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Sjögren syndrome {40000122}

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Definition:
Sjögren syndrome
Class:[  ]

Details


Other Terms:
SJS, SS, PSS
Initialisation date:
2020-09-06

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ICD:[  ]
Category:
Rheumatology
MedDra ID:[  ]
MedDra Level:[  ]

Notes


[  ]

Shared Notes


  • [1.6
    - The pSS patients had less beneficial or commensal butyrate-producing bacteria and a higher proportion of opportunistic pathogens with proinflammatory activity, which may impair intestinal barrier function and therefore contribute to inflammatory processes associated with pSS by increasing the production of proinflammatory cytokines and decreasing the release of the anti-inflammatory cytokine IL-10 and the peripheral FOXP3 mRNA expression, implicated in the development and function of regulatory T cells (Treg) cells.
    -pSS patients had gut dysbiosis associated with increased serum levels of proinflammatory cytokines including IL-6, IL-12, IL-17 and TNF-alpha (systemic inflammation) and zonulin (intestinal permeability) that resulted in increased systemic microbial exposure.
    -At the genera level, gut dysbiosis showed an increase in the abundance of the mucin-degrading and enteric pathogens Prevotella, Clostridium, Enterobacter, Escherichia, and Streptococcus and a depletion in the relative abundance of Bacteroides, Parabacteroides, Faecalibacterium, Roseburia, Ruminococcus, Dorea, Alistipes, Blautia and Bifidobacterium.
    - Prevotella contains enzymes that are important in mucin degradation, which may disrupt the colonic mucus barrier and increase intestinal permeability allowing the diffusion of pathogens, toxins, and antigens from the luminal environment into the mucosal tissues and circulatory system, resulting in the immune activation and tissue inflammation important in the onset or progression of several intestinal and chronic autoimmune diseases


[Coverage other Diseases (Overlap > 0.25)]

DiseaseOverlapCommon increased OrganismCommon decreased Organism
Sjögren syndrome 1.0000 41 (100%) : Actinomyces lingnae | Alloscardovia | Anaeroglobus | Atopobium | Atopobium parvulum | Bacteriodes uniformis | Bacteroides ovatus | Bacteroides thetaiotaomicron | Bacteroides vulgatus | Bifidobacterium | Blautia | Candida albicans | Clostridium | Delftia | Dialister | Enterobacter | Escherichia | Fusobacterium nucleatum | Lachnoanaerobaculum orale | Lactobacillus | Leucobacter | Megasphaera micronuciformis | Mitsuaria | Mitsuokella | Oribacterium asaccharolyticum | Parvimonas | Peptostreptococcaceae | Prevotella | Prevotella nanceiensis | Prevotella oralis | Pseudobutyrivibrio | Pseudochrobactrum | Ralstonia | Scardovia | Staphylococcus aureus | Streptococcus | Streptococcus mutans | Streptococcus parasanguinis | Streptococcus salivarius | Streptococcus vestibularis | Veillonella 46 (100%) : Abiotrophia | Actinomyces | Agathobacter | Alistipes | Alloprevotella | Bacteroidaceae | Bacteroides | Bergeyella | Bifidobacterium | Blautia | Butyrivibrio | Catonella morbi | Cellulosilyticum ruminicola | Clostridium | Comamonas | Dorea | Enterococcus | Faecalibacterium | Fretibacterium | Fusobacterium | Fusobacterium periodonticum | Granulicatella | Granulicatella adiacens | Haemophilus | Lautropia | Leptotrichia | Limnohabitans | Moryella | Neisseria | Neisseria flavescens | Parabacteroides | Peptococcus | Peptostreptococcaceae | Peptostreptococcus | Porphyromonas | Porphyromonas gingivalis | Porphyromonas pasteri | Prevotella | Prevotella nanceiensis | Prevotella pallens | Roseburia | Rothia | Ruminococcus | Stomatobaculum | Tanerella forsythia | Treponema
Crohn's disease 0.3568 15 (37%) : Bacteroides ovatus | Bacteroides vulgatus | Bifidobacterium | Blautia | Candida albicans | Clostridium | Escherichia | Fusobacterium nucleatum | Lactobacillus | Prevotella | Staphylococcus aureus | Streptococcus | Streptococcus mutans | Streptococcus salivarius | Veillonella 16 (35%) : Alistipes | Bacteroides | Bifidobacterium | Blautia | Clostridium | Dorea | Enterococcus | Faecalibacterium | Haemophilus | Moryella | Neisseria | Parabacteroides | Peptococcus | Prevotella | Roseburia | Ruminococcus
Obesity 0.3107 13 (32%) : Bacteroides vulgatus | Bifidobacterium | Blautia | Clostridium | Dialister | Escherichia | Fusobacterium nucleatum | Lactobacillus | Peptostreptococcaceae | Prevotella | Prevotella nanceiensis | Staphylococcus aureus | Streptococcus mutans 14 (30%) : Alistipes | Alloprevotella | Bacteroides | Bergeyella | Bifidobacterium | Blautia | Faecalibacterium | Fusobacterium | Leptotrichia | Parabacteroides | Prevotella | Roseburia | Rothia | Ruminococcus
Caries 0.3107 13 (32%) : Atopobium | Bacteroides thetaiotaomicron | Candida albicans | Lactobacillus | Mitsuokella | Peptostreptococcaceae | Prevotella | Prevotella oralis | Streptococcus | Streptococcus mutans | Streptococcus salivarius | Streptococcus vestibularis | Veillonella 14 (30%) : Actinomyces | Alloprevotella | Bergeyella | Fretibacterium | Fusobacterium | Fusobacterium periodonticum | Haemophilus | Leptotrichia | Neisseria | Peptococcus | Porphyromonas | Porphyromonas pasteri | Prevotella | Stomatobaculum
Autism 0.2919 7 (17%) : Bacteroides vulgatus | Bifidobacterium | Clostridium | Lactobacillus | Mitsuokella | Peptostreptococcaceae | Streptococcus 19 (41%) : Actinomyces | Alistipes | Alloprevotella | Bacteroides | Bifidobacterium | Blautia | Butyrivibrio | Enterococcus | Fusobacterium | Parabacteroides | Peptococcus | Peptostreptococcaceae | Peptostreptococcus | Porphyromonas | Prevotella | Roseburia | Rothia | Stomatobaculum | Treponema
Cirrhosis 0.2903 14 (34%) : Atopobium | Bacteroides vulgatus | Clostridium | Dialister | Enterobacter | Lactobacillus | Peptostreptococcaceae | Prevotella | Ralstonia | Streptococcus | Streptococcus parasanguinis | Streptococcus salivarius | Streptococcus vestibularis | Veillonella 11 (24%) : Actinomyces | Bacteroidaceae | Bacteroides | Bifidobacterium | Blautia | Dorea | Haemophilus | Leptotrichia | Neisseria | Prevotella | Ruminococcus
Ulcerative Colitis 0.2890 13 (32%) : Bacteroides vulgatus | Bifidobacterium | Blautia | Clostridium | Fusobacterium nucleatum | Lactobacillus | Mitsuokella | Parvimonas | Peptostreptococcaceae | Prevotella | Staphylococcus aureus | Streptococcus | Veillonella 12 (26%) : Alistipes | Bacteroidaceae | Bacteroides | Bifidobacterium | Blautia | Enterococcus | Haemophilus | Leptotrichia | Neisseria | Peptococcus | Prevotella | Roseburia
Colorectal cancer 0.2837 9 (22%) : Atopobium | Atopobium parvulum | Bifidobacterium | Escherichia | Fusobacterium nucleatum | Lactobacillus | Parvimonas | Prevotella | Streptococcus 16 (35%) : Actinomyces | Alistipes | Alloprevotella | Bacteroides | Bifidobacterium | Blautia | Dorea | Faecalibacterium | Fusobacterium periodonticum | Haemophilus | Leptotrichia | Neisseria | Parabacteroides | Prevotella | Roseburia | Ruminococcus
Cystic fibrosis 0.2784 5 (12%) : Blautia | Ralstonia | Staphylococcus aureus | Streptococcus | Veillonella 20 (43%) : Actinomyces | Alistipes | Alloprevotella | Bacteroides | Bergeyella | Bifidobacterium | Blautia | Butyrivibrio | Faecalibacterium | Fusobacterium | Granulicatella | Lautropia | Leptotrichia | Neisseria | Peptococcus | Porphyromonas | Prevotella | Roseburia | Rothia | Treponema
Smoking 0.2741 10 (24%) : Atopobium | Atopobium parvulum | Bifidobacterium | Fusobacterium nucleatum | Lactobacillus | Prevotella | Streptococcus | Streptococcus parasanguinis | Streptococcus salivarius | Veillonella 14 (30%) : Abiotrophia | Actinomyces | Fusobacterium periodonticum | Granulicatella | Granulicatella adiacens | Haemophilus | Leptotrichia | Neisseria | Neisseria flavescens | Peptococcus | Peptostreptococcus | Porphyromonas | Porphyromonas pasteri | Prevotella
HIV infection 0.2715 8 (20%) : Candida albicans | Enterobacter | Escherichia | Lactobacillus | Prevotella | Ralstonia | Streptococcus | Veillonella 16 (35%) : Alistipes | Bacteroides | Bifidobacterium | Blautia | Butyrivibrio | Clostridium | Dorea | Faecalibacterium | Fusobacterium | Haemophilus | Neisseria | Parabacteroides | Peptostreptococcaceae | Prevotella | Roseburia | Ruminococcus
Parkinson's Disease 0.2633 10 (24%) : Bifidobacterium | Blautia | Candida albicans | Dialister | Lactobacillus | Prevotella | Ralstonia | Streptococcus | Streptococcus mutans | Veillonella 13 (28%) : Actinomyces | Blautia | Clostridium | Dorea | Faecalibacterium | Granulicatella | Haemophilus | Leptotrichia | Neisseria | Prevotella | Roseburia | Rothia | Ruminococcus

Common References