Microbiome & Chronic Diseases

Evidence Based Medicine
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Type 1 diabetes {40000104}

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Type 1 diabetes
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Other Terms:
T1D, juvenile diabetes
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- Our study suggests that E. coli biofilm-derived highly immunogenic amyloid curly-DNA complexes might be involved in the activation of a pro-diabetic pathway in children who are at risk of T1D. (3)

Shared Notes

  • [1.18
    - In patients with type 1 diabetes, elevated Blautia abundance was observed and was correlated with increased IA-2 tyrosine phosphatase autoantibodies, important markers of autoimmunity.
  • [1.14
    - A study performed in Finnish children found a higher abundance of Bacteriodetes dorei prior to auto-immunity and T1D development.
    -The Bacteriodetes phyla produce lipopolysaccharide (LPS), a potent activator of the innate immune system, that in turn increases the auto-immune response in T1D in NOD mice
  • [1.24
    - Type 1 diabetes in children > higher relative abundance of the following most important taxa: Bacteroides stercoris, Bacteroides fragilis, Bacteroides intestinalis, Bifidobacterium bifidum, Gammaproteobacteria and its descendants, Holdemania, and Synergistetes and its descendants.
    - Type 1 diabetes in children > lower relative abundance of Bacteroides vulgatus, Deltaproteobacteria and its descendants, Parasutterella and the Lactobacillus, Turicibacter genera.
    The predicted metabolic pathway more associated with type 1 diabetes patients concerns “carbon metabolism,” sugar and iron metabolisms in particular.
    - Standardized body mass index, anti-insulin autoantibodies, glycemia, hemoglobin A1c, Tanner stage, and age at onset emerged as most significant positively or negatively correlated with specific clusters of taxa.
  • [1.25
    - The protein expressed by the bacteria is almost identical to a protein expressed by insulin-producing cells in the pancreas. The CD8 lymphocytes can mistakenly attack the pancreatic cells and cause type 1 diabetes.
  • [1.26
    - One highly abundant group composed of two closely related species, Bacteroides dorei and Bacteroides vulgatus, was significantly higher in cases compared to controls prior to seroconversion. Metagenomic sequencing of samples high in the abundance of the B. dorei/vulgatus group before seroconversion, as well as longer 16S rRNA sequencing identified this group as Bacteroides dorei. The abundance of B. dorei peaked at 7.6 months in cases, over 8 months prior to the appearance of the first islet autoantibody, suggesting that early changes in the microbiome may be useful for predicting T1D autoimmunity in genetically susceptible infants.

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