Type 1 diabetes {40000104}
Definition: | Type 1 diabetes |
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Class: | [ ] |
Other Terms: | T1D, juvenile diabetes |
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Authoring date: | 2020-09-06 |
ICD: | [ ] |
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Category: | Endocrinologic |
MedDra ID: | 10067584 |
MedDra Level: | pt |
Notes
- Our study suggests that E. coli biofilm-derived highly immunogenic amyloid curly-DNA complexes might be involved in the activation of a pro-diabetic pathway in children who are at risk of T1D. (3)
Shared Notes
- [1.19]
- The protein expressed by the bacteria is almost identical to a protein expressed by insulin-producing cells in the pancreas. The CD8 lymphocytes can mistakenly attack the pancreatic cells and cause type 1 diabetes. - [1.20]
- One highly abundant group composed of two closely related species, Bacteroides dorei and Bacteroides vulgatus, was significantly higher in cases compared to controls prior to seroconversion. Metagenomic sequencing of samples high in the abundance of the B. dorei/vulgatus group before seroconversion, as well as longer 16S rRNA sequencing identified this group as Bacteroides dorei. The abundance of B. dorei peaked at 7.6 months in cases, over 8 months prior to the appearance of the first islet autoantibody, suggesting that early changes in the microbiome may be useful for predicting T1D autoimmunity in genetically susceptible infants. - [1.12]
- In patients with type 1 diabetes, elevated Blautia abundance was observed and was correlated with increased IA-2 tyrosine phosphatase autoantibodies, important markers of autoimmunity.
Common References
- [1.1] The human gut microbiome in early-onset type 1 diabetes from the TEDDY study [2018] [80000810] [Nature] [Journal]
- [1.2] Toward defining the autoimmune microbiome for type 1 diabetes [2011] [80000310] [The ISME Journal] [Journal]
- [1.3] Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study [2013] [80000311] [BMC Medicine] [Journal]
- [1.4] Fecal microbiota composition differs between children with β-cell autoimmunity and those without. [2013] [80000603] [Diabetes] [Journal]
- [1.5] Gut microbiota differs in composition and functionality between children with type 1 diabetes and MODY2 and healthy control subjects: a case-control study [2018] [80000812] [Diabetes Care] [Journal]
- [1.6] Fecal microbiota imbalance in Mexican children with type 1 diabetes [2014] [80000889] [Scientific Reports] [Journal]
- [1.7] Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes_DUBLICATE [2014] [80000845] [Frontiers in Microbiology] [Journal]
- [1.8] Differences in the gut microbiota of healthy children and those with type 1 diabetes [2014] [80000885] [Pediatrics International] [Journal]
- [1.9] Association between intestinal permeability and faecal microbiota composition in Italian children with betal cell autoimmunity at risk for type 1 diabetes [2016] [80000865] [Diabetes/Metabolism Research and Reviews] [Journal]
- [1.10] Imbalance of fecal microbiota at newly diagnosed type 1 diabetes in chinese children [2016] [80000417] [Chinese Medical Journal] [Journal]
- [1.11] Imbalance of fecal microbiota at newly diagnosed Type 1 diabetes in Chinese children_DUBLICATE [2016] [80000839] [Chinese Medical Journal] [Journal]
- [1.12] A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients [2021] [Research] [80001737] [mBio] [Journal]
- [1.13] Fungal dysbiosis and intestinal inflammation in children with beta-cell autoimmunity [2020] [80001368] [Frontiers in Immunology] [Journal]
- [1.14] Duodenal mucosa of patients with type 1 diabetes shows distinctive inflammatory profile and microbiota [2017] [80000520] [The Journal of Clinical Endocrinology & Metabolism] [Journal]
- [1.15] Aberrant gut microbiota composition at the onset of type 1 diabetes in young children [2014] [80000849] [Diabetologia] [Journal]
- [1.16] Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes. [2015] [80000838] [Diabetes] [Journal]
- [1.17] Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus [2019] [80001121] [Bioscience Reports] [Journal]
- [1.18] Intestinal virome changes precede autoimmunity in type 1 diabetes-susceptible children [2017] [80001202] [PNAS] [Journal]
- [1.19] A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis [2017] [Research] [80000054] [Cell] [Journal]
- [1.20] Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes [2014] [Research] [80000091] [Frontiers in Microbiology] [Journal]