Irritable bowel syndrome {40000135}

Record Keys
Definition:	Irritable bowel syndrome
Class:	[ ]

Details
Other Terms:	IBS
Authoring date:	2020-09-06

Links
Wickipedia Merck Manual

Meta Information
ICD:	[ ]
Category:	Gastroenterologic
MedDra ID:	10023003
MedDra Level:	pt

Notes

- Oral administration of Bifidobacterium infantis 35624 normalized sensitivity to colorectal distension in a rat model of post-inflammatory colonic hypersensitivity (1)

- The probiotic B. infantis 35624 reduced CRD-induced visceral pain behaviors in both rat strains. It significantly increased the threshold pressure of the first pain behavior and also reduced the total number pain behaviors during CRD (2)

- Purine metabolism is the novel host-microbial metabolic pathway in IBS (4)

Shared Notes

[1.24]
- Bifidobacterium infantis seems to be effective in human studies with IBS patients by changing plasma proinflammatory to anti-inflammatory cytokine ratio.
[1.23]
- Mice colonized with IBS+A microbiota developed faster gastrointestinal transit and anxiety‐like behavior (longer step‐down latency) compared to mice with HC microbiota.
- Saccharomyces boulardii administration normalized gastrointestinal transit and anxiety‐like behavior in mice with IBS+A microbiota.

Step‐down latency correlated with colonic Trpv1 expression and was associated with altered microbiota profile and increased Indole‐3‐acetic acid (IAA) levels.

Common References

[1.1] Structural alterations of faecal and mucosa-associated bacterial communities in irritable bowel syndrome [2012] [80000629] [Environmental Microbiology Reports]
[1.2] Dysbiosis of fecal microbiota and high frequency of Citrobacter, Klebsiella spp., and Actinomycetes in patients with irritable bowel syndrome and gastroenteritis [2016] [80000589] [Gastroenterology and Hepatology]
[1.3] An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota [2012] [80000591] [Gut]
[1.4] Molecular assessment of differences in the duodenal microbiome in subjects with irritable bowel syndrome [2015] [80000415] [Scand J Gastroenterol]
[1.5] Gut microbiota dysbiosis in children with relapsing idiopathic nephrotic syndrome [2018] [80000692] [American Journal of Nephrology]
[1.6] The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects [2007] [80001076] [Gastroenterology]
[1.7] Intestinal fungal dysbiosis is associated with visceral hypersensitivity in patients with irritable bowel syndrome and rats [2017] [80001060] [Gastroenterology]
[1.8] Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. [2011] [80000294] [Gastroenterology]
[1.9] Fecal microbiota in patients with irritable bowel syndrome compared with healthy controls using real-time polymerase chain reaction: an evidence of dysbiosis. [2015] [80000236] [Digestive Diseases and Sciences]
[1.10] Characteristic dysbiosis of gut microbiota of Chinese patients with diarrhea-predominant irritable bowel syndrome by an insight into the pan-microbiome [2019] [80001123] [Chinese Medical Journal]
[1.11] Evidence of altered mucosa-associated and fecal microbiota composition in patients with irritable bowel syndrome [2020] [80001337] [Scientific Reports]
[1.12] Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome [2011] [80000291] [Gastroenterology]
[1.13] Fecal and Mucosa-associated intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome [2018] [80000864] [Digestive Diseases and Sciences]
[1.14] Quantitative profiling of gut microbiota of children with diarrhea-predominant irritable bowel syndrom [2012] [80000293] [The American Journal of Gastroenterology]
[1.15] Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome [2012] [80000623] [Alimentary Pharmacology and Therapeutics]
[1.16] Mucosal microbiome profiles polygenic irritable bowel syndrome in Mestizo individuals [2020] [80001366] [Frontiers in Cellular and Infection Microbiology]
[1.17] Fecal and mucosal microbiota profiling in irritable bowel syndrome and inflammatory bowel disease [2019] [80001146] [Frontiers in Microbiology]
[1.18] Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome [2017] [80000467] [Microbiome]
[1.19] Molecular characterization of the intestinal microbiota in patients with and without abdominal bloating [2016] [80000352] [American journal of physiology. Gastrointestinal and liver physiology]
[1.20] Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome_DUBLICATE [2018] [80000965] [Science translational medicine]
[1.21] Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients_DUBLICATE [2009] [80001228] [World journal of gastroenterology]
[1.22] Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR [2005] [80000290] [American Journal of Gastroenterology]
[1.23] Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Syndrome [2020] [Research] [80001673] [Neurogastroenterology & Motility]
[1.24] The Microbiota and Gut-Brain Axis [2016] [Report] [80000021] [Journal of Mood Disorders]

Increased abundance of

‐ Acinetobacter Faeces ‎Human [1.1]

‐ Actinomyces Faeces ‎Human [1.2, 1.3]

‐ Aeromonas Duodenal aspirate ‎Human [1.4]

‐ Alcaligenaceae Faeces ‎Human [1.5]

‐ Alistipes Faeces ‎Human [1.1]

‐ Allisonella Faeces ‎Human [1.6]

‐ Alternaria alternata Faeces ‎Human [1.7]

‐ Anaerovorax Faeces ‎Human [1.8]

‐ Aneurinibacillus Faeces ‎Human [1.8]

‐ Bacteroides Tissue biopsie ‎Human [1.1]

‐ Bacteroides Faeces ‎Human [1.6, 1.9, 1.10]

‐ Bifidobacterium Faeces ‎Human [1.3]

‐ Bifidobacterium infantis ‎Ameliorative ‎Gut Lumen ‎Mouse

‐ Blautia Faeces ‎Human [1.3, 1.8]

‐ Butyricimonas Faeces ‎Human [1.1, 1.1]

‐ Candida solani Faeces ‎Human [1.7]

‐ Candida tropicalis Faeces ‎Human [1.7]

‐ Candidatus saccharibacteria bacterium Faeces ‎Human [1.11]

‐ Candidatus soleaferrea Tissue biopsie ‎Human [1.11]

‐ Candidatus soleaferrea Faeces ‎Human [1.11]

‐ Citrobacter Faeces ‎Human [1.2]

‐ Clostridioides difficile Faeces ‎Human [1.8]

‐ Clostridium leptum Faeces ‎Human [1.8]

‐ Clostridium symbiosum Faeces ‎Human [1.8]

‐ Collinsella Faeces ‎Human [1.6]

‐ Coprococcus eutactus Faeces ‎Human [1.8]

‐ Dialister Faeces ‎Human [1.3, 1.5, 1.8]

‐ Dorea Faeces ‎Human [1.3, 1.8, 1.12, 1.13]

‐ Enterobacter Faeces ‎Human [1.14]

‐ Enterobacteriaceae Faeces ‎Human [1.15]

‐ Enterococcus Tissue biopsie ‎Human [1.16]

‐ Erysipelotrichia Faeces ‎Human [1.17]

‐ Escherichia Faeces ‎Human [1.3]

‐ Escherichia coli Duodenal aspirate ‎Human [1.4]

‐ Escherichia coli Faeces ‎Human [1.2]

‐ Eubacterium ventriosum Faeces ‎Human [1.11]

‐ Faecalibacterium prausnitzii Faeces ‎Human [1.5]

‐ Faecalitalea Tissue biopsie ‎Human [1.11]

‐ Flavonifractor plautii Faeces ‎Human [1.8]

‐ Haemophilus parainfluenzae Faeces ‎Human [1.12]

‐ Holdemania Faeces ‎Human [1.18]

‐ Kazachstania turicensis Faeces ‎Human [1.7]

‐ Klebsiella Faeces ‎Human [1.2]

‐ Klebsiella Duodenal aspirate ‎Human [1.4]

‐ Lachnoclostridium Faeces ‎Human [1.11]

‐ Lachnoclostridium Tissue biopsie ‎Human [1.11]

‐ Lachnospira Faeces ‎Human [1.8]

‐ Lactobacillales Faeces ‎Human [1.18]

‐ Lactobacillus Faeces ‎Human [1.2, 1.19]

‐ Leuconostoc Faeces ‎Human [1.1]

‐ Marvinbryantia Faeces ‎Human [1.8]

‐ Monographella nivalis Faeces ‎Human [1.7]

‐ Odoribacter Faeces ‎Human [1.1]

‐ Oxalobacter Faeces ‎Human [1.14]

‐ Papillibacter Faeces ‎Human [1.3, 1.8]

‐ Paraprevotella Faeces ‎Human [1.10]

‐ Parasporobacterium Faeces ‎Human [1.14]

‐ Peptococcus Faeces ‎Human [1.8]

‐ Prevotella Faeces ‎Human [1.10]

‐ Prevotellaceae Tissue biopsie ‎Human [1.11]

‐ Propionibacterium Tissue biopsie ‎Human [1.16]

‐ Pseudomonas aeruginosa Faeces ‎Human [1.9]

‐ Raoultella Faeces ‎Human [1.14]

‐ Roseburia Faeces ‎Human [1.8]

‐ Ruminococcus gnavus Faeces ‎Human [1.8]

‐ Ruminococcus lactaris Faeces ‎Human [1.8]

‐ Ruminococcus productus Faeces ‎Human [1.9]

‐ Sporobacter Faeces ‎Human [1.3]

‐ Staphylococcus Tissue biopsie ‎Human [1.16]

‐ Streptococcus Faeces ‎Human [1.19, 1.20]

‐ Streptococcus intermedius Faeces ‎Human [1.8]

‐ Tyzzerella nexilis Faeces ‎Human [1.8]

‐ Veillonella Faeces ‎Human [1.9, 1.12]

‐ Veillonellaceae Faeces ‎Human [1.5]

Decreased abundance of

‐ Acinetobacter Duodenal aspirate ‎Human [1.4]

‐ Alistipes Faeces ‎Human [1.3, 1.8]

‐ Anaerostipes Faeces ‎Human [1.17]

‐ Anaerovorax Faeces ‎Human [1.12]

‐ Bacteriodes uniformis Faeces ‎Human [1.8]

‐ Bacteroidales Faeces ‎Human [1.18]

‐ Bacteroides Faeces ‎Human [1.3]

‐ Bacteroides Tissue biopsie ‎Human [1.16]

‐ Bacteroides fragilis Faeces ‎Human [1.8]

‐ Bacteroides intestinalis Faeces ‎Human [1.8]

‐ Bacteroides ovatus Faeces ‎Human [1.8]

‐ Bacteroides plebeius Faeces ‎Human [1.8]

‐ Bacteroides stercoris Faeces ‎Human [1.8]

‐ Bacteroides vulgatus Faeces ‎Human [1.8, 1.12]

‐ Bifidobacterium Faeces ‎Human [1.8, 1.9, 1.15, 1.21]

‐ Bifidobacterium catenulatum Faeces ‎Human [1.21, 1.22]

‐ Bifidobacterium catenulatum Brush sample ‎Human [1.21]

‐ Blautia Faeces ‎Human [1.10]

‐ Blautia coccoides Faeces ‎Human [1.22]

‐ Brevundimonas Tissue biopsie ‎Human [1.1]

‐ Butyricicoccus Tissue biopsie ‎Human [1.1]

‐ Christensenellaceae Tissue biopsie ‎Human [1.11]

‐ Citrobacter Duodenal aspirate ‎Human [1.4]

‐ Clostridium cocleatum Faeces ‎Human [1.6]

‐ Clostridium lituseburense Faeces ‎Human [1.21]

‐ Collinsella aerofaciens Faeces ‎Human [1.6]

‐ Coprococcus Tissue biopsie ‎Human [1.1, 1.11]

‐ Coprococcus Faeces ‎Human [1.10]

‐ Coprococcus eutactus Faeces ‎Human [1.6]

‐ Davidiella tassiana Faeces ‎Human [1.7]

‐ Dehalobacter Faeces ‎Human [1.14]

‐ Desulfovibrio Tissue biopsie ‎Human [1.1]

‐ Dorea Tissue biopsie ‎Human [1.16]

‐ Eubacterium Tissue biopsie ‎Human [1.1]

‐ Eubacterium Faeces ‎Human [1.12]

‐ Faecalibacterium Faeces ‎Human [1.10, 1.13]

‐ Faecalibacterium Tissue biopsie ‎Human [1.16]

‐ Fusibacter Faeces ‎Human [1.14]

‐ Fusobacterium Tissue biopsie ‎Human [1.1]

‐ Gemella Tissue biopsie ‎Human [1.16]

‐ Haemophilus Tissue biopsie ‎Human [1.1]

‐ Kazachstania telluris Faeces ‎Human [1.7]

‐ Lachnospira Tissue biopsie ‎Human [1.11]

‐ Lachnospiraceae Faeces ‎Human [1.19]

‐ Lachnospiraceae incertae sedis Faeces ‎Human [1.10]

‐ Lactobacillus Faeces ‎Human [1.6, 1.15]

‐ Microvirgula Duodenal aspirate ‎Human [1.4]

‐ Neisseria Tissue biopsie ‎Human [1.1]

‐ Odoribacter Tissue biopsie ‎Human [1.1]

‐ Odoribacter Faeces ‎Human [1.3, 1.8]

‐ Oribacterium Tissue biopsie ‎Human [1.1]

‐ Oscillibacter Tissue biopsie ‎Human [1.11]

‐ Oxobacter Faeces ‎Human [1.14]

‐ Parabacteroides Faeces ‎Human [1.8, 1.18]

‐ Penicillium spinulosum Faeces ‎Human [1.7]

‐ Porphyromonadaceae Faeces ‎Human [1.5]

‐ Prevotella oralis Faeces ‎Human [1.8]

‐ Prevotella ruminicola Faeces ‎Human [1.8]

‐ Prevotella tannerae Faeces ‎Human [1.8]

‐ Prevotellaceae Faeces ‎Human [1.5]

‐ Roseburia Faeces ‎Human [1.19]

‐ Ruminococcaceae Faeces ‎Human [1.5, 1.17]

‐ Staphylococcus Tissue biopsie ‎Human [1.11]

‐ Streptococcus Tissue biopsie ‎Human [1.1]

‐ Tannerella Faeces ‎Human [1.8]

‐ Veillonella Tissue biopsie ‎Human [1.1]

‐ Vishniacozyma victoriae Faeces ‎Human [1.7]

‐ Vivictivallis Tissue biopsie ‎Human [1.11]

Irritable bowel syndrome {40000135}

Record Keys

Details

Links

Meta Information

Notes

Shared Notes

Common References