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- Subjects affected by primary headache have a H. pylori infection prevalence of 40%.
- It also found a higher prevalence of migraine without aura in infected patients.
- Higher IgM antibody titers against H. pylori in PWM compared to controls.
- A positive correlation between IgG antibody titers and severity of migraine.
- The serum levels of CGRP, which has been suggested as a biomarker for chronic migraine are also higher in those with H. pylori-associated duodenal ulcers compared with healthy controls.
- H. pyloriis exposed to fairly high concentrations of NO in gastric juice, which has low oxygen tension.
- NO directly inhibits the respiration of E. coli whereas it rapidly reacts with endogenously generated superoxide radicals in H. pylori. The resulting peroxynitrite inactivates the respiration of H. pylori.
- These results suggest that bacteria in the mouth may therefore contribute to efficient breakdown of nitrate contained in foods and food preservatives, which are finally converted into nitric oxide in the bloodstream, causing vessels in the brain and scalp to dilate.
Pseudomonas have the potential to reduce nitrate.
- Streptococcus and Pseudomonas, both of which have species with the potential to reduce nitrate.
- [1.1] Structural and functional characterization of the gut microbiota in elderly women with migraine   [Frontiers in Cellular and Infection Microbiology]
- [1.2] Helicobacter pylori Generates Superoxide Radicals and Modulates Nitric Oxide Metabolism  [Research]  [Journal of Biological Chemistry]
- [1.3] Gastrointestinal disorders associated with migraine: A comprehensive review  [Review]  [World journal of gastroenterology]
- [1.4] Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort  [Research]  [mSystems]