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Breast cancer ⇒ Cancer {40000376}

Record Keys


Definition:
Breast cancer
Class:

Details


Other Terms:[  ]
Initialisation date:[  ]

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ICD:[  ]
Category:[  ]
MedDra ID:
10006187
MedDra Level:
pt

Notes


[  ]

Shared Notes


  • [1.8
    - Cadaverine as a biogenic amine is formed through the direct decarboxylation of L-lysine.
    - It is reported that cadaverine biosynthesis is reduced in the gut in early-stage BC, resulting in lower production of an anti-cancer bacterial metabolite and reduced BC invasion
  • - Lithocholic acid can inhibit BC progression, epithelial-mesenchymal transition, and metastasis via activation of nuclear factor erythroid 2-related factor 2 (NRF2) and other proteins involved in the antioxidant defense system.
  • - Propionate, acetate, and butyrate are the three most predominant SCFAs and are well-known modulators for cell invasion and apoptosis in BC
  • - The abundance of Akkermansia muciniphila, as a key player of propionate production, is associated with the richness of the gut microbiota in patients with BC
  • - Intestinal bacteria can turn some plant lignans such as flaxseed, sunflower, caraway, pumpkin, legumes, and soybean, into mammalian lignans with protective effects against BC.
    - High consumption of raw vegetables showed a significant protective effect against BC risk.
  • - Enterolactone may act as a selective modulator of estrogen signaling and may be associated with lowering the risk of BC.
  • - Overuse of antibiotics might reduce the plasma level of lignan enterolactone; therefore, it might directly affect the microbiome populations and increase the BC risk
  • - Estrobolome, the bacterial gene mass in the human intestine, the products of which take part in estrogens metabolism, may increase the risk of estrogen receptor-positive BC in postmenopausal females.
    - Changes in gut microbiome composition may lead to the estrogen metabolism alternation and affect the BC risk.
  • - The proportions of Blautia and F. Prausnitzii and absolute numbers of Blautia and Bifidobacterium species in the gut microbiome are directly correlated with the clinical stage of BC.
    - For instance, patients with stage 1 BC had a lower number of gut Blautia sp. in comparison with the ones with stage grade 3
  • [1.9
    - Antibiotic-induced perturbation of the gut microbiota > increases tumor progression in multiple BrCa mouse models > increased number of cells with a stromal signature in tumors > increased abundance of mast cells in the tumor stromal regions.
    - Re-supplementation of antibiotic-treated mice with Faecalibaculum rodentium > restored tumor growth to control levels
    - Mast cell stabilizer, cromolyn > decreases tumor growth only in antibiotic treated animals
  • [1.11
    - Fucoidan > increasing the diversity of the intestinal flora composition and increasing the Bacteroidetes/Firmicutes phylum ratio > can restore intestinal wall damage in mice > prevent the occurrence of breast cancer
  • - H2S at a safe and nontoxic concentration can protect not only healthy cells, such as neurons, but also cancerous cells from apoptosis.
    - In a variety of cancers, including ovarian cancer, oral cancer, thyroid cancer, colon cancer, breast cancer, etc., the upregulation of H2S-producing enzyme CBS > can enhance the proliferation ability of cancer cells and make cancer cells more sensitive to it


[Coverage other Diseases (Overlap > 0.25)]

DiseaseOverlapCommon increased OrganismCommon decreased Organism
Breast cancer 1.0000 27 (100%) : Actinomyces | Alcaligenaceae | Alistipes | Atopobium | Bacillus | Bacillus alcalophilus | Bacteroidetes | Brachybacterium muris | Caulobacteriaceae | Comamonadaceae | Corynebacterium | Enterobacteriaceae | Fusobacterium | Gluconacetobacter | Hydrogenophaga | Lactobacillus rossiae | Methylobacteriaceae | Methylobacterium radiotolerans | Micrococcaceae | Mycobacterium fortuitum | Mycobacterium phlei | Nocardioidaceae | Propionibacteriaceae | Propionicimonas | Rhodobacteraceae | Salmonella enterica | Staphylococcus 15 (100%) : Acinetobacter baumannii | Acinetobacter radioresistens | Clostridiales | Corynebacterium | Escherichia coli | Lactococcus | Methylobacterium | Microbacterium barkeri | Micrococcus | Prevotella | Ralstonia pickettii | Sphingobium yanoikuyae | Sphingomonadaceae | Streptococcus | Veillonella

Common References