MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Cancer {40000133}

Record Keys


Definition:
Cancer
Class:[  ]

Details


Other Terms:[  ]
Authoring date:
2020-09-06

Links


Meta Information


ICD:[  ]
Category:
Oncologic
MedDra ID:[  ]
MedDra Level:[  ]

Notes


- Bifidobacterium is associated with antitumor effects, and oral administration of Bifidobacterium alone improved tumor control to the same degree as PD-L1 antibody therapy while combination treatment nearly abolished tumor growth in mice. (1)

Shared Notes


  • [1.1
    - Smectite clay promotes lactic acid bacteria (LABs) to form biofilms on its surface
    - Smectite with LABs inhibits tumor growth in mice
    - Smectite with LABs enhances anti-cancer chemo/immunotherapy in mice
    - Smectite with LABs activates dendritic cells via TLR2 signaling
  • [1.2
    - The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of monoamine neurotransmitters, the generation of nitric oxide, and pain.
    - Administration of BH4 to mice markedly reduces tumour growth and expands the population of intratumoral effector T cells.
  • - Kynurenine—a tryptophan metabolite that blocks antitumour immunity—inhibits T cell proliferation in a manner that can be rescued by BH4.

Common References