MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Gout {40000127}

Record Keys
Definition:
Gout
Class:[  ]

Details
Other Terms:
Podagra arthritis uric acid Hyperuricemia
Initialisation date:
2020-09-06

Links

Meta Information
ICD:[  ]
Category:
Rheumatology
MedDra ID:[  ]
MedDra Level:[  ]

Notes

[  ]

Shared Notes

  • [1.1] 
    - In gout, Bacteroides caccae and Bacteroides xylanisolvens are enriched.
    - Faecalibacterium prausnitzii and Bifidobacterium pseudocatenulatum depleted.
    - The established reference microbial gene catalogue for gout revealed disorder in purine degradation and butyric acid biosynthesis in gout patients.
    - Intestinal microbiota of gout are more similar to those of type-2 diabetes than to liver cirrhosis, whereas depletion of Faecalibacterium prausnitzii and reduced butyrate biosynthesis are shared in each of the metabolic syndromes.
    - Bacteroides caccae is one biomarker of IBD. OmpW protein produced by B. caccae is a target of the IBD-associated immune response, thus the enriched intestinal B. caccae in gout patients could potentially induce serious inflammatory response.
    - Faecalibacterium prausnitzii has anti-inflammatory properties and contribute to gut health through butyrate production. for gout patients, potentially explaining the decline in butyric acid biosynthesis in gout patients.

Common References