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Disease ⇒ Behcet’s Disease {40000121}

Record Keys


Type:
Disease
Definition:
Behcet’s Disease
Parent:[  ]

Details


Initialisation date:
2020-09-06
Other Terms:
BD, Behçet Disease

Links


Meta Information


MedDra ID:
10004213
MedDra Level:
pt
ICD:[  ]
Category:
Rheumatology, Immunology
Zone:[  ]
Mechanism:
Gut Inflammation, Leaky gut, Reduced SCFA

Notes:


- A significant decrease of butyrate production in patients was demonstrated (1)
- Lack of butyrate (antiinflamatory) > Lack of Mucin

References Notes


[  ]

Shared Reference Notes


  • [1.8] [#Butyrate
  • [1.5] [#Butyrate, #Lactate
    - These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, #Sulfate-reducing bacteria, and some opportunistic pathogens but lacked #Butyric acid-producing bacteria and methanogenic bacteria. - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation. - enrichment of #Bilophila, Alistipes, and #Paraprevotella was observed in the BD-recipient group.
  • - a similar effect was observed by the administration of #Eubacterium rectale (a kind of #Butyrate-producing bacteria) in BD mice, which can upregulate NK1.1+ cells and reduce serum IL-17 levels and disease severity scores, sharing the partial mechanism of colchicine, which is used to treat BD patients.