MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Irritable bowel syndrome {40000135}

Record Keys


Definition:
Irritable bowel syndrome
Class:[  ]

Details


Other Terms:
IBS
Authoring date:
2020-09-06

Links


Meta Information


ICD:[  ]
Category:
Gastroenterologic
MedDra ID:
10023003
MedDra Level:
pt

Notes


- Oral administration of Bifidobacterium infantis 35624 normalized sensitivity to colorectal distension in a rat model of post-inflammatory colonic hypersensitivity (1)

- The probiotic B. infantis 35624 reduced CRD-induced visceral pain behaviors in both rat strains. It significantly increased the threshold pressure of the first pain behavior and also reduced the total number pain behaviors during CRD (2)

- Purine metabolism is the novel host-microbial metabolic pathway in IBS (4)

Shared Notes


  • [1.24
    - Bifidobacterium infantis seems to be effective in human studies with IBS patients by changing plasma proinflammatory to anti-inflammatory cytokine ratio.
  • [1.23
    - Mice colonized with IBS+A microbiota developed faster gastrointestinal transit and anxiety‐like behavior (longer step‐down latency) compared to mice with HC microbiota.
    - Saccharomyces boulardii administration normalized gastrointestinal transit and anxiety‐like behavior in mice with IBS+A microbiota.

    Step‐down latency correlated with colonic Trpv1 expression and was associated with altered microbiota profile and increased Indole‐3‐acetic acid (IAA) levels.

Common References