Disease ⇒ Behcet’s Disease {40000121}

Record Keys
Type:	Disease
Definition:	Behcet’s Disease
Parent:	[ ]

Details
Initialisation date:	2020-09-06
Other Terms:	BD, Behçet Disease

Links
Wickipedia Merck Manual

Meta Information
MedDra ID:	10004213
MedDra Level:	pt
ICD:	[ ]
Category:	Rheumatology, Immunology
Zone:	[ ]
Mechanism:	Gut Inflammation, Leaky gut, Reduced SCFA

Notes:

- A significant decrease of butyrate production in patients was demonstrated (1)
- Lack of butyrate (antiinflamatory) > Lack of Mucin

References Notes

[ ]

Shared Reference Notes

[1.8] [#Butyrate]
[1.5] [#Butyrate, #Lactate]
- These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, #Sulfate-reducing bacteria, and some opportunistic pathogens but lacked #Butyric acid-producing bacteria and methanogenic bacteria. - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation. - enrichment of #Bilophila, Alistipes, and #Paraprevotella was observed in the BD-recipient group.
- a similar effect was observed by the administration of #Eubacterium rectale (a kind of #Butyrate-producing bacteria) in BD mice, which can upregulate NK1.1+ cells and reduce serum IL-17 levels and disease severity scores, sharing the partial mechanism of colchicine, which is used to treat BD patients.

↥ Microbiota

‐ Acidaminococcus ‎Stool ‎Human [1.1]
‐ Bacteroides eggerthii ‎Stool ‎Human [1.2]
‐ Bifidobacterium bifidum ‎Stool ‎Human [1.1]
‐ Bifidobacterium dentium ‎Saliva ‎Human [1.3]
‐ Bifidobacterium ‎Stool ‎Human [1.4]
‐ Bilophila ‎Stool ‎Human [1.2, 1.5]
‐ Collinsella aerofaciens ‎Stool ‎Human [1.2]
‐ Eggerthella lenta ‎Stool ‎Human [1.1]
‐ Eggerthella ‎Stool ‎Human [1.4]
‐ Eubacterium rectale ‎Ameliorative ‎Gut Lumen ‎Human [1.5]
‐ Fusobacterium ‎Stool ‎Human [1.2]
‐ Haemophilus parainfluenzae ‎Saliva ‎Human [1.6]
‐ Lactobacillus iners ‎Stool ‎Human [1.1]
‐ Lactobacillus mucosae ‎Stool ‎Human [1.1]
‐ Lactobacillus salivarius ‎Stool ‎Human [1.1]
‐ Mitsuokella multacida ‎Stool ‎Human [1.2]
‐ Oscillibacter ‎Stool ‎Human [1.2]
‐ Parabacteroides ‎Stool ‎Human [1.2]
‐ Paraprevotella clara ‎Stool ‎Human [1.2]
‐ Paraprevotella ‎Stool ‎Human [1.2, 1.5]
‐ Prevotella histicola ‎Saliva ‎Human [1.3]
‐ Rothia ‎Tissue biopsie ‎Human [1.3]
‐ Streptococcus ‎Stool ‎Human [1.1]

↧ Microbiota

‐ Acidiphilium ‎Stool ‎Human [1.2]
‐ Actinomyces graevenitzii ‎Saliva ‎Human [1.6]
‐ Alistipes ‎Stool ‎Human [1.2]
‐ Alloprevotella ‎Saliva ‎Human [1.6]
‐ Anaerotruncus ‎Stool ‎Human [1.2]
‐ Atopobium parvulum ‎Saliva ‎Human [1.6]
‐ Bacteroidetes ‎Saliva ‎Human [1.6]
‐ Bulleidia moorei ‎Saliva ‎Human [1.6]
‐ Butyrivibrio ‎Stool ‎Human [1.1]
‐ Campylobacter concisus ‎Saliva ‎Human [1.3]
‐ Campylobacter ‎Saliva ‎Human [1.6]
‐ Clostridiales ‎Saliva ‎Human [1.6]
‐ Clostridium ‎Stool ‎Human [1.2]
‐ Coprococcus ‎Stool ‎Human [1.2]
‐ Dialister invisus ‎Stool ‎Human [1.2]
‐ Eubacterium ‎Stool ‎Human [1.2]
‐ Filifactor ‎Stool ‎Human [1.1]
‐ Fusobacterium mortiferum ‎Stool ‎Human [1.2]
‐ Fusobacterium periodonticum ‎Saliva ‎Human [1.3]
‐ Gemella sanguinis ‎Saliva ‎Human [1.3]
‐ Lachnoanaerobaculum orale ‎Saliva ‎Human [1.6]
‐ Lachnospiraceae ‎Saliva ‎Human [1.6]
‐ Leptotrichia ‎Saliva ‎Human [1.6]
‐ Megamonas hypermegale ‎Stool ‎Human [1.1]
‐ Megamonas ‎Stool ‎Human [1.4]
‐ Megasphaera elsdenii ‎Stool ‎Human [1.2]
‐ Methanoculleus ‎Stool ‎Human [1.2]
‐ Methanomethylophilus ‎Stool ‎Human [1.2]
‐ Neisseria ‎Saliva ‎Human [1.3]
‐ Neisseria ‎Tissue biopsie ‎Human [1.3]
‐ Oribacterium sinus ‎Saliva ‎Human [1.3]
‐ Prevotella copri ‎Causal? ‎Gut Lumen ‎Human
‐ Prevotella enoeca ‎Saliva ‎Human [1.6]
‐ Prevotella pallens ‎Saliva ‎Human [1.6]
‐ Prevotella ‎Stool ‎Human [1.4]
‐ Pyramidobacter piscolens ‎Stool ‎Human [1.2]
‐ Roseburia ‎Causal? ‎Gut Lumen ‎Human
‐ Roseburia ‎Stool ‎Human [1.7]
‐ Selenomonas ‎Saliva ‎Human [1.6]
‐ Streptococcus infantis ‎Stool ‎Human [1.1]
‐ Subdoligranulum ‎Causal? ‎Gut Lumen ‎Human
‐ Subdoligranulum ‎Stool ‎Human [1.7]
‐ TM7 ‎Saliva ‎Human [1.6]
‐ Veillonella ‎Saliva ‎Human [1.6]
‐ Veillonella ‎Tissue biopsie ‎Human [1.3]

↥ Metabolome

‐ Butyrate ‎Ameliorative [1.5, 1.8]
‐ Lactate ‎Stool ‎Human [1.5]

↧ Metabolome

‐ Butyric acid ‎Causal? ‎Stool ‎Human [1.5]
‐ Sulfate ‎Stool ‎Human [1.5]

Related Factor

[ ]

Subclass

[ ]

References

(1) [Link REMOVED] [2015] Behçet’s syndrome patients exhibit specific microbiome signature.

Common References

[1.1] Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients witch Behcet’s disease [2019] [Clinical Rheumatology] [Journal] [80001223]
[1.2] A metagenomic study of the gut microbiome in Behcet’s disease [2018] [Microbiome] [Journal] [80000793]
[1.3] The oral mucosal and salivary microbial community of Behcet’s syndrome and recurrent aphthous stomatitis [2015] [Journal of Oral Microbiology] [Journal] [80000423]
[1.4] Bifidobacteria abundance-featured gut microbiota compositional change in patients with Behcet’s Disease [2016] [PLOS ONE] [Journal] [80000346]
[1.5] Findings on the Relationship Between Intestinal Microbiome and Vasculitis [2022] [Frontiers in Cellular and Infection Microbiology] [Journal] [80002464]
[1.6] Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behcet’s disease [2016] [Clinical Immunology] [Journal] [80000770]
[1.7] Behçet’s syndrome patients exhibit specific microbiome signature [2015] [Autoimmunity Reviews] [Journal] [80000507]
[1.8] Butyrate-Rich Diets Improve Redox Status and Fibrin Lysis in Behçet’s Syndrome [2021] [Research] [Circulation Research] [Journal] [80002329]

Disease ⇒ Behcet’s Disease {40000121}

Record Keys

Details

Links

Meta Information

Notes:

References Notes

Shared Reference Notes

Common References