrosequencing: impact of diabetes and antibiotics on chronic wound microbiota. [2009] [80000367] [PLOS ONE] [Journal]
- [1.30] Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus [2019] [80001121] [Bioscience Reports] [Journal]
- [1.31] Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss [2010] [80001231] [Diabetes] [Journal]
- [1.32] An Almond-Based Low Carbohydrate Diet Improves Depression and Glycometabolism in Patients with Type 2 Diabetes through Modulating Gut Microbiota and GLP-1: A Randomized Controlled Trial [2020] [Research] [80001462] [Nutrients] [Journal]
- [1.33] A Newly Developed Synbiotic Yogurt Prevents Diabetes by Improving the Microbiome—Intestine—Pancreas Axis [2021] [Research] [80001647] [International journal of molecular sciences] [Journal]
- [1.34] Adherent-invasive E. coli metabolism of propanediol in Crohn’s disease regulates phagocytes to drive intestinal inflammation [2021] [Abstract] [80001646] [Cell Host & Microbe] [Journal]
- [1.35] The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism [2016] [Review] [80000001] [Nature Reviews Microbiology] [Journal]
- [1.36] Diet rapidly and reproducibly alters the human gut microbiome [2014] [Review] [80000056] [Nature] [Journal]
- [1.37] Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid-Producing Microbiota in the Gut [2017] [Research] [80001562] [Diabetes Care] [Journal]
- [1.38] Identification of new enterosynes using prebiotics: roles of bioactive lipids and mu-opioid receptor signalling in humans and mice [2021] [Research] [80001575] [Neurogastroenterology] [Journal]
- [1.39] The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling [2021] [Research] [80001649] [Cell Metabolism] [Journal]
- [1.40] The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases [2020] [Review] [80001677] [Gut microbes] [Journal]
- [1.41] A Newly Developed Synbiotic Yogurt Prevents Diabetes by Improving the Microbiome–Intestine–Pancreas Axis [2021] [Research] [80001711] [International journal of molecular sciences] [Journal]
- [1.42] Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice [2021] [Review] [80001781] [Scientific Reports] [Journal]