Colorectal cancer ⇒ Cancer {40000123}
Definition: | Colorectal cancer |
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Class: |
Other Terms: | CRC |
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Authoring date: | 2019-05-15 |
ICD: | [ ] |
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Category: | Gastroenterologic, Oncologic |
MedDra ID: | 10061451 |
MedDra Level: | pt |
Notes
- The microbiomes of colorectal cancer subjects have increased abundance of a module for naphthalene degradation (M00534).
- The modules for cobalt/nickel transport systems (M00245 and M00246) are depleted in subjects with colorectal cancer.
- Enterotoxigenic Bacteroides fragilis (ETBF) secretes Bacteroides fragilis toxin (BFT), which decreases E-cadherin levels. This loosens the attachments between intestinal epithelial cells and results in exposure to many antigens. Moreover, decreased E-cadherin promotes intracellular migration of beta-catenin and accelerates carcinogenic-related signaling such as Wnt signaling. (1)
- Ren is a potential agent for colon cancer prevention.
- Administration of Ren effectively suppress DMH-induced colonic carcinogenesis. (4)
Shared Notes
- [1.42]
- Fusobacterium nucleatum is enriched in human colonic adenomas relative to surrounding tissue, suggesting that it may play a role in early initiation of colorectal cancer.
- Further supporting this idea, F. nucleatum colonization promoted and exacerbated tumorigenesis in the gut of APCmin/+ mice, although the mechanism of pathogenesis remains unknown. - [1.43]
- Studies have demonstrated an enrichment of Fusobacterium nucleatum in human colorectal adenomas and carcinomas compared to adjacent normal tissue.
- Experimental studies have shown that Fusobacterium nucleatum activates the WNT signaling pathway in colorectal carcinoma cells and may promote colorectal tumour growth
- a higher amount of tissue Fusobacterium nucleatum DNA has been associated with advanced disease stage and a lower density of T-cells in human colorectal carcinoma tissue. - [1.44]
- Fusobacterium nucleatum subsp. vincentii, F. nucleatum subsp. animalis, Porphyromonas asaccharolytica, and Peptostreptococcus stomatis, all of which were found to be enriched in tumor and stool samples from CRC patients.
- Patients with Peptostreptococcus bacteremia have an increased risk of developing , in particular Peptostreptococcus stomatis and Peptostreptococcus anaerobius. P. anaerobius has been found to be highly enriched in CRC patient stool and tissue.
- Significant overabundance of P. gingivalis was found in fecal samples from CRC patients
- Prevotella intermedia was associated with a higher risk of developing CRC and was identified in a multinational multicohort study of 526 metagenomic CRC fecal samples.
- Overabundance of Parvimonas micra has been reported in CRC patient stool.
Enterotoxigenic Bacteroides fragilis strains (ETBF) have been associated with CRC and is associated with sporadic CRC.
- Tissues of patients with familial adenomatous polyposis (FAP) carry B. fragilis and Escherichia coli biofilms.
-The genotoxin colibactin is produced by polyketide synthase-positive E. coli and induces DNA double-strand breaks in vitro and in vivo. It increases tumor formation in vitro alone, or in co-colonization with ETBF in FAP patients.
- B. fragilis and some Prevotellaceae, but also F. nucleatum, produce succinate, an inducer of proinflammatory pathways via succinate receptor 1 on immune cells .
- E. coli catabolism of lysine to succinate involves the intermediate l-2-hydroxyglutarate, an oncometabolite that is involved in epigenetic deregulation in certain cancers.
Common References
- [1.1] Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. [2013] [80000297] [PLOS ONE]
- [1.2] Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans. [2012] [80000304] [The ISME Journal]
- [1.3] Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer [2019] [80000928] [Gut]
- [1.4] Metagenomic analyses of the gut microbiota associated with colorectal adenoma [2019] [80001024] [PLOS ONE]
- [1.5] Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer [2019] [80001219] [Nature medicine]
- [1.6] Microbial mucosal colonic shifts associated with the development of colorectal cancer reveal the presence of different bacterial and archaeal biomarkers [2015] [80000707] [Journal of Gastroenterology]
- [1.7] Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer [2012] [80000305] [PLOS ONE]
- [1.8] Colorectal Cancer and the Human Gut Microbiome: Reproducibility with Whole-Genome Shotgun Sequencing [2016] [80000421] [PLOS ONE]
- [1.9] Human gut microbiome and risk for colorectal cancer [2013] [80000705] [Journal of the National Cancer Institute]
- [1.10] Microbiota disbiosis is associated with colorectal cancer. [2015] [80000302] [Frontiers in Microbiology]
- [1.11] Tumour-associated and non-tumour-associated microbiota in colorectal cancer. [2017] [80000455] [Gut]
- [1.12] Microbial dysbiosis in colorectal cancer (CRC) patients [2011] [80000252] [PLOS ONE]
- [1.13] Potential of fecal microbiota for early-stage detection of colorectal cancer [2014] [80000814] [Molecular Systems Biology]
- [1.14] Gut mucosal microbiome across stages of colorectal carcinogenesis [2015] [80000724] [Nature communications]
- [1.15] Alterations in enteric virome are associated with colorectal cancer and survival outcomes [2018] [80001264] [Gastroenterology]
- [1.16] Gut microbiota and host gene mutations in colorectal cancer patients and controls of Iranian and Finnish origin [2020] [80001320] [Anticancer Research]
- [1.17] Gut microbiome compositional and functional differences between tumor and non-tumor adjacent tissues from cohorts from the US and Spain [2015] [80000710] [Gut microbes]
- [1.18] Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer [2015] [80000593] [Gut]
- [1.19] Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families [2020] [80001258] [Gut microbes]
- [1.20] Dysbiosis signature of fecal microbiota in colorectal cancer patients. [2013] [80000296] [Microbial Ecology]
- [1.21] Characterization of mucosa-associated microbiota in matched cancer and non-neoplastic mucosa from patients with colorectal cancer [2019] [80001145] [Frontiers in Microbiology]
- [1.22] Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment [2015] [80000748] [Genome Medicine]
- [1.23] High occurence of Fusobacterium nucleatum and Clostridium difficile in the intestinal microbiota of colorectal carcinoma patients [2015] [80000299] [Brazilian Journal of Microbiology]
- [1.24] Altered intestinal microbiota associated with colorectal cancer [2019] [80001232] [Frontiers of Medicine]
- [1.25] Alterations of the predominant fecal microbiota and disruption of the gut mucosal barrier in patients with early-stage colorectal cancer [2020] [80001354] [BioMed Research International]
- [1.26] The human gut microbiome as a screening tool for colorectal cancer [2014] [80000706] [Cancer Prevention Research]
- [1.27] Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers [2012] [80000715] [The ISME Journal]
- [1.28] Real-time polymerase chain reaction quantification of specific butyrate-producing bacteria, Desulfovibrio and Enterococcus faecalis in the feces of patients with colorectal cancer. [2008] [80000301] [Journal of Gastroenterology and Hepatology]
- [1.29] Altered fecal small RNA profiles in colorectal cancer reflect gut microbiome composition in stool samples [2019] [80001048] [mSystems]
- [1.30] Re-purposing 16S rRNA gene sequence data from within case paired tumor biopsy and tumor-adjacent biopsy or fecal samples to identify microbial markers for colorectal cancer [2018] [80001019] [PLOS ONE]
- [1.31] Comparison of gut microbiome in human colorectal cancer in paired tumor and adjacent normal tissues [2020] [80001290] [OncoTargets and Therapy]
- [1.32] Microbiota-based model improves the sensitivity of fecal immunochemical test for detecting colonic lesions [2016] [80000747] [Genome Medicine]
- [1.33] Detection of Fusobacterium nucleatum in stool and colonic tissues from Norwegian colorectal cancer patients [2019] [80001408] [European Journal of Clinical Microbiology & Infectious Diseases]
- [1.34] Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer [2016] [80000430] [World journal of gastroenterology]
- [1.35] Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma [2012] [80001091] [Genome Research]
- [1.36] The oral microbiota in colorectal cancer is distinctive and predictive [2017] [80000657] [Gut]
- [1.37] Diversified pattern of the human colorectal cancer microbiome [2013] [80000295] [Gut Pathogens]
- [1.38] Metabolomics and 16S rRNA sequencing of human colorectal cancers and adjacent mucosa [2018] [80001025] [PLOS ONE]
- [1.39] Changes of the intestinal microbiota, short chain fatty acids, and fecal pH in patients with colorectal cancer [2013] [80000303] [Digestive Diseases and Sciences]
- [1.40] Microbiota Composition, HSP70 and Caspase-3 Expression as Marker for Colorectal Cancer Patients in Aceh, Indonesia [2016] [80000545] [Acta Medica Indonesiana - The Indonesian Journal of Internal Medicine]
- [1.41] Alterations in the abundance and co-occurence of Akkermansia muciniphila and Faecalibacterium prausnitzii in the colonic mucosa of inflammatory bowel disease subjects [2018] [80000842] [Frontiers in Cellular and Infection Microbiology]
- [1.42] Specialized metabolites from the microbiome in health and disease [2014] [Review] [80000036] [Cell Metabolism]
- [1.43] Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis [2017] [Research] [80000065] [Gut]
- [1.44] Microbiome in Colorectal Cancer: How to Get from Meta-omics to Mechanism? [2020] [Review] [80000200] [Trends in Microbiology]