Microbiome & Chronic Diseases

Evidence Based Medicine

Non alcoholic steatohepatitis {40000296}

Record Keys
Definition:	Non alcoholic steatohepatitis
Class:	[ ]

Details
Other Terms:	NASH
Authoring date:	[ ]

Meta Information
ICD:	[ ]
Category:	[ ]
MedDra ID:	10053219
MedDra Level:	pt

Notes

[ ]

Shared Notes

[1.8]
- Following administration of a high-fructose, high-fat diet, mice that received the human NAFL microbiota (NAFLR) gained more weight and had a higher liver triglycerides level and higher plasma LDL cholesterol than mice that received the human healthy microbiota (HR).

- Metabolomic analyses revealed that it was associated with lower and higher plasma levels of glycine and 3-Indolepropionic acid in NAFLR mice, respectively. Moreover, several bacterial genera and OTUs were identified as differently represented in the NAFLR and HR microbiota and therefore potentially responsible for the different phenotypes observed.

Common References

[1.1] Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH [2013] [80000566] [Hepatology]
[1.2] Gut microbiota dysbiosis in patients with biopsy-proven nonalcoholic fatty liver disease: a cross-sectional study in Taiwan [2020] [80001393] [Nutrients]
[1.3] Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach [2017] [80000626] [Hepatology]
[1.4] Intetinal microbiota in patients with nonalcoholic fatty liver disease [2013] [80000581] [Hepatology]
[1.5] Microbiome signatures associated with steatohepatitis and moderate to severe fibrosis in children with nonalcoholic fatty liver disease [2019] [80001063] [Gastroenterology]
[1.6] Bifidobacteria and lactobacilli in the gut microbiome of children with non-alcoholic fatty liver disease: which strains act as healthy players? [2018] [80000695] [Archives of Medical Science: AMS]
[1.7] Bile acids and dysbiosis in non-alcoholic fatty liver disease [2016] [80000595] [PLOS ONE]
[1.8] Fecal Microbiota Transplant from Human to Mice Gives Insights into the Role of the Gut Microbiota in Non-Alcoholic Fatty Liver Disease (NAFLD) [2021] [Research] [80001552] [Microorganisms]

Increased abundance of

‐ Alcaligenaceae Faeces ‎Human [1.1]
‐ Bacteroides coprocola Faeces ‎Human [1.2]
‐ Blautia Faeces ‎Human [1.3]
‐ Clostridium coccoides group Faeces ‎Human [1.4]
‐ Dorea Faeces ‎Human [1.3]
‐ Escherichia Faeces ‎Human [1.1]
‐ Lactobacillus Faeces ‎Human [1.5]
‐ Lactobacillus mucosae Faeces ‎Human [1.6]
‐ Lactobacillus ruminis Faeces ‎Human [1.6]
‐ Lactobacillus vaginalis Faeces ‎Human [1.6, 1.6]
‐ Megamonas Faeces ‎Human [1.2]
‐ Oribacterium Faeces ‎Human [1.5]
‐ Peptoniphilus Faeces ‎Human [1.1]
‐ Prevotella Faeces ‎Human [1.1]
‐ Ruminococcus Faeces ‎Human [1.3]

Decreased abundance of

‐ Alistipes Faeces ‎Human [1.1]
‐ Bacteroidetes Faeces ‎Human [1.4, 1.7]
‐ Bifidobacterium Faeces ‎Human [1.1]
‐ Bifidobacterium adolescentis Faeces ‎Human [1.6]
‐ Bifidobacterium bifidum Faeces ‎Human [1.6]
‐ Bifidobacterium longum Faeces ‎Human [1.6]
‐ Blautia Faeces ‎Human [1.1]
‐ Clostridium leptum Faeces ‎Human [1.7]
‐ Coprococcus Faeces ‎Human [1.1]
‐ Eubacterium Faeces ‎Human [1.1]
‐ Oscillospira Faeces ‎Human [1.1, 1.3]
‐ Roseburia Faeces ‎Human [1.1]
‐ Ruminococcaceae Faeces ‎Human [1.2]
‐ Ruminococcus Faeces ‎Human [1.1]

Related Metabolome

‐ 3-Indolepropionic acid ‎Increase ‎Mouse [1.8]
‐ Glycine ‎Decrease ‎Mouse [1.8]