Gout {40000127}
| Definition: | Gout |
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| Class: | [ ] |
| Other Terms: | Podagra arthritis uric acid Hyperuricemia |
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| Authoring date: | 2020-09-06 |
| ICD: | [ ] |
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| Category: | Rheumatologic |
| MedDra ID: | [ ] |
| MedDra Level: | [ ] |
Notes
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Shared Notes
- [1.1]
- In gout, Bacteroides caccae and Bacteroides xylanisolvens are enriched.
- Faecalibacterium prausnitzii and Bifidobacterium pseudocatenulatum depleted.
- The established reference microbial gene catalogue for gout revealed disorder in purine degradation and butyric acid biosynthesis in gout patients.
- Intestinal microbiota of gout are more similar to those of type-2 diabetes than to liver cirrhosis, whereas depletion of Faecalibacterium prausnitzii and reduced butyrate biosynthesis are shared in each of the metabolic syndromes.
- Bacteroides caccae is one biomarker of IBD. OmpW protein produced by B. caccae is a target of the IBD-associated immune response, thus the enriched intestinal B. caccae in gout patients could potentially induce serious inflammatory response.
- Faecalibacterium prausnitzii has anti-inflammatory properties and contribute to gut health through butyrate production. for gout patients, potentially explaining the decline in butyric acid biosynthesis in gout patients.
Common References
- [1.1] Intestinal Microbiota Distinguish Gout Patients from Healthy Humans [2016] [Research] [80000012] [Scientific Reports]