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Microbiome & Chronic Diseases

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Disease ⇒ Ischemic stroke {40000474}

Record Keys


Type:
Disease
Definition:
Ischemic stroke
Parent:[  ]

Details


Initialisation date:[  ]
Other Terms:
Stroke

Meta Information


MedDra ID:
10061256
MedDra Level:
pt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


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Shared Reference Notes


  • [1.1
    - A lack of SCFAs-producing bacteria and a low fecal SCFAs level defined dysbiosis in AIS patients, especially those with increased stroke severity. The SCFAs levels were negatively correlated with stroke severity and prognosis.
  • - Reduced SCFAs levels, especially acetate, were associated with an increased risk of 90-day poor functional stroke outcomes even after adjustments.
  • [1.5
    - Stroke increases the permeability of intestinal barriers , alters bacterial composition of the gut, causing gut dysbiosis and promotes seeding of gut bacteria within the lung, spleen, and liver . Such peripheral effects might exert additional effects on the damaged brain, thus hindering recovery.
  • [1.6
    - Innate and adaptive immune system plays a pivotal role in the evolution of cerebral injury, by actively participating in brain damage development on the one hand, and in tissue repair on the other .
    - The most known metabolite classes derived from the gut microbiota with immunomodulatory effects are: 1) amino acids and their derivatives; 2) products of microbial fermentation: short-chain fatty acids (SCFA) and polyphenols; 3) secondary bile acids; and 4) trimethylamines
  • [1.7
    - A lack of SCFAs-producing bacteria and a low fecal SCFAs level defined dysbiosis in AIS patients, especially those with increased stroke severity.
    -The SCFAs levels were negatively correlated with stroke severity and prognosis.
  • - Reduced SCFAs levels, especially acetate, were associated with an increased risk of 90-day poor functional outcomes even after adjustments.
  • [1.3
    - bacteria with capacity of butyrate production, Lachnospiraceae and Ruminococcaceae, were depleted in individuals at a high risk of stroke. Fecal butyrate concentrations also were low in these people
  • [1.8
    - SCFAs could promote recovery after stroke by acting on microglia to inhibit their activation