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Microbiome & Chronic Diseases

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Disease ⇒ Liver fibrosis {40000302}

Record Keys


Type:
Disease
Definition:
Liver fibrosis
Parent:[  ]

Details


Initialisation date:[  ]
Other Terms:[  ]

Meta Information


MedDra ID:
10019668
MedDra Level:
pt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


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References Notes


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Shared Reference Notes


  • [1.4
    - Intestinal HDL is not routed to the systemic circulation. Rather, in the form of HDL3, it is directly transported to the liver through the hepatic portal vein. - There, it sequesters bacterial #Lipopolysaccharide from the gut that can trigger inflammation and liver damage. - In various models of liver injury, loss of enteric HDL exacerbated pathology. - By contrast, drugs elevating intestinal HDL improved disease outcomes.
  • [1.3] [#Indole-3-propionic acid (IPA)
    - Circulating IPA levels were found to be lower in individuals with liver fibrosis compared to those without fibrosis