Microbiome & Chronic Diseases

Evidence Based Medicine

Obesity (Diet induced) ⇒ Obesity {40000117}

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Obesity (Diet induced)


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Endocrinologic, DietNutrition
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- Lactobacillus plantarum suppresses the production of leptin.(4)

Shared Notes

  • [1.2
    - Long-term consumption of highly processed foods by pregnant women has been shown to alter gut microbial diversity and relative abundances in the newborn, and exposure of infants to such foods can influence appetite preferences and eating habits that persist throughout life
  • [1.3
    - Obesity alters the balance of Firmicutes in non-obese individuals to Bacteroidetes phyla in obese ones.
  • [1.4
    - Infants fed with breast milk rich in betaine showed reduced growth rates after birth.
    - Experiments in mice showed that giving betaine to female mice improved blood sugar metabolism and lowered fat tissue in breastfeeding offspring.
    - When breast-fed with milk rich in betaine, both mouse pups and human infants had higher amounts of Akkermansia bacteria in their guts.
    - Low levels of maternal betaine during pregnancy are linked to increased infant weight at birth.
    - Maternal betaine supplementation resulted in lower fetal weight in a mouse study.
  • [1.5
    - SPF mice that received a high-fat diet did gain weight. This diet quickly boosted the abundance of certain microbes in the small intestine, including microbes from the Clostridiaceae and Peptostreptococcaceae families. A member of Clostridiaceae was found to specifically impact fat absorption. The abundance of other bacterial families decreased on a high-fat diet including Bifidobacteriacaea and Bacteriodacaea, which are commonly associated with leanness.
  • [1.6
    - Lactobacillus casei can improve insulin resistance which is the underlying cause of obesity-associated metabolic abnormalities, in diet-induced obesity (DIO) mice.
  • [1.7
    - These changes in Akkermansia muciniphila were robustly correlated with the expression of lipid metabolism and inflammation markers in adipose tissue, as well as several circulating parameters (i.e., glucose, insulin, triglycerides, leptin) from DIO mice.

Common References